Flexible biological fluid filters

• US 10,183,475 B2
• Filed: 06/13/2017
• Issued: 01/22/2019
• Est. Priority Date: 03/24/2014
• Status: Active Grant

• Current Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Inventors: Verri, Paolo, Lynn, Daniel, Day, Scott
• Primary Examiner(s): Gonzalez, Madeline
• Application Number:
  US15/621,191
• Publication Number:
  US 20170282531A1
• Time in Patent Office: 588 Days
• Field of Search: 210450, 210645, 210782, 210 94, 210499, 210335, 210488-490
• CPC Class Codes: A61M 1/3636 having a flexible housing
• CPC Class Codes: A61M 2202/0439 White blood cells; Leucocytes lymphocytes A61M2202/0407
• CPC Class Codes: B32B 2307/412 Transparent
• CPC Class Codes: B32B 2307/546 Flexural strength; Flexion stiffness
• CPC Class Codes: B32B 2307/726 Permeability to liquids, absorption
• CPC Class Codes: B32B 2327/06 PVC, i.e. polyvinylchloride
• CPC Class Codes: B32B 2535/00 Medical equipment, e.g. bandage, prostheses, catheter medical patches B32B2556/00
• CPC Class Codes: B32B 37/144 using layers with different mechanical or chemical conditions or properties, e.g. layers with different thermal shrinkage, layers under tension during bonding constructional features for tensioning B32B38/1825
• CPC Class Codes: B32B 37/18 involving the assembly of discrete sheets or panels only
• CPC Class Codes: Y10T 156/10 Methods of surface bonding and/or assembly therefor

Abstract

Filter assemblies are processing biological fluid, such as blood or a blood component containing leukocytes. The filter assemblies include a flexible housing with first and second walls. A filtration medium and a support member are at least partially positioned between the walls of the housing, with a seal joining the walls of the housing, the filtration medium, and the support member. The filter assemblies may further include a pre-filter and/or a post-filter positioned between the walls of the housing. If provided, the pre- and post-filter may be positioned on opposite walls of the filtration medium, with the post-filter being a mesh positioned between the filtration medium and one of the walls of the housing or within an opening defined by the support member. A seal of the filter assembly may pass through the filtration medium, with the filtration medium being substantially omitted in a section of the seal.

Claims

1. A biological fluid filter assembly comprising:

a flexible housing having first and second walls;

a filtration medium at least partially positioned between the first and second walls of the housing; and

a seal joining the first and second walls of the housing, the seal passing through the filtration medium to define a perimeter within the biological fluid filter assembly, with substantially no filtration medium present in a central section of the seal along at least a majority of the extent of the perimeter defined by the seal.

2. The biological fluid filter assembly of claim 1, wherein

the first and second walls are generally transparent,

the filtration medium is generally opaque, and

the central section of the seal is generally transparent along at least a majority of the extent of the perimeter defined by the seal.

3. The biological fluid filter assembly of claim 2, wherein the filtration medium is present in generally opaque peripheral sections of the seal.

4. The biological fluid filter assembly of claim 1, further comprising a pre-filter at least partially positioned between the filtration medium and the first wall of the housing, wherein the seal joins the first and second walls of the housing and the pre-filter.

5. The biological fluid filter assembly of claim 1, further comprising a support member at least partially positioned between the filtration medium and the second wall of the housing, wherein the seal joins the first and second walls of the housing and the support member.

6. The biological fluid filter assembly of claim 1, further comprising a mesh at least partially positioned between the filtration medium and the second wall of the housing.

7. The biological fluid filter assembly of claim 6, wherein

the mesh is part of a mesh element in which the mesh is integrally formed with a frame that surrounds the mesh to define a perimeter of the mesh element, and

the seal joins the first and second walls of the housing and the frame.

8. The biological fluid filter assembly of claim 4, further comprising a frame, wherein

the seal joins the first and second walls of the housing, the pre-filter, and the frame,

the first and second walls of the housing and the frame are formed of a polyvinyl chloride material,

the pre-filter is formed of a polyethylene terephthalate material, and

the filtration medium is formed of a polybutylene terephthalate material.

9. The biological fluid filter assembly of claim 4, further comprising a frame, wherein

the seal joins the first and second walls of the housing, the pre-filter, and the frame, and

the seal includes a pair of peripheral sections positioned at opposite sides of the central section and each comprising

a layer consisting only of the first wall,

an intermingled layer in which the first wall is intermingled with the pre-filter,

an intermingled interface in which molten filtration medium is intermingled with the pre-filter,

a layer consisting only of molten filtration medium,

a second intermingled interface in which molten filtration medium is intermingled with the frame,

a second intermingled layer in which the second wall and the frame are intermingled, and

a layer consisting only of the second wall.

10. The biological fluid filter assembly of claim 9, wherein the intermingled interface and the second intermingled interface each have a thickness of less than 150micrometers.

11. The biological fluid filter assembly of claim 9, wherein the filtration medium transitions from a molten state at an end of each peripheral section adjacent to the central section of the seal to a non-molten state at an opposite end of each peripheral section.

12. The biological fluid filter assembly of claim 1, further comprising an outer seal spaced outwardly of the seal and joining the first and second walls of the housing.

13. The biological fluid filter assembly of claim 12, wherein the outer seal joins only the first and second walls of the housing.

14. The biological fluid filter assembly of claim 12, further comprising a frame at least partially positioned between the filtration medium and the second wall of the housing, wherein the outer seal joins the first and second walls of the housing and the frame.

15. The biological fluid filter assembly of claim 12, further comprising an unsealed area between the seal and the outer seal.

16. The biological fluid filter assembly of claim 12, wherein the seal has a light transmissivity at least 8% of a light transmissivity of the outer seal.

17. The biological fluid filter assembly of claim 12, wherein the seal has a light transmissivity approximately 8-40% of a light transmissivity of the outer seal.

18. The biological fluid filter assembly of claim 12, further comprising a third seal positioned outwardly of the outer seal, wherein the third seal is perforated or scored or otherwise weakened to define a tear strip or tear seal.

19. The biological fluid filter assembly of claim 1, wherein the seal is generally symmetrical.

20. The biological fluid filter assembly of claim 1, wherein the seal is non-symmetrical.