Methods, medical devices and kits for modifying the luminal profile of a body vessel

• US 10,173,027 B2
• Filed: 10/07/2016
• Issued: 01/08/2019
• Est. Priority Date: 10/07/2015
• Status: Active Grant

• Current Assignee: Cook Medical Technologies, LLC (Cook Group Incorporated)
• Original Assignee: Cook Medical Technologies, LLC (Cook Group Incorporated)
• Inventors: Sigmon, Jr., John C., Surti, Vihar
• Primary Examiner(s): Stewart, Jason-Dennis
• Application Number:
  US15/288,201
• Publication Number:
  US 20170100559A1
• Time in Patent Office: 823 Days
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61M 2025/0018 having a plug, e.g. an inflatable plug for closing catheter lumens
• CPC Class Codes: A61M 2025/0089 Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/0069 Tip not integral with tube
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61M 31/005 for contrast media

Abstract

Methods of modifying the luminal profile of a body vessel are described. An example method comprises advancing a cannula out of the distal end of a catheter disposed within the lumen of a body vessel of an animal and toward a target site on the wall of the body vessel; passing contrast dye through the cannula toward the target site; simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of the body vessel at the target site; and passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site. Medical devices, medical device assemblies, and kits are also described.

Claims

1. A method of modifying the luminal profile of a body vessel of an animal, comprising:

advancing a cannula out of the distal end of a catheter disposed within the lumen of said body vessel and toward a target site on the wall of said body vessel;

passing contrast dye through the cannula toward the target site;

simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of said body vessel at the target site; and

passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site

further comprising passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site;

wherein the passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site is performed before the step of passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

2. A method of modifying the luminal profile of a body vessel of an animal, comprising:

advancing a cannula out of the distal end of a catheter disposed within the lumen of said body vessel and toward a target site on the wall of said body vessel;

passing contrast dye through the cannula toward the target site;

simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of said body vessel at the target site; and

passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site

further comprising passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site;

wherein the passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site is performed simultaneously with the step of passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

3. A method of modifying the luminal profile of a body vessel of an animal, comprising:

advancing a cannula out of the distal end of a catheter disposed within the lumen of said body vessel and toward a target site on the wall of said body vessel;

passing contrast dye through the cannula toward the target site;

simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of said body vessel at the target site; and

passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site

further comprising passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site;

further comprising passing a buffer through the cannula between the bulking agent and the crosslinking agent.

4. A method of modifying the luminal profile of a body vessel of an animal, comprising:

locating a position of a natural valve within said body vessel;

advancing a cannula out of the distal end of a catheter disposed within the lumen of said body vessel and toward a target site on the wall of said body vessel and adjacent the natural valve;

passing contrast dye through the cannula toward the target site;

simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of said body vessel at the target site; and

passing bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site;

further comprising passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site;

wherein the passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site is performed before the step of passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

5. A method of modifying the luminal profile of a body vessel of an animal, comprising:

locating a position of a natural valve within said body vessel;

advancing a cannula out of the distal end of a catheter disposed within the lumen of said body vessel and toward a target site on the wall of said body vessel and adjacent the natural valve;

passing contrast dye through the cannula toward the target site;

simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of said body vessel at the target site; and

passing bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site;

further comprising passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site;

wherein the passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site is performed simultaneously with the step of passing a bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site.

6. A method of modifying the luminal profile of a body vessel of an animal, comprising:

locating a position of a natural valve within said body vessel;

advancing a cannula out of the distal end of a catheter disposed within the lumen of said body vessel and toward a target site on the wall of said body vessel and adjacent the natural valve;

passing contrast dye through the cannula toward the target site;

simultaneously continuing the advancing and passing until the distal end of the cannula punctures the inner layer of the wall of said body vessel at the target site; and

passing bulking agent through the cannula and into a space between connective tissue layers surrounding the vessel wall at the target site;

further comprising passing a crosslinking agent through the cannula and into the space between connective tissue layers surrounding the vessel wall at the target site;

further comprising passing a buffer through the cannula between the bulking agent and the crosslinking agent.