Conjugates for imaging

• US 10,188,759 B2
• Filed: 01/06/2016
• Issued: 01/29/2019
• Est. Priority Date: 01/07/2015
• Status: Active Grant

• Current Assignee: Endocyte, Inc. (Novartis Ag)
• Original Assignee: Endocyte, Inc. (Novartis Ag)
• Inventors: Vlahov, Iontcho R., Leamon, Christopher P., Santhapuram, Hari Krishna R.
• Primary Examiner(s): Katakam, Sudhakar
• Application Number:
  US14/989,498
• Publication Number:
  US 20160193371A1
• Time in Patent Office: 1,119 Days
• CPC Class Codes: A61K 51/02 characterised by the carrier , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
• CPC Class Codes: A61K 51/0459 having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine

Abstract

The invention described herein relates to conjugates and compositions for imaging, diagnosing, and/or monitoring diseases using radionuclide-based imaging. In particular, the invention described herein relates to conjugates and compositions for imaging, diagnosing, and/or monitoring diseases using positron emission tomography.

Claims

1. A conjugate, or a pharmaceutically acceptable salt thereof, of the formula

2. The conjugate of claim 1 of the formula

3. The conjugate of claim 1 of the formula

4. The conjugate of claim 1 of the formula

5. The conjugate of claim 1 wherein the conjugate, or pharmaceutically acceptable salt thereof, is complexed with ⁸⁹Zr.

6. A composition comprising a conjugate, or a pharmaceutically acceptable salt thereof, of claim 1.

7. A kit comprising a conjugate, or a pharmaceutically acceptable salt thereof, of claim 1.