Device for manipulating charged particles

• US 10,186,407 B2
• Filed: 09/14/2017
• Issued: 01/22/2019
• Est. Priority Date: 05/05/2011
• Status: Active Grant

• Current Assignee: Shimadzu Research Laboratory (Europe) Ltd. (Shimadzu Corporation)
• Original Assignee: Shimadzu Research Laboratory (Europe) Ltd. (Shimadzu Corporation)
• Inventors: Berdnikov, Alexander, Andreyeva, Alina, Giles, Roger
• Primary Examiner(s): McCormack, Jason
• Application Number:
  US15/704,366
• Publication Number:
  US 20180005811A1
• Time in Patent Office: 495 Days
• Field of Search: 250281, 250282, 250283, 250256, 250288, 250290
• CPC Class Codes: H01J 49/0095 Particular arrangements for generating, introducing or analyzing both positive and negative analyte ions ion/ion reactions H01J49/0072
• CPC Class Codes: H01J 49/06 Electron- or ion-optical arrangements
• CPC Class Codes: H01J 49/062 Ion guides linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421
• CPC Class Codes: H01J 49/065 having stacked electrodes, e.g. ring stack, plate stack

Abstract

The present invention is concerned with a device for charged particle transportation and manipulation. Embodiments provide a capability of combining positively and negatively charged particles in a single transported packet. Embodiments contain an aggregate of electrodes arranged to form a channel for transportation of charged particles, as well as a source of power supply that provides supply voltage to be applied to the electrodes, the voltage to ensure creation, inside the said channel, of a non-uniform high-frequency electric field, the pseudopotential of which field has one or more local extrema along the length of the channel used for charged particle transportation, at least, within a certain interval of time, whereas, at least one of the said extrema of the pseudopotential is transposed with time, at least within a certain interval of time, at least within a part of the length of the channel used for charged particle transportation.

Claims

1. A device for manipulating charged particles, the device comprising:

a series of electrodes arranged so as to form a channel for transportation of the charged particles;

a power supply unit adapted to provide supply voltages to said electrodes so as to create a non-uniform high-frequency electric field within said channel, the pseudopotential of said field having two or more local maxima along the length of said channel for transportation of charged particles, at least within a certain interval of time, wherein transportation of the charged particles along the length of the channel is provided by transposition of the at least two of said maxima of the pseudopotential such that the at least two of said maxima are caused to travel with time along the channel, at least within a certain interval of time and at least within a part of the length of the channel, wherein the supply voltages are high-frequency voltages;

wherein a first region of said channel forms part of an inlet intermediate device that is configured to inject ions into a collision cell containing buffer gas with sufficiently high kinetic energy to cause fragmentation of ions in the collision cell through collisions with the buffer gas;

wherein a second region of said channel forms part of the collision cell;

wherein a third region of said channel forms part of an outlet intermediate device configured to receive ions transported out from the collision cell.

2. A device according to claim 1, wherein the device is configured to propagate discrete bunches of parent ions into the collision cell such that daughter ions resulting from fragmentation of each bunch of parent ions substantially remain within the same bunch of propagating ions as the parent ions from which they derived due to confinement by the non-uniform high-frequency electric field.

3. A device according to claim 1, wherein the second region of the channel is maintained at a higher pressure than the first and third regions of the channel.

4. A device according to claim 1, wherein first, second and third regions are located within a single vacuum chamber with at least one pump for pumping away gas.

5. A device according to claim 1, wherein the collision cell has a gas inlet and at least two segments designated as conductance limiting segments, wherein each conductance limiting segment is configured to establish a pressure differential within the device.

6. A device according to claim 5, wherein each of the at least two segments is formed from four electrodes and four insulators where the four insulators form part of a supporting structure.

7. A device according to claim 1, wherein said channel has a variable profile along the length of the channel such that its cross section varies along its length.

8. A device according to claim 7, wherein the area of the cross section of the channel varies along the length of the channel.

9. A device according to claim 1, wherein some or all of the electrodes have a multipole profile.

10. A device according to claim 9, wherein the multipole profile is a coarsened multipole profile formed by any one or combination of:

plane, stepped, piecewise-stepped, linear, piecewise-linear, circular, rounded, piecewise-rounded, curvilinear, or piecewise-curvilinear profiles.

11. A device according to claim 1, wherein some or all of the electrodes are formed from metallic films deposited on a non-conductive substrates.

12. A device according to claim 1, wherein the channel is:

a rectilinear channel,

a curvilinear channel, or

is closed to form a ring-shaped channel.

13. A device according to claim 1, wherein the channel comprises a plurality of channels, wherein the plurality of channels are configured to operate in parallel.

14. A device according to claim 13, wherein each channel of the plurality of channels is configured to transport ions with a defined mass range.

15. A device according to claim 1, wherein the buffer gas comprises nitrogen.

16. A device according to claim 1, wherein said channel is enclosed within a tube.