Optimized Fc variants and methods for their generation
First Claim
Patent Images
1. A nucleic acid encoding a polypeptide comprising an Fc variant of a human IgG Fc polypeptide, said Fc variant comprising an amino acid substitution at position 328 in the Fc region, wherein numbering is according to the EU index.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
-
Citations
19 Claims
- 1. A nucleic acid encoding a polypeptide comprising an Fc variant of a human IgG Fc polypeptide, said Fc variant comprising an amino acid substitution at position 328 in the Fc region, wherein numbering is according to the EU index.
- 10. A nucleic acid encoding a heavy chain of an antibody comprising an Fc variant of a human IgG Fc polypeptide, said Fc variant comprising an amino acid substitution at position 328 in the Fc region, wherein numbering is according to the EU index.
Specification