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Method of sequencing nucleic acid colonies formed on a patterned surface by re-seeding

  • US 10,167,506 B2
  • Filed: 10/02/2017
  • Issued: 01/01/2019
  • Est. Priority Date: 12/23/2008
  • Status: Active Grant
First Claim
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1. A method of sequencing nucleic acids, the method comprising:

  • (a) contacting a substrate having spatially distinguishable features with a plurality of nucleic acids to seed a subset of the features, thereby generating a seeded subset;

    (b) amplifying the nucleic acids in the seeded subset to form nucleic acid colonies;

    (c) repeating steps (a) and (b) to increase the number of seeded features, thereby generating an array of nucleic acid colonies; and

    (d) sequencing the array of nucleic acid colonies.

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