Tissue oxygenation monitoring in heart failure
First Claim
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1. A medical device comprising:
- a therapy delivery module configured to deliver a therapy based on a therapy delivery control parameter;
an optical sensor for sensing a signal of light attenuated by a localized volume of a blood-perfused body tissue;
a processor configured to;
compute a tissue oxygenation measurement of an availability of oxygen at the localized tissue volume from the optical sensor signal during the therapy being delivered based on the therapy delivery control parameter,detect a decrease in tissue oxygenation by comparing the tissue oxygenation measurement to a threshold; and
determine an adjusted therapy delivery control parameter in response to the decrease in tissue oxygenation tissue oxygenation.
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Abstract
A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.
124 Citations
31 Claims
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1. A medical device comprising:
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a therapy delivery module configured to deliver a therapy based on a therapy delivery control parameter; an optical sensor for sensing a signal of light attenuated by a localized volume of a blood-perfused body tissue; a processor configured to; compute a tissue oxygenation measurement of an availability of oxygen at the localized tissue volume from the optical sensor signal during the therapy being delivered based on the therapy delivery control parameter, detect a decrease in tissue oxygenation by comparing the tissue oxygenation measurement to a threshold; and determine an adjusted therapy delivery control parameter in response to the decrease in tissue oxygenation tissue oxygenation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method for monitoring delivery of a therapy in a medical device, comprising;
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delivering a therapy based on a therapy delivery control parameter; sensing an optical sensor signal of light attenuated by a localized volume of blood-perfused body tissue; computing a tissue oxygenation measurement of an availability of oxygen at the localized tissue volume from the optical sensor signal during the therapy being delivered based on the therapy delivery control parameter; detecting a decrease in tissue oxygenation by comparing the tissue oxygenation measurement to a threshold; and determining an adjusted therapy delivery control parameter in response to the decrease in tissue oxygenation tissue oxygenation. - View Dependent Claims (26, 27, 28, 29, 30)
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31. A non-transitory computer readable medium having computer executable instructions stored thereon that, when executed, cause a medical device:
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deliver a therapy based on a therapy delivery control parameter; sense an optical sensor signal of light attenuated by a localized volume of blood-perfused body tissue; compute a tissue oxygenation measurement of an availability of oxygen at the localized tissue volume from the optical sensor signal during the therapy being delivered based on the therapy delivery control parameter; detect a decrease in tissue oxygenation by comparing the tissue oxygenation measurement to a threshold; and determine an adjusted therapy delivery control parameter in response to the decrease in tissue oxygenation tissue oxygenation.
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Specification