Swallowable drug delivery device and methods of drug delivery
First Claim
1. An ingestible device suitable for swallowing into a lumen of a gastrointestinal tract of a patient, the lumen having a lumen wall, the device comprising:
- a capsule sized to pass through the intestinal tract;
a preparation comprising a solid therapeutic agent comprising a protein or polypeptide disposed in the capsule, the preparation shaped as a tissue penetrating member and configured to be inserted into a wall of a small intestine, the preparation comprising at least one protein or polypeptide which would chemically degrade if released within the lumen of the gastrointestinal tract; and
a release element operably coupled to the therapeutic agent preparation, the release element configured to release the solid therapeutic agent from the capsule into the wall of the small intestine responsive to a condition in the small intestine, wherein when the preparation is released into the wall of the small intestine, chemical degradation of the protein or polypeptide in the lumen is inhibited.
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Accused Products
Abstract
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
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Citations
24 Claims
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1. An ingestible device suitable for swallowing into a lumen of a gastrointestinal tract of a patient, the lumen having a lumen wall, the device comprising:
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a capsule sized to pass through the intestinal tract; a preparation comprising a solid therapeutic agent comprising a protein or polypeptide disposed in the capsule, the preparation shaped as a tissue penetrating member and configured to be inserted into a wall of a small intestine, the preparation comprising at least one protein or polypeptide which would chemically degrade if released within the lumen of the gastrointestinal tract; and a release element operably coupled to the therapeutic agent preparation, the release element configured to release the solid therapeutic agent from the capsule into the wall of the small intestine responsive to a condition in the small intestine, wherein when the preparation is released into the wall of the small intestine, chemical degradation of the protein or polypeptide in the lumen is inhibited. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification