Configuration and spatial placement of frontal electrode sensors to detect physiological signals

• US 10,182,736 B2
• Filed: 10/14/2013
• Issued: 01/22/2019
• Est. Priority Date: 10/12/2012
• Status: Active Grant

• Current Assignee: Salk Institute for Biological Studies
• Original Assignee: Salk Institute for Biological Studies, Regents of the University of California (University of California)
• Inventors: Coleman, Todd Prentice, Ma, Rui, Bajema, Michael, Gil Da Costa, Ricardo, Fung, Raynard
• Primary Examiner(s): Cohen, Lee S
• Application Number:
  US14/435,398
• Publication Number:
  US 20150313498A1
• Time in Patent Office: 1,926 Days
• CPC Class Codes: A61B 5/163 by tracking eye movement, gaze, or pupil change
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/167 Personality evaluation
• CPC Class Codes: A61B 5/168 Evaluating attention deficit, hyperactivity
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/296 for electromyography [EMG]
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/375 using biofeedback
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/378 Visual stimuli
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61B 5/381 Olfactory or gustatory stimuli
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/6803 Head-worn items, e.g. helmets, masks, headphones or goggles
• CPC Class Codes: A61B 5/6814 Head

Abstract

Methods, systems, and devices are disclosed for acquiring and analyzing physiological signals. In one aspect, a physiological sensor device includes a substrate formed of an electrically insulative material and structured to allow physical contact of the device with the frontal region of the head of a user, a recording electrode configured at a first location on the substrate to acquire an electrophysiological signal of the user, a reference electrode configured at a second location on the substrate to acquire a reference signal to the electrophysiological signal, and a ground electrode configured at a third location at least partially between the first and the second locations on the substrate, in which the first location is posterior to the second and third locations, and in which the device is operable when electrically coupled to an electrical circuit to detect physiological signals of the user.

Claims

1. An electroencephalography (EEG) system, comprising:

an EEG sensor device comprising a substrate formed of an electrically insulative material and structured to allow physical contact of the device with a forehead of a user;

a first electrode configured at a first location on the substrate to acquire an EEG signal of the user from the user'"'"'s forehead;

a second electrode configured at a second location on the substrate to acquire a second EEG signal of the user as a reference signal to the EEG signal; and

a third electrode configured on the substrate to acquire a third EEG signal of the user as an electrical ground signal,

wherein the third electrode is configured at a third location at least partially between the first and the second locations on the substrate, and the first location is configured above the second and third locations along a vertical direction in a frontal plane when the EEG sensor device is placed on the forehead of the user, and wherein the first electrode and the second electrode are spaced apart by at most 24 mm, and

wherein, when electrically coupled to an electrical circuit, the device is operable to detect physiological signals of the user,

wherein the device is implemented in the system to provide a cognitive or sensory assessment, wherein the system further comprises a data processing system in communication with the EEG sensor device and includes one or more memory units and one or more processors configured to process the detected physiological signals as physiological data to generate an information set including one or more quantitative values associated with a cognitive-sensory profile category indicative of one or more aspects of cognitive or sensory functions.

2. The system as in claim 1, wherein the first, second, and third electrodes are linearly arranged on the substrate.

3. The system as in claim 1, wherein the substrate is formed of a mechanically flexible material structured to adhere to skin or a wearable item of the user.

4. The system as in claim 3, further comprising:

electrical interface components formed separately on the substrate and electrically coupled to the first, second, and third electrodes, respectively, via electrically conductive conduits,

wherein, when the device is electrically coupled to the electrical circuit, the electrical interface components are electrically coupled to the electrical circuit via wires.

5. The system as in claim 3, further comprising:

the electrical circuit,

wherein the electrical circuit includes;

a signal processing circuit formed on the substrate in electrical communication with the first, second, and third electrodes via electrically conductive conduits, the signal processing circuit to amplify acquired EEG signals, and

a transmitter unit on the substrate in electrical communication with the signal processing circuit to transmit the amplified EEG signals to the data processing system.

6. The system as in claim 5, further comprising:

a power supply module electrically coupled to the electrical circuit to provide electrical power to the transmitter unit.

7. The system as in claim 5, wherein the EEG sensor device is configured as a wearable patch worn on the user'"'"'s scalp.

8. The system as in claim 5, wherein the EEG sensor device is configured in a region of a wearable item capable of physical contact with the user'"'"'s scalp.

9. The system as in claim 1, further comprising:

a fourth electrode configured at a fourth location on the substrate to acquire a fourth EEG signal of the user; and

a fifth electrode configured at a fifth location on the substrate to acquire a fifth EEG signal of the user,

wherein the fourth location is configured left of the first location, and the fifth location is configured right of the first location.

10. The system as in claim 1, wherein the one or more processors of the data processing system are configured to process the physiological signals detected by the EEG sensor device to generate the information set by:

selecting time intervals of interest within the physiological data based on the presented stimuli and the cognitive-sensory profile category,

grouping, into one or more grouped data sets, the physiological data corresponding to the selected time intervals of interest, and

providing a statistical measure of a relationship across or within the grouped data sets to generate the one or more quantitative values.

11. The system as in claim 1, wherein the one or more quantitative values includes a quantitative score depicting a level of one or both of cognitive and sensory performance based on at least one of the user'"'"'s attention, memory, learning ability, confabulation characteristics, pattern integration ability, semantic integration ability, target detection ability, emotional valence, preference, or awareness, and wherein the quantitative score depicts the level at a particular time.

12. The system as in claim 1, wherein the system further comprises:

a stimulus delivery device to produce a sequence of stimuli based on the cognitive-sensory profile category that is presented to the user wearing the EEG sensor device, wherein the stimuli includes at least one of a visual, auditory, olfactory, tactile, or gustatory stimulating medium,

wherein the EEG sensor device is interfaced to the user to detect the physiological signals exhibited by the user before, during, and after a presentation of the sequence of stimuli.

13. The system as in claim 1, wherein the data processing system includes:

a local computer proximate to and in communication with the EEG sensor device to receive the detected physiological signals from the EEG sensor device, the local computer configured to conduct initial processing of the detected physiological signals to produce initial physiological signal data, and

a remote computer in communication with the local computer via a communication network or link to receive the initial physiological signal data from the local computer and to process the initial physiological signal data to generate the information set including one or more quantitative values associated with the cognitive-sensory profile category.

14. The system as in claim 13, wherein the local computer is a mobile communications device including a smartphone or tablet that is in wireless communications with the EEG sensor device.

15. A wearable physiological sensor device, consisting of:

a substrate formed of a mechanically flexible and an electrically insulative material and structured to allow physical contact of the device with a forehead of a user;

three electrodes on the substrate arranged along a vertical direction in a frontal plane when the physiological sensor device is placed on the forehead of the user, including;

a first electrode configured at a first location on the substrate to acquire an electrophysiological signal of the user,

a second electrode configured at a second location below the first location on the substrate to acquire a second electrophysiological signal of the user as a reference signal to the electrophysiological signal,

a third electrode configured at a third location at least partially between the first and the second locations on the substrate to acquire a third electrophysiological signal of the user as an electrical ground signal, wherein the first electrode and the second electrode are spaced apart by at most 24 mm;

an electrical circuit on the substrate in electrical communication with the first, second, and third electrodes via electrically conductive conduits, the electrical circuit including an amplification circuit and a signal processing circuit to amplify and signal process the electrophysiological signals;

a transmitter unit on the substrate in electrical communication with the electrical circuit to transmit the amplified and signal processed electrophysiological signals to at least one of a data processing unit or a remote computer system; and

a power supply module electrically coupled to the transmitter unit to provide electrical power to the transmitter unit.

16. The device as in claim 15, wherein the first, second, and third electrodes are linearly arranged on the substrate.

17. The device as in claim 15, wherein the mechanically flexible substrate is structured to adhere to skin or a wearable item of the user.

18. An electroencephalography (EEG) sensor device, comprising:

a substrate formed of an electrically insulative material and structured to allow physical contact of the device with a forehead of a user;

a first electrode configured at a first location on the substrate to acquire an EEG signal of the user from the user'"'"'s forehead;

a second electrode configured at a second location on the substrate to acquire a second EEG signal of the user as a reference signal to the EEG signal;

a third electrode configured on the substrate to acquire a third EEG signal of the user as an electrical ground signal,

wherein the third electrode is configured at a third location at least partially between the first and the second locations on the substrate, and the first location is configured above the second and third locations along a vertical direction in a frontal plane when the EEG sensor device is placed on the forehead of the user, and wherein the first electrode and the second electrode are spaced apart by at most 24 mm; and

an electrical circuit including a signal processing circuit formed on the substrate in electrical communication with the first, second, and third electrodes via electrically conductive conduits, the signal processing circuit to amplify acquired EEG signals, and a transmitter unit on the substrate in electrical communication with the signal processing circuit to transmit the amplified EEG signals to at least one of a data processing unit or a remote computer system,

wherein the device is operable to detect physiological signals of the user.

19. The device as in claim 18, wherein the substrate is formed of a mechanically flexible material structured to adhere to skin or a wearable item of the user.

20. The device as in claim 18, further comprising:

a fourth electrode configured at a fourth location on the substrate to acquire a fourth EEG signal of the user; and

a fifth electrode configured at a fifth location on the substrate to acquire a fifth EEG signal of the user,

wherein the fourth location is configured left of the first location, and the fifth location is configured right of the first location.

21. A method to provide a cognitive or sensory assessment of a subject, comprising:

acquiring EEG signals of the subject from the frontal region of the subject'"'"'s head to produce physiological data using a system comprising a sensor device including;

a substrate formed of an electrically insulative material and structured to allow physical contact of the sensor device with the frontal region of the head of the subject, and

three electrodes including a recording electrode, a reference electrode, and a ground electrode to acquire the EEG signals of the subject from three respective positions arranged on the substrate along a vertical direction of the frontal region, wherein the recording electrode is configured above the ground and reference electrodes, and the ground electrode is configured between the recording and reference electrodes, and wherein the recording electrode and the reference electrode are spaced apart by at most 24 mm, and wherein the sensor device is implemented in the system to provide a cognitive or sensory assessment, wherein the system further comprise a data processing system in communication with the sensor device and includes one or more memory units and one or more processors configured to process the acquired EEG signals as physiological data; and

processing, by the system, the physiological data to generate an information set including one or more quantitative values associated with a cognitive-sensory profile category indicative of one or more aspects of cognitive or sensory functions.

22. The method as in claim 21, further comprising:

presenting a sequence of stimuli to the subject, the sequence of stimuli based on the cognitive-sensory profile category,

wherein the acquiring the EEG signals is implemented before, during, and after the presenting the sequence of stimuli.

23. The method as in claim 22, further comprising:

selecting the cognitive-sensory profile category from among a cognitive performance profile, a sensory performance profile, and a cognitive and sensory performance profile.

24. The method as in claim 22, wherein the sequence of stimuli includes at least one of a visual, auditory, olfactory, tactile, or gustatory stimulating medium based on the selected cognitive-sensory profile category.

25. The method as in claim 21, wherein the one or more quantitative values include a quantitative score depicting a level of one or both of cognitive and sensory performance based on at least one of the subject'"'"'s attention, memory, learning ability, confabulation characteristics, pattern integration ability, semantic integration ability, target detection ability, emotional valence, preference, or awareness state, and wherein the quantitative score depicts the level at a particular time.

26. The method as in claim 21, wherein the processing includes:

identifying a time interval associated with the EEG signals based on the cognitive-sensory profile category,

grouping the physiological data corresponding to the time interval into one or more grouped data sets, and

providing a statistical measure of a relationship across or within the grouped data sets to generate the one or more quantitative values for the selected cognitive-sensory profile category.