Enhanced flexibility neurovascular catheter with tensile support

• US 10,179,224 B2
• Filed: 02/27/2017
• Issued: 01/15/2019
• Est. Priority Date: 02/24/2016
• Status: Active Grant

• Current Assignee: Imperative Care, Inc., Incept LLC
• Original Assignee: Incept LLC
• Inventors: Yang, Yi, Khosravi, Fred, Young, Lisa M.
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): STILES, AMBER R.
• Application Number:
  US15/443,838
• Publication Number:
  US 20170239440A1
• Time in Patent Office: 687 Days
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12168 having a mesh structure A61B17/1214 takes precedence
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/22012 in direct contact with, or very close to, the obstruction or concrement for removing obstructions in blood vessels by laser A61B18/245
• CPC Class Codes: A61B 17/2202 the ultrasound transducer being inside patient's body at the distal end of the catheter
• CPC Class Codes: A61B 17/22031 Gripping instruments, e.g. forceps, for removing or smashing calculi A61B17/221 takes precedence
• CPC Class Codes: A61B 17/3203 Fluid jet cutting instruments
• CPC Class Codes: A61B 17/32037 for removing obstructions from inner organs or blood vessels, e.g. for atherectomy
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 17/320758 with a rotating cutting instrument, e.g. motor driven A61B17/320725, A61B17/32075 and A61B17/320783 take precedence; for removing intra-ocular material A61F9/00763; endoscopic rotatable cutting instruments A61B17/32002
• CPC Class Codes: A61B 2017/00398 using powered actuators, e.g. stepper motors, solenoids
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00734 battery operated
• CPC Class Codes: A61B 2017/00862 elastic or resilient for sutures A61B2017/0618
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/00898 expandable upon contact with fluid
• CPC Class Codes: A61B 2017/00955 thermoplastic
• CPC Class Codes: A61B 2017/22025 applying a shock wave A61B2017/22091 takes precedence
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/22038 : with a guide wire
• CPC Class Codes: A61B 2017/22062 : to be filled with liquid
• CPC Class Codes: A61B 2017/22067 : Blocking; Occlusion A61B2017/22054 takes precedence
• CPC Class Codes: A61B 2017/22079 : with suction of debris
• CPC Class Codes: A61B 2017/22084 : stone- or thrombus-dissolving
• CPC Class Codes: A61B 2017/320733 : with a flexible cutting or scraping element, e.g. with a whip-like distal filament member
• CPC Class Codes: A61B 2017/320775 : Morcellators, impeller or propeller like means
• CPC Class Codes: A61B 2217/005 : with suction drainage system
• CPC Class Codes: A61B 6/481 : involving the use of contrast agents
• CPC Class Codes: A61B 6/501 : for diagnosis of the head, e.g. neuroimaging or craniography
• CPC Class Codes: A61F 2/95 : Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2007/126 : for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 : Devices for heating or cooling internal body cavities
• CPC Class Codes: A61L 2400/10 : Materials for lubricating medical devices
• CPC Class Codes: A61L 2400/16 : Materials with shape-memory or superelastic properties
• CPC Class Codes: A61L 29/02 : Inorganic materials
• CPC Class Codes: A61L 29/041 : obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/06 : obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/14 : Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61M 1/32 : Oxygenators without membranes
• CPC Class Codes: A61M 1/743 : by changing the cross-section of the line, e.g. flow regulating valves A61M1/7413 takes precedence
• CPC Class Codes: A61M 1/80 : Suction pumps A61M1/64, A61M1/71, A61M60/00 take precedence
• CPC Class Codes: A61M 1/84 : Drainage tubes; Aspiration tips for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32
• CPC Class Codes: A61M 2025/0002 : with a pressure sensor at the distal end
• CPC Class Codes: A61M 2025/0004 : having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/0046 : Coatings for improving slidability
• CPC Class Codes: A61M 2025/0058 : having an electroactive polymer material, e.g. for steering purposes, for control of flexibility, for locking, for opening or closing
• CPC Class Codes: A61M 2025/0059 : having means for preventing the catheter, sheath or lumens from collapsing due to outer forces, e.g. compressing forces, or caused by twisting or kinking
• CPC Class Codes: A61M 2025/0079 : Separate user-activated means, e.g. guidewires, guide tubes, balloon catheters or sheaths, for sealing off an orifice, e.g. a lumen or side holes, of a catheter
• CPC Class Codes: A61M 2025/0096 : being laterally outward extensions or tools, e.g. hooks or fibres
• CPC Class Codes: A61M 2025/0175 : having telescopic features, interengaging nestable members movable in relations to one another
• CPC Class Codes: A61M 2039/062 : used with a catheter
• CPC Class Codes: A61M 2205/0216 : Materials providing elastic properties, e.g. for facilitating deformation and avoid breaking
• CPC Class Codes: A61M 2205/0266 : Shape memory materials
• CPC Class Codes: A61M 2205/3344 : Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2210/12 : Blood circulatory system
• CPC Class Codes: A61M 25/0009 : Making of catheters or other medical or surgical tubes
• CPC Class Codes: A61M 25/0012 : with embedded structures, e.g. coils, braids, meshes, strands or radiopaque coils
• CPC Class Codes: A61M 25/0023 : by the form of the lumen, e.g. cross-section, variable diameter
• CPC Class Codes: A61M 25/0045 : multi-layered, e.g. coated coating materials A61L29/08
• CPC Class Codes: A61M 25/005 : with embedded materials for reinforcement, e.g. wires, coils, braids
• CPC Class Codes: A61M 25/0052 : Localized reinforcement, e.g. where only a specific part of the catheter is reinforced, for rapid exchange guidewire port
• CPC Class Codes: A61M 25/0053 : having a variable stiffness along the longitudinal axis, e.g. by varying the pitch of the coil or braid
• CPC Class Codes: A61M 25/007 : Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/0074 : Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/008 : Strength or flexibility characteristics of the catheter tip
• CPC Class Codes: A61M 25/0082 : Catheter tip comprising a tool
• CPC Class Codes: A61M 25/0097 : characterised by the hub connectors A61M39/10
• CPC Class Codes: A61M 25/01 : Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence
• CPC Class Codes: A61M 25/0102 : Insertion or introduction using an inner stiffening member, e.g. stylet or push-rod
• CPC Class Codes: A61M 25/0108 : using radio-opaque or ultrasound markers
• CPC Class Codes: A61M 25/0147 : with movable mechanical means, e.g. pull wires
• CPC Class Codes: A61M 25/0662 : Guide tubes
• CPC Class Codes: A61M 25/09 : Guide wires
• CPC Class Codes: A61M 25/10 : Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1027 : Making of balloon catheters
• CPC Class Codes: A61M 31/005 : for contrast media
• CPC Class Codes: A61M 39/06 : Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof
• CPC Class Codes: A61M 5/007 : for contrast media
• CPC Class Codes: B29C 41/02 : for making articles of definite length, i.e. discrete articles
• CPC Class Codes: B29C 41/14 : Dipping a core B29C41/10 takes precedence
• CPC Class Codes: B29C 41/22 : Making multilayered or multicoloured articles
• CPC Class Codes: B29C 41/42 : Removing articles from moulds, cores or other substrates B29C33/444 and B29C37/0017 take precedence
• CPC Class Codes: B29C 63/18 : using tubular layers or sheathings B29C63/26 and B29C63/38 take precedence; placing tubular labels around rigid containers B65C3/065
• CPC Class Codes: B29C 63/20 : using pressure difference, e.g. vacuum
• CPC Class Codes: B29C 63/22 : using layers or sheathings having a shape adapted to the shape of the article B29C63/26 and B29C63/38 take precedence
• CPC Class Codes: B29C 66/52 : Joining tubular articles, bars or profiled elements
• CPC Class Codes: B29C 66/522 : Joining tubular articles B29C66/53241 takes precedence
• CPC Class Codes: B29C 66/5221 : for forming coaxial connections, i.e. the tubular articles to be joined forming a zero angle relative to each other
• CPC Class Codes: B29K 2027/18 : PTFE, i.e. polytetrafluorethene , e.g. ePTFE, i.e. expanded polytetrafluorethene
• CPC Class Codes: B29K 2075/00 : Use of PU, i.e. polyureas or polyurethanes or derivatives thereof, as moulding material
• CPC Class Codes: B29L 2031/7542 : Catheters

Abstract

An enhanced flexibility neurovascular catheter is provided, such as for distal neurovascular access or aspiration. The catheter includes an elongate flexible body, having a proximal end, a distal end and a side wall defining a central lumen. A distal zone of the side wall includes an outer jacket surrounding a helical coil, and the outer jacket is formed from a plurality of tubular segments positioned coaxially about the coil. A proximal one of the tubular segments has a durometer of at least about 60D, and a distal one of the tubular segments has a durometer of no more than about 35D. An axially extending filament within the side wall extends at least about the most distal 10 cm of the length of the catheter. The axially extending filament serves as a tension support and resists elongation of the catheter wall under tension, such as when the catheter is being proximally retracted through tortuous vasculature.

Claims

1. An enhanced flexibility neurovascular catheter, comprising:

an elongate flexible body, having a proximal end, a distal end and a side wall defining a central lumen, a distal zone of the side wall comprising a helical coil,

wherein the elongated flexible body comprises an outer jacket formed from a plurality of tubular segments and extending coaxially about the coil, wherein a proximal one of the tubular segments has a durometer of at least about 60D and a distal one of the tubular segments has a durometer of no more than about 35D; and

wherein the elongated flexible body comprises an axially extending filament within the side wall, extending at least about the most distal 10 cm of the length of the catheter and less than about 40 cm from the distal end of the catheter, the filament configured to resist elongation of the catheter wall under tension,

wherein the axially extending filament extends proximally past a proximal end of the helical coil.

2. An enhanced flexibility neurovascular catheter as in claim 1, wherein the filament extends at least about the most distal 15 cm of the length of the catheter.

3. An enhanced flexibility neurovascular catheter as in claim 2, wherein the filament comprises multiple fibers.

4. An enhanced flexibility neurovascular catheter as in claim 2, further comprising an inner liner, wherein the filament extends axially in between the coil and the inner liner.

5. An enhanced flexibility neurovascular catheter as in claim 2, wherein the side wall further comprises:

a tubular inner liner;

a tie layer separated from the lumen by the inner liner;

wherein the helical coil surrounds the tie layer, and adjacent windings of the coil are spaced progressively further apart in the distal direction.

6. An enhanced flexibility neurovascular catheter as in claim 5, wherein the tubular inner liner is formed by dip coating a removable mandrel.

7. An enhanced flexibility neurovascular catheter as in claim 5, wherein the tubular inner liner comprises polytetrafluoroethylene.

8. An enhanced flexibility neurovascular catheter as in claim 5, wherein the tie layer comprises polyurethane.

9. An enhanced flexibility neurovascular catheter as in claim 8, wherein the tie layer has a wall thickness of no more than about 0.005 inches.

10. An enhanced flexibility neurovascular catheter as in claim 8, wherein the tie layer extends along at least the most distal 20 cm of the flexible body.

11. An enhanced flexibility neurovascular catheter as in claim 5, wherein the coil comprises a shape memory material.

12. An enhanced flexibility neurovascular catheter as in claim 11, wherein the coil comprises Nitinol.

13. An enhanced flexibility neurovascular catheter as in claim 12, wherein the Nitinol comprises an Austenite state at body temperature.

14. An enhanced flexibility neurovascular catheter as in claim 5, wherein the outer jacket is formed from at least five discrete tubular segments.

15. An enhanced flexibility neurovascular catheter as in claim 5, wherein the outer jacket is formed from at least nine discrete tubular segments.

16. An enhanced flexibility neurovascular catheter as in claim 15, wherein the difference in durometer between a proximal one of the tubular segments and a distal one of the tubular segments is at least about 20D.

17. An enhanced flexibility neurovascular catheter as in claim 15, wherein the difference in durometer between a proximal one of the tubular segments and a distal one of the tubular segments is at least about 30D.

18. An enhanced flexibility neurovascular catheter as in claim 1, wherein the filament extends at least about the most distal 20 cm of the length of the catheter.

19. An enhanced flexibility neurovascular catheter as in claim 1, wherein the catheter can withstand at least about 3.5 pounds tension before failure.

20. An enhanced flexibility neurovascular catheter as in claim 1, wherein the catheter can withstand at least about 5 pounds tension before failure.

21. An enhanced flexibility neurovascular catheter as in claim 1, wherein the catheter can withstand at least about 7 pounds tension before failure.