System configured for measuring physiological parameters

• US 10,188,299 B2
• Filed: 05/12/2017
• Issued: 01/29/2019
• Est. Priority Date: 12/31/2012
• Status: Expired due to Fees

• Current Assignee: Omni Medsci, Inc.
• Original Assignee: Omni Medsci, Inc.
• Inventors: Islam, Mohammed N.
• Primary Examiner(s): Rahman, Md M
• Application Number:
  US15/594,053
• Publication Number:
  US 20170248567A1
• Time in Patent Office: 627 Days
• Field of Search: 356300
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 2562/146 for optical coupling
• CPC Class Codes: A61B 2576/02 specially adapted for a particular organ or body part
• CPC Class Codes: A61B 5/0013 Medical image data A61B1/00011, A61B6/56, A61B8/56 take precedence
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/0088 for oral or dental tissue
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/4547 Evaluating teeth
• CPC Class Codes: A61B 5/6801 specially adapted to be attached to or worn on the body surface
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 5/7405 using sound
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: G01J 2003/104 Monochromatic plural sources
• CPC Class Codes: G01J 2003/1208 Prism and grating
• CPC Class Codes: G01J 2003/2826 Multispectral imaging, e.g. filter imaging
• CPC Class Codes: G01J 3/0218 : using optical fibers
• CPC Class Codes: G01J 3/108 : for measurement in the infrared range
• CPC Class Codes: G01J 3/14 : using refracting elements, e.g. prisms G01J3/18, G01J3/26 take precedence prisms per se G02B5/04
• CPC Class Codes: G01J 3/1838 : Holographic gratings
• CPC Class Codes: G01J 3/28 : Investigating the spectrum using colour filters G01J3/51
• CPC Class Codes: G01J 3/2823 : Imaging spectrometer
• CPC Class Codes: G01J 3/42 : Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry beam switching arrangements G01J3/08
• CPC Class Codes: G01J 3/453 : by correlation of the amplitudes
• CPC Class Codes: G01M 3/38 : by using light G01M3/02 takes precedence
• CPC Class Codes: G01N 2021/3595 : using FTIR
• CPC Class Codes: G01N 2021/399 : Diode laser
• CPC Class Codes: G01N 21/35 : using infrared light G01N21/39 takes precedence
• CPC Class Codes: G01N 21/3563 : for analysing solids; Preparation of samples therefor
• CPC Class Codes: G01N 21/359 : using near infrared light
• CPC Class Codes: G01N 21/39 : using tunable lasers
• CPC Class Codes: G01N 21/85 : Investigating moving fluids or granular solids
• CPC Class Codes: G01N 21/88 : Investigating the presence of flaws or contamination
• CPC Class Codes: G01N 21/9508 : Capsules; Tablets
• CPC Class Codes: G01N 2201/0221 : Portable; cableless; compact; hand-held
• CPC Class Codes: G01N 2201/061 : Sources
• CPC Class Codes: G01N 2201/06113 : Coherent sources; lasers
• CPC Class Codes: G01N 2201/062 : LED's
• CPC Class Codes: G01N 2201/08 : Optical fibres; light guides
• CPC Class Codes: G01N 2201/12 : Circuits of general importance; Signal processing
• CPC Class Codes: G01N 2201/129 : Using chemometrical methods
• CPC Class Codes: G01N 33/02 : Food
• CPC Class Codes: G01N 33/025 : Fruits or vegetables
• CPC Class Codes: G01N 33/15 : Medicinal preparations ; Physical properties thereof, e.g. dissolubility
• CPC Class Codes: G01N 33/442 : Resins; Plastics
• CPC Class Codes: G01N 33/49 : Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80
• CPC Class Codes: G16H 40/67 : for remote operation
• CPC Class Codes: G16Z 99/00 : Subject matter not provided for in other main groups of this subclass
• CPC Class Codes: H01S 3/0092 : Nonlinear frequency conversion, e.g. second harmonic generation [SHG] or sum- or difference-frequency generation outside the laser cavity nonlinear frequency conversion per se G02F1/35
• CPC Class Codes: H01S 3/06758 : Tandem amplifiers
• CPC Class Codes: H01S 3/302 : in an optical fibre
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A wearable device for measuring physiological parameters includes a light source having a plurality of semiconductor light emitting diodes (LEDs) each configured to generate an output optical beam, wherein at least a portion of the one or more optical beam wavelengths is a near-infrared wavelength. The light source is configured to increase signal-to-noise ratio by increasing light intensity for at least one of the LEDs and by increasing a pulse rate of at least one of the LEDs. A lens is configured to receive the output optical beam and to deliver a lens output beam to tissue. A detection system generates an output signal in response to the lens output beam reflected from the tissue, wherein the detection system is configured to be synchronized to the light source, and is located a different distance from a first one of the LEDs than a second one of the LEDs.

Claims

1. A system comprising:

a light source comprising a plurality of light emitting diodes, each of the light emitting diodes configured to generate an output optical beam having one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers;

a lens positioned to receive at least a portion of at least one of the output optical beams and to deliver a lens output beam to tissue;

a detection system located to receive at least a portion of the lens output beam reflected from the tissue and configured to generate an output signal based on the received portion of the lens output beam reflected from the tissue, the output signal having a signal-to-noise ratio, wherein the detection system is further configured to be synchronized to the light source;

a personal device comprising a wireless receiver, a wireless transmitter, a display, a microphone, a speaker, one or more buttons or knobs, a microprocessor, and a touch screen, the personal device configured to receive and process at least a portion of the output signal, wherein the personal device is configured to store and display the processed output signal, and wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link; and

a remote device configured to receive over the wireless transmission link an output status comprising the at least a portion of the processed output signal, to process the received output status to generate processed data, and to store the processed data;

wherein the output signal is indicative of one or more physiological parameters, and the remote device is configured to store a history of at least a portion of the one or more physiological parameters over a specified period of time;

the light source configured to improve the signal-to-noise ratio of the output signal by increasing light intensity relative to an initial light intensity from at least one of the plurality of light emitting diodes and by increasing pulse rate relative to an initial pulse rate of at least one of the plurality of light emitting diodes;

wherein the detection system includes a plurality of spatially separated detectors, wherein at least one analog to digital converter is coupled to at least one of the spatially separated detectors and is configured to generate at least two data signals, and the system is configured to further improve the signal-to-noise ratio by differencing two of the at least two data signals; and

wherein the detection system further comprises one or more spectral filters positioned in front of at least some of the plurality of spatially separated detectors.

2. The system of claim 1 wherein the detection system is further configured to:

detect light while the light emitting diodes are off and generate a corresponding first signal;

detect light while at least one of the light emitting diodes is on and generate a corresponding second signal; and

further improve the signal-to-noise ratio of the output signal by differencing the first signal and the second signal.

3. The system of claim 1 wherein the output signal is generated by using a Fourier transform.

4. The system of claim 1 further comprising a reflective surface positioned to reflect at least a portion of light reflected from the tissue.

5. The system of claim 4, wherein the spatially separated detectors include at least one detector located at a distance from a first one of the light emitting diodes and at a different distance from a second one of the light emitting diodes, and is configured to generate a third signal responsive to light from the first light emitting diode and a fourth signal responsive to light from the second light emitting diode.

6. The system of claim 5, wherein the output signal is generated in part by comparing the third and fourth signals.

8. The system of claim 4, wherein the detection system is located at a distance from a first one of the light emitting diodes and at a different distance from a second one of the light emitting diodes such that the detection system receives a third signal from the first light emitting diode and a fourth signal from the second light emitting diode.

9. The system of claim 5, wherein the output signal is generated in part by comparing the third and fourth signals.

17. The system of claim 9, wherein the output signal is generated in part by comparing the third and fourth signals.

18. The system of claim 8, wherein the remote device is further configured to transmit at least a portion of the processed data to one or more other locations, wherein the one or more other locations is selected from the group consisting of the personal device, a doctor, a healthcare provider, a cloud-based server, and one or more designated recipients, and wherein the remote device is configured to transmit information related to a time and a position associated with the at least a portion of the processed data.

19. The system of claim 8, wherein at least one of the light emitting diodes emits light having a bandwidth between 20 nanometers and 40 nanometers.

20. The system of claim 8, further comprising one or more spectral filters positioned in front of one or more receivers of the detection system.

7. A system for measuring one or more physiological parameters comprising:

a light source comprising a plurality of semiconductor sources that are light emitting diodes, each of the light emitting diodes configured to generate an output optical beam having one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers;

a lens configured to receive a portion of at least one of the output optical beams and to deliver a lens output beam to tissue;

a detection system configured to receive at least a portion of the lens output beam reflected from the tissue and to generate an output signal having a signal-to-noise ratio, wherein the detection system is configured to be synchronized to the light source;

a personal device comprising a wireless receiver, a wireless transmitter, a display, a microphone, a speaker, one or more buttons or knobs, a microprocessor and a touch screen, the personal device configured to receive and process at least a portion of the output signal, wherein the personal device is configured to store and display the processed output signal, and wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link;

a remote device configured to receive over the wireless transmission link an output status comprising the at least a portion of the processed output signal, to process the received output status to generate processed data, and to store the processed data;

wherein the output signal is indicative of one or more of the physiological parameters, and the remote device is configured to store a history of at least a portion of the one or more physiological parameters over a specified period of time;

the system configured to increase the signal-to-noise ratio by increasing light intensity of at least one of the plurality of semiconductor sources from an initial light intensity and by increasing a pulse rate of at least one of the plurality of semiconductor sources from an initial pulse rate; and

the detection system further configured to;

generate a first signal responsive to light while the light emitting diodes are off,

generate a second signal responsive to light received while at least one of the light emitting diodes is on, and

increase the signal-to-noise ratio by differencing the first signal and the second signal.

10. The system of claim 7, further comprising a reflective surface configured to reflect at least a portion of light reflected from the tissue.

11. The system of claim 7 wherein the detection system comprises a plurality of spatially separated detectors.

12. The system of claim 11 wherein at least one of the spatially separated detectors is located at a distance from a first one of the light emitting diodes and at a different distance from a second one of the light emitting diodes, and is configured to generate a third signal responsive to light from the first light emitting diode and a fourth signal responsive to light from the second light emitting diode.

13. The system of claim 12 wherein the output signal is generated in part by comparing the third and fourth signals.

14. The system of claim 13 further comprising a reflective surface positioned to reflect at least a portion of light reflected from the tissue.

15. A system comprising:

a light source comprising a plurality of semiconductor sources that are light emitting diodes, each of the light emitting diodes configured to generate an output optical beam having one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers;

a lens configured to receive at least a portion of at least one of the output optical beams and to deliver a lens output beam to tissue;

a reflective surface configured to receive and redirect at least a portion of light reflected from the tissue;

a detection system configured to receive at least a portion of the lens output beam reflected from the tissue and to generate an output signal having a signal-to-noise ratio, wherein the detection system is configured to be synchronized to the light source;

a personal device comprising a wireless receiver, a wireless transmitter, a display, a microphone, a speaker, one or more buttons or knobs, a microprocessor and a touch screen, the personal device configured to receive and process at least a portion of the output signal, wherein the personal device is configured to store and display the processed output signal, and wherein at least a portion of the processed output signal is configured to be transmitted over a wireless transmission link; and

a remote device configured to receive over the wireless transmission link an output status comprising the at least a portion of the processed output signal, to process the received output status to generate processed data, and to store the processed data;

wherein the output signal represents one or more physiological parameters, and the remote device is configured to store a history of at least a portion of the one or more physiological parameters over a specified period of time;

the system configured to improve the signal-to-noise ratio by increasing light intensity from at least one of the light emitting diodes relative to an initial light intensity and by increasing a pulse rate of at least one of the light emitting diodes relative to an initial pulse rate; and

the detection system further configured to;

generate a first signal corresponding to light detected while the light emitting diodes are off,

generate a second signal corresponding to light detected while at least one of the light emitting diodes is on, and

increase the signal-to-noise ratio by differencing the first signal and the second signal.

16. The system of claim 15, wherein the detection system comprises at least on detector located at a distance from a first one of the light emitting diodes and at a different distance from a second one of the light emitting diodes such that the at least one detector generates a third signal from light from the first light emitting diode and a fourth signal from light from the second light emitting diode.