Detecting echinocytes in blood

• US 10,175,164 B2
• Filed: 08/02/2012
• Issued: 01/08/2019
• Est. Priority Date: 08/08/2011
• Status: Expired due to Fees

• Current Assignee: Sony Corporation (Sony Group Corp.)
• Original Assignee: Sony Corporation (Sony Group Corp.)
• Inventors: Matsui, Eriko, Hayakawa, Tomohiro, Dowaki, Suguru, Tatsuta, Hirokazu, Kunihiro, Takeshi
• Primary Examiner(s): Hobbs, Lisa J
• Application Number:
  US13/565,032
• Publication Number:
  US 20130040337A1
• Time in Patent Office: 2,350 Days
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 2021/3155 Measuring in two spectral ranges, e.g. UV and visible
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence
• CPC Class Codes: G01N 21/33 using ultraviolet light G01N21/39 takes precedence

Abstract

As a result of acquiring visible absorption spectra of red blood cells and analyses of the spectra, inventors of the present disclosure have discovered the fact that echinocytes show a characteristic spectrum pattern having an absorption peak in a wavelength region of 450 to 490 nm between Soret and Q bands. Then, the present disclosure provides a blood analysis apparatus having an analysis section for detecting the absorption peak of a visible absorption spectrum acquired for blood. In accordance with this blood analysis apparatus, on the basis of the absorption peak, it is possible to detect echinocytes contained in blood.

Claims

1. A blood analysis apparatus, comprising:

a light source configured to radiate visible light to a sample of blood;

at least one lens to converge light reflected by the blood;

a spectroscope configured to acquire a visible absorption spectrum based on the converged light;

circuitry configured to

detect a peak between a Soret absorption band and a Q absorption band in the visible absorption spectrum, wherein the peak is detected at a protruding edge of echinocytes in the blood,

identify presence of the echinocytes in the blood based on the detection of the peak between the Soret absorption band and the Q absorption band in the visible absorption spectrum;

determine that the peak indicates a heme structure distortion caused by change in a location of globin present in the blood, wherein the heme structure distortion further indicates the presence of the echinocytes; and

control a display device to display a result of the detection of the peak and the presence of the echinocytes.

2. The blood analysis apparatus according to claim 1, wherein the circuitry is further configured to detect the peak that appears in a wavelength region of about 472 nm to identify the presence of the echinocytes.

3. The blood analysis apparatus according to claim 1, wherein the circuitry is further configured to control the display device to display that the peak is detected.

4. The blood analysis apparatus according to claim 1, wherein the circuitry is further configured to control the display device to display that the echinocytes exist in the blood.

5. The blood analysis apparatus according to claim 1, wherein the circuitry is further configured to control print of the result of the detection of the peak and the presence of the echinocytes.

6. The blood analysis apparatus according to claim 1, wherein the circuitry is further configured to store a standard spectrum to compare the standard spectrum and the visible absorption spectrum to identify difference in spectrum shape.

7. The blood analysis apparatus according to claim 1, wherein the circuitry is further configured to identify normal blood cells, that change into the echinocytes after a time period, based on the detection of the peak between the Soret absorption band and the Q absorption band in the visible absorption spectrum.