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LQG artificial pancreas control system and related method

  • US 10,173,006 B2
  • Filed: 06/20/2008
  • Issued: 01/08/2019
  • Est. Priority Date: 06/21/2007
  • Status: Active Grant
First Claim
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1. A computer-implemented method for treating a patient with insulin, the patient suffering from diabetes mellitus (DM), by determining an insulin dosing recommendation to achieve an optimal glycemic control, the method comprising:

  • applying, by a processor, an adaptive observer scheme to estimate a present physiological state of a patient based on at least one measurement of blood glucose concentration in the patient, wherein the adaptive observer scheme models the present physiological state of the patient using a dynamic model that employs at least one physiological parameter;

    applying, by a processor, the estimated physiological state to a Linear Quadratic regulator to determine an insulin dosing recommendation based on the present physiological state so estimated, andoutputting, by a processor, the insulin dosing recommendation to a user to determine an appropriate insulin injection to be administered to said patient; and

    modifying, in the dynamic model, at least one physiological parameter based on an additional measurement of blood glucose concentration and blood insulin concentration from the patient to ensure absence of a bias between an estimated plasma glucose concentration and an actual plasma glucose concentration at steady state.

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