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Method for quantifying brain injuries

  • US 10,176,578 B2
  • Filed: 10/15/2013
  • Issued: 01/08/2019
  • Est. Priority Date: 10/17/2012
  • Status: Active Grant
First Claim
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1. An ex-vivo method of detecting and/or quantifying brain injuries of a test subject comprising:

  • a) measuring the fractional anisotropy FA1 in at least one first region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject,b) measuring the axial diffusivity DA1 in at least one second region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject,c) measuring the radial diffusivity DR1 in at least one third region of the brain on an image obtained by magnetic resonance imaging (MRI) of the brain of said test subject,d) determining the ratios SFA, SDA, and SDR as defined below by comparison of the measured values FA1, DA1, DR1 to normal regional values from a reference group of healthy subjects of fractional anisotropy FAn, of axial diffusivity DAn and of radial diffusivity RDn, for said regions according to the following formulae;


    SFA=(FA1/FAn)
    SDA=(DA1/DAn)
    SRD=(DR1/DRn)d′

    ) determining that said region of the brain of said test subject is injured if the value of SFA, SDA, and/or SDR is greater than or less than 1 plus or minus two times the standard deviation of the regional measurements from the reference group of healthy subjects respectively of the reference fractional anisotropy, axial diffusivity, radial diffusivity in said region of interest.

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