×

Methods and compositions for increasing transgene activity

  • US 10,179,918 B2
  • Filed: 04/28/2016
  • Issued: 01/15/2019
  • Est. Priority Date: 05/07/2015
  • Status: Active Grant
First Claim
Patent Images

1. A method of increasing nuclease activity in a cell, the method comprising:

  • introducing an mRNA comprising a 3′

    untranslated region (3′

    UTR) and encoding at least one component of one or more nucleases into the cell, wherein the mRNA comprises a woodchuck hepatitis virus posttranslational regulatory element (WPRE) as shown in any of SEQ ID NOs;

    1-3 in the 3′

    UTR.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×