Transdermal drug delivery device
First Claim
1. A transdermal drug delivery device comprising:
- a housing in hiding an upper housing portion and a lower housing portion, the lower housing portion defining a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user, the upper housing portion at least partially surrounding a central region of the device;
a microneedle assembly disposed within the central region;
a reservoir disposed within the central region, the reservoir being in fluid communication with the microneedle assembly; and
a pushing element disposed above the microneedle assembly within the central region, the pushing element being configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means,wherein the microneedle assembly is configured to move independently of the lower housing portion.
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Accused Products
Abstract
A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.
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Citations
22 Claims
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1. A transdermal drug delivery device comprising:
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a housing in hiding an upper housing portion and a lower housing portion, the lower housing portion defining a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user, the upper housing portion at least partially surrounding a central region of the device; a microneedle assembly disposed within the central region; a reservoir disposed within the central region, the reservoir being in fluid communication with the microneedle assembly; and a pushing element disposed above the microneedle assembly within the central region, the pushing element being configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means, wherein the microneedle assembly is configured to move independently of the lower housing portion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A transdermal drug delivers;
- device comprising;
an upper housing attached to a lower housing defining a cavity, the lower housing defining a bottom surface including skin attachment means for releasably attaching the lower housing to skin of a user; the lower housing defining an opening and surrounding a microneedle assembly, the device configured such that the lower housing is dissociated from the microneedle assembly;
a reservoir disposed within the cavity and being in fluid communication with the microneedle assembly; anda pushing element disposed within the cavity between the microneedle assembly and the upper housing, the pushing element being configured to provide (i) a continuous force having a downward component, dissociated from the upper and lower housings, transmitted via the microneedle assembly towards the skin of a user, (ii) a continuous force having an upward component, dissociated from the microneedle assembly, transmitted to the lower housing. - View Dependent Claims (14, 15, 16, 17)
- device comprising;
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18. A method for transdermally delivering a drug formulation, the method comprising:
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positioning a transdermal drug delivery device adjacent to skin, wherein the transdermal drug delivery device comprises; a housing including an upper housing portion and a lower housing portion, the lower housing portion defining a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user, the upper housing portion at least partially surrounding a central region of the device; a microneedle assembly disposed within the central region, the microneedle assembly being configured to move independently of the lower housing portion; a reservoir disposed above the microneedle assembly within the central region, the reservoir being in fluid communication with the microneedle assembly; and a pushing element disposed above the microneedle assembly within the central region; and attaching the housing to the skin via the skin attachment means; applying, with the pushing element, a continuous bilateral force through the transdermal drug delivery device having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means; and delivering the drug formulation from through the microneedle assembly and into or through the skin. - View Dependent Claims (19)
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20. A transdermal drug delivery device comprising:
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a housing including an upper housing portion and a lower housing portion, the lower housing portion defining a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user, the upper housing portion at least partially surrounding a central region of the device; a microneedle assembly disposed within the central region; a reservoir disposed within the central region, the reservoir being in fluid communication with the microneedle assembly; and a pushing element disposed above the microneedle assembly within the central region, the pushing element being configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means, wherein the reservoir is disposed between the microneedle assembly and the pushing element, the downward component of the continuous bilateral force being transmitted through the reservoir to the microneedle assembly without increasing the pressure of a drug formulation contained within the reservoir. - View Dependent Claims (21)
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22. A transdermal drug delivery device comprising:
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a housing including an upper housing portion and a lower housing portion, the lower housing portion defining a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user, the upper housing portion at least partially surrounding a central region of the device; a microneedle assembly disposed within the central region; a reservoir disposed within the central region, the reservoir being in fluid communication with the microneedle assembly; and a pushing element disposed above the microneedle assembly within the central region, the pushing element being configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means, the pushing element comprising an expandable member positioned between the upper housing portion and the reservoir, the expandable member comprising an expandable material vacuum sealed within a jacket.
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Specification