Blood glucose control system
First Claim
1. A sensor-driven glucose control system, comprising:
- an insulin delivery device operative in response to an insulin dose control signal to infuse insulin into the subject; and
a controller operative to generate the insulin dose control signal by;
(1) continually administering priming doses of insulin at respective times, each priming dose being of a respective amount and having a prescribed interval of action;
(2) receiving information regarding total amounts of insulin administered during the prescribed intervals of action, each total amount including an aggregation of total doses administered in response to a glucose level signal; and
(3) automatically adapting the amounts of the priming doses in response to a mathematical relationship, over respective periods each spanning multiple prescribed intervals of action, between the amounts of the priming doses and the total amounts of insulin administered during the prescribed intervals of action.
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Accused Products
Abstract
Techniques are used for adaptation of drug-administration parameters that control insulin delivery in a blood glucose control system. One technique provides long-term adaptation of a nominal basal infusion rate, adapting to longer-term changes in a patient'"'"'s needs due to growth, illness, hormonal fluctuations, physical activity, aging, etc. Another technique provides adaptation of priming dose size at mealtimes for overall better glycemic control and also adapting to longer-term changes in a patient'"'"'s needs. Adaptation calculations use a receding-horizon window of recent values of the adapted parameter. Doses of a counter-regulatory agent (e.g., glucagon) may also be delivered in response to information about estimated accumulation of exogenously infused insulin (subcutaneously, intramuscularly, intraperitoneally, or intravenously) and/or the effect insulin might have on glucose levels (blood glucose concentration or interstitial fluid glucose concentration).
19 Citations
14 Claims
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1. A sensor-driven glucose control system, comprising:
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an insulin delivery device operative in response to an insulin dose control signal to infuse insulin into the subject; and a controller operative to generate the insulin dose control signal by; (1) continually administering priming doses of insulin at respective times, each priming dose being of a respective amount and having a prescribed interval of action; (2) receiving information regarding total amounts of insulin administered during the prescribed intervals of action, each total amount including an aggregation of total doses administered in response to a glucose level signal; and (3) automatically adapting the amounts of the priming doses in response to a mathematical relationship, over respective periods each spanning multiple prescribed intervals of action, between the amounts of the priming doses and the total amounts of insulin administered during the prescribed intervals of action. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of operating a controller for a sensor-driven glucose control system including an insulin delivery device operative in response to an insulin dose control signal to infuse insulin into the subject, comprising:
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generating the insulin dose control signal to continually administer priming doses of insulin at respective times, each priming dose being of a respective amount and having a prescribed interval of action; receiving information regarding total amounts of insulin administered during the prescribed intervals of action, each total amount including an aggregation of total doses administered in response to a glucose level signal; and automatically adapting the amounts of the priming doses in response to a mathematical relationship, over respective periods each spanning multiple prescribed intervals of action, between the amounts of the priming doses and the total amounts of insulin administered during the prescribed intervals of action. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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Specification