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Wearable, noninvasive glucose sensing methods and systems

  • US 10,188,325 B2
  • Filed: 11/27/2015
  • Issued: 01/29/2019
  • Est. Priority Date: 03/09/2012
  • Status: Active Grant
First Claim
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1. A wearable apparatus for glucose sensing comprising:

  • (a) a noninvasive glucose sensor, adapted to be in contact with or attached to a target tissue, comprising;

    (i) an ultrasound generator configured to direct ultrasound pulses or waves into the target tissue, and(ii) an ultrasound detector configured to;

    (1) detect ultrasound pulses or waves reflected from the target tissue using reflection, focused reflection, refraction, scattering, polarization, transmission, confocal, interferometric, low-coherence, and/or a low-coherence interferometry technique, and(2) generate a signal corresponding to the detected ultrasound pulses or waves,(b) a processor configured to;

    (i) receive the signal from the ultrasound detector,(ii) measure;

    (1) at least one time of flight of the ultrasound pulses or waves reflected from or transmitted through the target tissue evidencing boundaries or interfaces within the target tissue, and/or(2) at least one dimension of the target tissue evidencing a specific tissue layer within the target tissue, wherein the dimension includes thickness, length, width, diameter, curvature, or roughness; and

    (iii) determine a glucose concentration value from;

    (1) the at least one measured time of flight, and/or(2) the at least one measured dimension, and(c) a feedback unit including a display and configured to display a current glucose value or a plot of glucose values versus time,wherein the target tissue is associated with an arm, a forearm, a wrist, a shoulder, a hand, a palm, a finger, an abdomen, a chest, a neck, a head, an ear, an eye, a back, a leg, a foot, or mixtures and combinations thereof, andwherein target tissue comprises a skin tissue, an eye tissue, a mucosal tissue, a nail bed, a lunula, a connective tissue, a muscle tissue, a blood vessel, a cartilage tissue, a tendon tissue, or mixtures and combinations thereof.

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