Method for quantifying brain injuries
First Claim
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1. An ex-vivo method of detecting and/or quantifying brain injuries of a test subject comprising:
- a) measuring the fractional anisotropy FA1 in at least one first region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject,b) measuring the axial diffusivity DA1 in at least one second region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject,c) measuring the radial diffusivity DR1 in at least one third region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject,d) determining the ratios SFA, SDA, and SDR as defined below by comparison of the measured values FA1, DA1, DR1 to normal regional values from a reference group of healthy subjects of fractional anisotropy FAn, of axial diffusivity DAn and of radial diffusivity RDn, for said regions according to the following formulae;
SFA=(FA1/FAn)
SDA=(DA1/DAn)
SRD=(DR1/DRn)d′
) determining that said region of the brain of said test subject is injured if the value of SFA, SDA, and/or SDR is greater than or less than 1 plus or minus two times the standard deviation of the regional measurements from the reference group of healthy subjects respectively of the reference fractional anisotropy, axial diffusivity, radial diffusivity in said region of interest.
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Abstract
The invention relates to an ex vivo method for detecting and/or quantifying brain injuries. The invention also relates to an ex vivo method for monitoring the evolution of a brain injury, and to an ex vivo method for predicting when a patient will come out of a coma. The invention is particularly applicable in the field of medicine and in the field of clinical studies.
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Citations
10 Claims
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1. An ex-vivo method of detecting and/or quantifying brain injuries of a test subject comprising:
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a) measuring the fractional anisotropy FA1 in at least one first region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject, b) measuring the axial diffusivity DA1 in at least one second region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject, c) measuring the radial diffusivity DR1 in at least one third region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject, d) determining the ratios SFA, SDA, and SDR as defined below by comparison of the measured values FA1, DA1, DR1 to normal regional values from a reference group of healthy subjects of fractional anisotropy FAn, of axial diffusivity DAn and of radial diffusivity RDn, for said regions according to the following formulae;
SFA=(FA1/FAn)
SDA=(DA1/DAn)
SRD=(DR1/DRn)d′
) determining that said region of the brain of said test subject is injured if the value of SFA, SDA, and/or SDR is greater than or less than 1 plus or minus two times the standard deviation of the regional measurements from the reference group of healthy subjects respectively of the reference fractional anisotropy, axial diffusivity, radial diffusivity in said region of interest. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An ex-vivo method of monitoring the trend of a brain injury in a test subject comprising the following steps at a time t0 and at a time t1:
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a) measuring the fractional anisotropy FA1 at t0 and FA2 at t1 in at least one first region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of a test subject, b) measuring the axial diffusivity DA1 at t0 and DA2 at t1 in at least one second region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject, c) measuring the radial diffusivity DR1 at t0 and DR2 at t1 in at least one third region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject, d) determining the ratios SFA1, SDA1, SRD1, SFA2, SDA2, and SRD2 as defined below by comparison of the measured values FA1, DA1, DR1, FA2, DA2, DR2 against normal regional values of fractional anisotropy FAn, of axial diffusivity DAn and of radial diffusivity DRn, for said regions according to the following formulae;
SFA1=(FA1/FAn)
SDA1=(DA1/DAn)
SDR1=(DR1/DRn)
SFA2=(FA2/FAn)
SDA2=(DA2/DAn)
SDR2=(DR2/DRn)e) determination of the variation Δ
SFA, Δ
SDA, Δ
SDR according to the following formulae;
Δ
SFA=SFA2−
SFA1
Δ
SDA=SDA2−
SDA1
Δ
SDR=SDR2−
SDR1e′
) determining that an aggravation of the injury has occurred if there is a negative variation of at least one value Δ
SFA, Δ
SDA, e″
) determining that a recovery of the injury has occurred if there is a positive variation of at least one value Δ
SFA, Δ
SDA,e′
″
) determining that a recovery of the injury has occurred if there is a negative variation of Δ
SDR, ande″
″
) determining that an aggravation of the injury has occurred if there is a positive variation of Δ
SDR. - View Dependent Claims (10)
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Specification