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Multigenome retroviral vector preparations and methods and systems for producing and using same

  • US 10,179,919 B2
  • Filed: 02/22/2017
  • Issued: 01/15/2019
  • Est. Priority Date: 02/23/2016
  • Status: Active Grant
First Claim
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1. A recombinant multigenome retroviral vector preparation comprising:

  • a. a first retroviral particle comprising two copies of a first retroviral vector genome comprising a first sequence of interest;

    b. a second retroviral particle comprising two copies of a second retroviral vector genome comprising a second sequence of interest;

    c. a third retroviral particle comprising one copy of the first retroviral vector genome comprising a first sequence of interest and one copy of the second retroviral vector genome comprising a second sequence of interest;

    d. a fourth retroviral particle comprising two copies of a third retroviral vector genome comprising a third sequence of interest;

    e. a fifth retroviral particle comprising one copy of the first retroviral vector genome comprising a first sequence of interest and one copy of the third retroviral vector genome comprising the third sequence of interest; and

    f. a sixth retroviral particle comprising one copy of the second retroviral vector genome comprising a second sequence of interest and one copy of the third retroviral vector genome comprising the third sequence of interest;

    wherein the first, second and third sequences of interest are different; and

    wherein the retroviral vector preparation is pseudotyped with a heterologous envelope glycoprotein.

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