Hydrogel compositions for tooth whitening

• US 10,179,096 B2
• Filed: 05/23/2017
• Issued: 01/15/2019
• Est. Priority Date: 05/01/2001
• Status: Expired due to Fees

• Current Assignee: A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences,, Corium LLC
• Original Assignee: Avtopchiev Institute of Petrochemical Synthesis Russian Academy of Sciences, Corium International, Inc.
• Inventors: Singh, Parminder, Cleary, Gary W., Mudumba, Sri, Feldstein, Mikhail M., Bayramov, Danir F.
• Primary Examiner(s): Maewall, Snigdha
• Application Number:
  US15/603,226
• Publication Number:
  US 20170252275A1
• Time in Patent Office: 602 Days
• CPC Class Codes: A61C 19/066 Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
• CPC Class Codes: A61K 2800/262 Transparent; Translucent
• CPC Class Codes: A61K 2800/54 Polymers characterized by specific structures/properties
• CPC Class Codes: A61K 2800/5422 nonionic
• CPC Class Codes: A61K 2800/5424 anionic
• CPC Class Codes: A61K 2800/59 Mixtures
• CPC Class Codes: A61K 6/20 Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
• CPC Class Codes: A61K 6/30 Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
• CPC Class Codes: A61K 6/65 Dyes
• CPC Class Codes: A61K 6/78 Pigments
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/8152 Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/817 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
• CPC Class Codes: A61K 8/8176 Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 11/02 : Preparations for deodorising, bleaching or disinfecting dentures
• CPC Class Codes: C08L 1/08 : Cellulose derivatives
• CPC Class Codes: C08L 2312/00 : Crosslinking
• CPC Class Codes: C08L 33/06 : of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
• CPC Class Codes: C08L 39/04 : Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
• CPC Class Codes: C08L 53/00 : Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 71/02 : Polyalkylene oxides

Abstract

A composition is provided, wherein the composition comprises a water-swellable, water insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied to the teeth in need of whitening, and then removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Claims

1. A tooth whitening system, comprising:

an outer substrate that serves as an external surface of the system following application to a tooth surface;

a tooth contact adhesive layer adhered to the outer substrate, and

a removable release liner positioned on the tooth contact adhesive layer;

wherein the tooth contact adhesive layer comprises a composition comprising;

(a) a water-swellable, water-insoluble copolymer of methacrylic acid and ethyl acrylate;

(b) a blend of polyvinyl pyrrolidone and polyethylene glycol; and

(c) a peroxide whitening agent.

2. The tooth whitening system of claim 1, wherein the copolymer has a ratio of free carboxyl groups to ester groups in a range of about 1:

1 to 1;

2.

3. The tooth whitening system of claim 1, wherein the polyvinyl pyrrolidone has a number average molecular weight in the range of approximately 100,000 to 2,000,000.

4. The tooth whitening system of claim 1, wherein the polyvinyl pyrrolidone has a number average molecular weight in the range of approximately 500,000 to 1,500,000.

5. The tooth whitening system of claim 1, wherein the polyethylene glycol has a molecular weight in the range of about 45 to 800.

6. The tooth whitening system of claim 1, wherein the polyethylene glycol has a molecular weight in the range of about 45 to 600.

7. The tooth whitening system of claim 1, wherein the peroxide is hydrogen peroxide or carbamide peroxide.

8. The tooth whitening system of claim 1, comprising from about 1-20 weight percent of the water-swellable, water insoluble copolymer;

from about 20-80 weight percent of polyvinyl pyrrolidone;

from about 10-50 weight percent of polyethylene glycol; and

from about 0.1 to 60 weight percent of the peroxide whitening agent.

9. The tooth whitening system of claim 8, comprising from about 1 to 20 weight percent of the peroxide whitening agent.

10. The tooth whitening system of claim 1, comprising from about 6-12 weight percent of the water-swellable, water insoluble copolymer;

from about 40-60 weight percent of polyvinyl pyrrolidone;

from about 15-35 weight percent of polyethylene glycol; and

from about 0.1 to 30 weight percent of the peroxide whitening agent.

11. The tooth whitening system of claim 10, comprising from about 1 to 20 weight percent of the peroxide whitening agent.

12. A method for whitening a tooth, comprising:

providing a tooth whitening system comprised of (i) an outer substrate that serves as an external surface of the system following application to a tooth surface;

(ii) a tooth contact adhesive layer adhered to the outer substrate, and (iii) a removable release liner positioned on the tooth contact adhesive layer;

wherein the tooth contact adhesive layer comprises a composition comprising;

(a) a water-swellable, water-insoluble copolymer of methacrylic acid and ethyl acrylate;

(b) a blend of polyvinyl pyrrolidone and polyethylene glycol; and

(c) a peroxide whitening agent.

13. The method of claim 12, further comprising:

removing the release liner and applying the tooth contact adhesive layer to a tooth using manual pressure to the outer substrate.

14. The method of claim 13, wherein after said applying, the tooth contact adhesive layer remains in contact with the tooth for a period of between about 10 minutes to 8 hours.

15. The method of claim 13, wherein after said applying, the tooth contact adhesive layer remains in contact with the tooth for a period of between about 30 minutes to 1 hour.

16. The method of claim 13, further comprising removing the tooth contact adhesive layer from the tooth.