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Supports and methods for promoting integration of cartilage tissue explants

  • US 10,167,447 B2
  • Filed: 06/09/2014
  • Issued: 01/01/2019
  • Est. Priority Date: 12/21/2012
  • Status: Active Grant
First Claim
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1. A method of making a cartilage tissue construct, the method comprising:

  • placing a first surface of a first cartilage tissue piece and a first surface of a second cartilage tissue piece adjacent to an exposed surface of a solid or semi-solid support, wherein at least one of the first cartilage tissue piece and the second cartilage tissue piece comprises a cartilage explant;

    culturing, in vitro, the first cartilage tissue piece and the second cartilage tissue piece on the exposed surface of the support, including reorienting at least one of the first cartilage tissue piece and the second cartilage tissue piece, relative to the support, to direct the expansion or shape of the reoriented cartilage tissue piece.

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