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Swallowable drug delivery device and methods of drug delivery

  • US 10,179,228 B2
  • Filed: 08/30/2016
  • Issued: 01/15/2019
  • Est. Priority Date: 12/24/2009
  • Status: Active Grant
First Claim
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1. An ingestible device suitable for swallowing into a lumen of a gastrointestinal tract of a patient, the lumen having a lumen wall, the device comprising:

  • a capsule sized to pass through the intestinal tract;

    a preparation comprising a solid therapeutic agent comprising a protein or polypeptide disposed in the capsule, the preparation shaped as a tissue penetrating member and configured to be inserted into a wall of a small intestine, the preparation comprising at least one protein or polypeptide which would chemically degrade if released within the lumen of the gastrointestinal tract; and

    a release element operably coupled to the therapeutic agent preparation, the release element configured to release the solid therapeutic agent from the capsule into the wall of the small intestine responsive to a condition in the small intestine, wherein when the preparation is released into the wall of the small intestine, chemical degradation of the protein or polypeptide in the lumen is inhibited.

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