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Highly galactosylated anti-TNF-α antibodies and uses thereof

  • US 10,174,110 B2
  • Filed: 02/13/2014
  • Issued: 01/08/2019
  • Est. Priority Date: 02/13/2013
  • Status: Expired due to Fees
First Claim
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1. A composition, comprising:

  • a population of antibodies,wherein the antibodies in the population of antibodies are anti-TNF-alpha antibodies produced in mammary gland epithelial cells of a transgenic non-human mammal;

    wherein the level of galactosylation of the antibodies in the population of antibodies comprises at least 5% mono-galactosylated N-glycans or at least 10% bi-galactosylated N-glycans;

    wherein the level of fucosylation of the antibodies in the population of antibodies is at least 30%; and

    wherein the antibodies in the population of antibodies comprise a heavy chain comprising SEQ ID NO;

    1 and a light chain comprising SEQ ID NO;

    2.

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