Peptide conjugated particles
First Claim
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1. A composition comprising surface functionalized biodegradable particles comprising encapsulated allergen or one or more antigenic epitopes thereof, wherein the particle has a negative zeta potential of about −
- 100 mV to about −
30 mV.
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Abstract
The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
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Citations
30 Claims
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1. A composition comprising surface functionalized biodegradable particles comprising encapsulated allergen or one or more antigenic epitopes thereof, wherein the particle has a negative zeta potential of about −
- 100 mV to about −
30 mV. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 24, 25, 29)
- 100 mV to about −
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12. A composition comprising surface functionalized biodegradable PLG particles comprising encapsulated allergen or one or more antigenic epitopes thereof wherein said PLG particles have a copolymer ratio of about 50:
- 50 poly(lactide-co-glycolide), a diameter of about 200 nm to about 2000 nm and a zeta potential of about −
30 my to about −
80 mV.
- 50 poly(lactide-co-glycolide), a diameter of about 200 nm to about 2000 nm and a zeta potential of about −
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13. A lyophilized composition comprising surface functionalized biodegradable particles comprising encapsulated allergen or one or more antigenic epitopes thereof, wherein the particle has a negative zeta potential of about −
- 100 mV to about −
30 mV. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 26, 27, 30)
- 100 mV to about −
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23. A lyophilized composition comprising surface functionalized biodegradable PLG particles comprising encapsulated allergen or one or more antigenic epitopes thereof wherein said PLG particles have a copolymer ratio of about 50:
- 50 poly(lactide-co-glycolide), a diameter of about 200 nm to about 2000 nm and a zeta potential of about −
30 my to about −
80 mv. - View Dependent Claims (28)
- 50 poly(lactide-co-glycolide), a diameter of about 200 nm to about 2000 nm and a zeta potential of about −
Specification