Image-guided therapy of a tissue
First Claim
1. A method for effecting thermal therapy using an in vivo probe, comprising:
- positioning the probe in a volume in a patient;
identifying a three-dimensional region of interest at which to apply thermal therapy;
identifying, by processing circuitry, a treatment profile for effecting thermal therapy to the three-dimensional region of interest,wherein the treatment profile comprises a plurality of target positions,wherein each target position of the plurality of target positions is associated with one or more of a respective power level, a respective energy level, a respective emission pattern, a respective time period, and a respective geometry of a target area of the three-dimensional region of interest, and identifying the treatment profile comprises calculating the plurality of target positions as a sequence of positions and alignments of the probe based on a symmetric or asymmetric output pattern of the probe and selecting for the treatment profile a selected sequence corresponding to at least one of a minimum number of positions of the probe, and a minimum treatment time for effecting the thermal therapy to the three-dimensional region of interest based on expected output of the probe,wherein a desired trajectory of the probe is selected so as not to interfere with imaging equipment prior to the insertion of the probe into the volume; and
applying, by the processing circuitry, thermal therapy to the volume using the probe according to the treatment profile, wherein applying the thermal therapy comprisesa) activating delivery of therapeutic energy by the probe to the three-dimensional region of interest at a first target position of the plurality of target positions according to the treatment profile,b) causing actuation of the probe to adjust at least one of a linear position and a rotational position of the probe to a next target position of the plurality of target positions in accordance with the sequence of positions and alignments of the probe for each of the plurality of target positions in the treatment profile,c) activating delivery of therapeutic energy to the three-dimensional region of interest at the next target position according to the treatment profile, andd) repeating steps (b) and (c) until therapeutic energy is delivered to at least a first volume of the three-dimensional region of interest.
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Accused Products
Abstract
Image-guided therapy of a tissue can utilize magnetic resonance imaging (MRI) or another medical imaging device to guide an instrument within the tissue. A workstation can actuate movement of the instrument, and can actuate energy emission and/or cooling of the instrument to effect treatment to the tissue. The workstation and/or an operator of the workstation can be located outside a vicinity of an MRI device or other medical imaging device, and drive means for positioning the instrument can be located within the vicinity of the MRI device or the other medical imaging device. The instrument can be an MRI compatible laser probe that provides thermal therapy to, e.g., a tissue in a brain of a patient.
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Citations
19 Claims
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1. A method for effecting thermal therapy using an in vivo probe, comprising:
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positioning the probe in a volume in a patient; identifying a three-dimensional region of interest at which to apply thermal therapy; identifying, by processing circuitry, a treatment profile for effecting thermal therapy to the three-dimensional region of interest, wherein the treatment profile comprises a plurality of target positions, wherein each target position of the plurality of target positions is associated with one or more of a respective power level, a respective energy level, a respective emission pattern, a respective time period, and a respective geometry of a target area of the three-dimensional region of interest, and identifying the treatment profile comprises calculating the plurality of target positions as a sequence of positions and alignments of the probe based on a symmetric or asymmetric output pattern of the probe and selecting for the treatment profile a selected sequence corresponding to at least one of a minimum number of positions of the probe, and a minimum treatment time for effecting the thermal therapy to the three-dimensional region of interest based on expected output of the probe, wherein a desired trajectory of the probe is selected so as not to interfere with imaging equipment prior to the insertion of the probe into the volume; and applying, by the processing circuitry, thermal therapy to the volume using the probe according to the treatment profile, wherein applying the thermal therapy comprises a) activating delivery of therapeutic energy by the probe to the three-dimensional region of interest at a first target position of the plurality of target positions according to the treatment profile, b) causing actuation of the probe to adjust at least one of a linear position and a rotational position of the probe to a next target position of the plurality of target positions in accordance with the sequence of positions and alignments of the probe for each of the plurality of target positions in the treatment profile, c) activating delivery of therapeutic energy to the three-dimensional region of interest at the next target position according to the treatment profile, and d) repeating steps (b) and (c) until therapeutic energy is delivered to at least a first volume of the three-dimensional region of interest. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A system for effecting in vivo thermal therapy comprising:
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a processor; and a memory having instructions stored thereon, wherein the instructions, when executed by the processor, cause the processor to, while at least one probe is positioned within a volume in a patient; identify a treatment profile for effecting thermal therapy to a three-dimensional region of interest, wherein identifying comprises calculating a sequence of positions and alignments of the at least one probe based on a symmetric or asymmetric output pattern of the at least one probe and selecting for the treatment profile a selected sequence corresponding to at least one of a lowest number of positions of the at least one probe or a lowest treatment time for effecting the thermal therapy to the three-dimensional region of interest, wherein a desired trajectory of the at least one probe is selected so as not to interfere with imaging equipment prior to the insertion of the at least one probe into the volume, and apply thermal therapy to the volume using the at least one probe according to the treatment profile, wherein applying thermal therapy comprises a) activating delivery of therapeutic energy by the at least one probe to the three-dimensional region of interest at a first target position of a plurality of target positions, b) monitoring a respective temperature of each point of the at least one point at the first target position, wherein each point of the at least one point at the first target position is one of within the three-dimensional region of interest and adjacent to the three-dimensional region of interest, c) determining, based at least in part upon at least one of the respective temperature and a respective thermal dose of each of the at least one point at the first target position, completion of thermal therapy at the first target position, the respective thermal dose being based on a temperature history of each of the at least one point at the first target position over a specified time period, d) directing a probe driver to adjust at least one of a linear position and a rotational position of the at least one probe to a next target position of the plurality of target positions in accordance with a sequence of positions and alignments of the probe for each of the plurality of target positions in the treatment profile, e) activating delivery of therapeutic energy by the at least one probe to the three-dimensional region of interest at the next target position, f) monitoring at least one of the respective temperature and the respective thermal dose of each point of the at least one point at the next target position, wherein each point of the at least one point at the next target position is one of within the three-dimensional region of interest and adjacent to the three-dimensional region of interest, g) determining, based at least in part upon at least one of i) the respective temperature of each point of the at least one point at the next target position, and ii) the respective thermal dose of each point of the at least one point at the next target position, completion of treatment at the next target position, and h) repeating steps (c) through (g) until therapeutic energy is delivered to at least a first volume of the three-dimensional region of interest. - View Dependent Claims (15, 16, 17, 18)
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19. A non-transitory computer readable medium having instructions stored thereon, wherein the instructions, when executed by a processor, cause the processor to:
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identify a treatment profile for effecting thermal therapy to a three-dimensional region of interest, wherein identifying comprises calculating a first sequence of positions and alignments of a first probe based on a symmetric output pattern by the first probe, calculating a second sequence of positions and alignments of a second probe based on an asymmetric output pattern by the second probe, and selecting, for the treatment profile, one of the first sequence or the second sequence as a selected sequence having at least one of a lowest number positions of the probe or a lowest treatment time for effecting the thermal therapy to the three-dimensional region of interest and effect thermal therapy using a probe corresponding to the selected sequence, wherein effecting thermal therapy comprises a) identifying, from the treatment profile, a first emission level for treatment of the three-dimensional region of interest and a first position of the probe, b) activating delivery of therapeutic energy by the probe at the first emission level to the three-dimensional region of interest at the first position, c) monitoring feedback related to the first target area, wherein the feedback comprises at least one of temperature feedback and imaging feedback provided by at least one of a magnetic resonance (MR) imaging system and a thermometry imaging system, d) determining, based at least in part on the feedback, completion of thermal therapy at the first position, e) activating at least one of rotation and linear displacement of the probe to a next position in accordance with the sequence of positions and alignments of the probe in the treatment profile, f) identifying a next emission level for treatment of the three-dimensional region of interest at the next position of the probe, g) activating delivery of therapeutic energy by the probe at the next emission level to the three-dimensional region of interest at the next position according to the treatment profile, h) monitoring feedback related to the next target area, i) determining, based at least in part on the feedback, completion of thermal therapy at the next position, and j) repeating steps (f) through (i) until therapeutic energy is delivered to at least a first volume of the three-dimensional region of interest.
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Specification