Personalized pain management treatments

• US 10,179,239 B2
• Filed: 03/24/2016
• Issued: 01/15/2019
• Est. Priority Date: 01/15/2013
• Status: Active Grant

• Current Assignee: iTrace Biomedical Inc.
• Original Assignee: iTrace Biomedical Inc.
• Inventors: Sharma, Krishnamohan
• Primary Examiner(s): CHAO, ELMER M
• Application Number:
  US15/079,678
• Publication Number:
  US 20160243359A1
• Time in Patent Office: 1,027 Days
• CPC Class Codes: A61F 2007/0071 using a resistor, e.g. near the spot to be heated
• CPC Class Codes: A61F 2007/0075 using a Peltier element, e.g. near the spot to be heated or cooled
• CPC Class Codes: A61F 2007/0078 with a battery
• CPC Class Codes: A61F 2007/0093 programmed
• CPC Class Codes: A61F 2007/0095 with a temperature indicator
• CPC Class Codes: A61F 2007/029 Fat cell removal or destruction by non-ablative heat treatment
• CPC Class Codes: A61F 2007/108 Cold packs, i.e. devices to be cooled or frozen in refrigerator or freezing compartment
• CPC Class Codes: A61F 7/00 Heating or cooling appliances for medical or therapeutic treatment of the human body heating or cooling means in connection with bedsteads or mattresses A47C21/00 ; massage, therapeutic baths A61H; hyperthermia using electric or magnetic fields or ultrasound A61N; electric heating elements H05B
• CPC Class Codes: A61F 7/007 characterised by electric heating
• CPC Class Codes: A61F 7/08 Warming pads, pans or mats A61F7/02 takes precedence; Hot-water bottles
• CPC Class Codes: A61F 7/10 Cooling bags, e.g. ice-bags
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 2007/0008 Destruction of fat cells
• CPC Class Codes: A61N 2007/0013 Fracture healing
• CPC Class Codes: A61N 2007/0017 Wound healing
• CPC Class Codes: A61N 5/025 Warming the body, e.g. hyperthermia treatment
• CPC Class Codes: A61N 5/0625 Warming the body, e.g. hyperthermia treatment
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

Systems and methods disclosed herein provide efficacious pain management therapies based on delivery of physical medicine(s) via computer-implemented systems. Patient information comprising patient pain symptoms, patient physiological measurements, patient demographics, and other information is received at a pain therapy device. The patient information is compared with pain analytics data compiled on a plurality of individuals to determine a personalized pain management therapy. The personalized pain management therapy is applied via a combination of thermoceuticals, electroceuticals, ultrasound, and several other forms of physical medicine. Sensors coupled to the pain therapy device measure changes in physiological data resulting from the pain management therapy. The personalized pain management therapy can be adjusted based on the changes in the physiological data and/or patient feedback. The patient information, information about the applied therapy, and therapy outcome information is added to the analytics database.

Claims

1. A system, comprising:

a patient analytics database comprising, for each prior patient of a plurality of prior patients, a profile comprising demographic data and physiological measurements correlated with an applied pain management therapy and an outcome comprising either satisfactory or unsatisfactory; and

a pain therapy device communicatively coupled to the patient analytics database, the pain therapy device comprising;

an applicator comprising a thermoelectric element, an ultrasound transducer, and an electrode component;

a plurality of physiological sensors;

a processor; and

a memory communicatively coupled to the processor and comprising instructions configured to be executed by the processor, wherein the processor is configured to receive the instructions from the memory and to execute the instructions to perform operations comprising;

accessing, for a new patient, new patient demographic data and a new patient initial pain score;

receiving new patient physiological measurements from the plurality of physiological sensors;

receiving, from the patient analytics database, a pain management therapy for the new patient, the pain management therapy comprising (i) a thermoelectric parameter that controls a temperature of the thermoelectric element, (ii) an ultrasound parameter that controls ultrasound output by the ultrasound transducer, or (iii) an electrode parameter that controls electrical output by the electrode component, wherein the pain management therapy is determined by identifying a reference profile comprising an outcome identified as satisfactory and one of;

(i) demographic data matching the new patient demographic data or (ii) physiological data matching the new patient physiological measurements;

applying the pain management therapy to the new patient via the applicator by applying one or more of the thermoelectric parameter, the ultrasound parameter, or the electrode parameter to the applicator;

responsive to determining that the pain management therapy is complete, receiving, from the pain therapy device, an updated pain score for the new patient; and

storing, in the patient analytics database, a new patient profile comprising the demographic data for the new patient, the initial pain score, the updated pain score, and the new patient physiological measurements.

2. The system of claim 1, the operations further comprising:

determining an indication of reduced pain for the new patient by determining that the updated pain score is lower than the initial pain score by a threshold amount; and

updating the new profile in the patient analytics database with the indication and marking the new profile as a successful treatment.

3. The system of claim 1, wherein the physiological measurements comprise:

a vital sign of the patient, a local body temperature of the patient, a local tissue temperature of the patient, a local blood flow rate of the patient, a local blood oxygen level of the patient, a local body tissue thickness of the patient, or a local body tissue density of the patient.

4. The system of claim 1, wherein the pain therapy device further comprises a user input device, and wherein the initial pain score and the updated pain score are received via the input device.

5. The system of claim 1, wherein the pain therapy device further comprises:

a heat switch and a cold switch communicatively coupled to the processor and configured to control the thermoelectric element based on the thermoelectric parameter;

an ultrasound switch, an ultrasound intensity control, and an ultrasound duty cycle communicatively coupled to the processor;

an ultrasound power amplifier communicatively coupled to the ultrasound switch, the ultrasound intensity control, and the ultrasound duty cycle, the ultrasound power amplifier configured to drive the ultrasound transducer based on the ultrasound parameter; and

an electric stimulation switch communicatively coupled to the processor and an electric stimulation circuit communicatively coupled to the electric stimulation switch, the electric stimulation circuit configured to drive the electrode component based on the electrode parameter.

6. The system of claim 5, wherein the thermoelectric parameter is configured to set the heat switch and the cold switch.

7. The system of claim 5, wherein the ultrasound parameter is configured to set the ultrasound switch, the ultrasound intensity control, and the ultrasound duty cycle.

8. The system of claim 5, wherein the electrode parameter is configured to set the electric stimulation switch.

9. The system of claim 1, wherein the plurality of physiological sensors comprise a temperature sensor, a blood flow sensor, an oxygen sensor, and a tissue thickness sensor.

10. The system of claim 1, wherein the operations further comprise:

determining an indication that the pain therapy is not satisfactory by determining that the updated pain score is not less than the initial pain score by a threshold;

updating the new patient profile in the patient analytics database with the indication;

receiving, from the patient analytics database, an updated pain management therapy comprising (i) an updated thermoelectric parameter, (ii) an updated ultrasound parameter, or (iii) an updated electrode parameter, wherein the updated pain management therapy is determined by identifying, in the patient analytics database, an additional reference profile comprising an outcome identified as satisfactory and (i) demographic data matching the new patient demographic data or (ii) physiological data matching the new patient physiological measurements; and

titrating the pain management therapy by applying the (i) updated thermoelectric parameter, (ii) the updated ultrasound parameter, or (iii) the updated electrode parameter to the applicator.

11. The system of claim 10, wherein titrating the pain management therapy for the patient comprises adjusting a duration corresponding to at least one of the thermoelectric parameter, the ultrasound parameter, or the electrode parameter.

12. The system of claim 1, wherein demographic data comprises (i) an age range, (ii) a gender, (iii) a body mass index, or (iv) a pre-existing medical condition.

13. The system of claim 1, the operations further comprising receiving a new patient pain type comprising one of (i) acute pain, (ii) chronic pain, or (iii) musculoskeletal pain, wherein each profile of the plurality of profiles further comprises a pain type and wherein the reference profile comprises a pain type identical to the new patient pain type.

14. The system of claim 1, wherein identifying the reference profile is performed by a server device.