Targeting therapeutic agents

• US 10,188,805 B2
• Filed: 06/09/2015
• Issued: 01/29/2019
• Est. Priority Date: 08/03/2009
• Status: Active Grant

• Current Assignee: Emory University
• Original Assignee: Emory University
• Inventors: Galloway, Niall, Galloway, James
• Primary Examiner(s): Henson, Devin
• Application Number:
  US14/734,087
• Publication Number:
  US 20150265778A1
• Time in Patent Office: 1,330 Days
• CPC Class Codes: A61B 1/307 for the urinary organs, e.g. urethroscopes, cystoscopes
• CPC Class Codes: A61B 17/0482 Needle or suture guides guides for drills, pins or wire A61B17/17; for puncturing needles A61B17/3403
• CPC Class Codes: A61B 17/3403 Needle locating or guiding means guides for suture needles A61B17/0482; guiding or tracking by nuclear magnetic resonance G01R33/285
• CPC Class Codes: A61B 17/42 Gynaecological or obstetrical instruments or methods ligaturing clamps or clips for the umbilical cord A61B17/122; curettage A61B17/320708; dilators A61M29/00
• CPC Class Codes: A61B 17/4241 Instruments for manoeuvring or retracting the uterus, e.g. during laparoscopic surgery
• CPC Class Codes: A61B 2017/00805 Treatment of female stress urinary incontinence
• CPC Class Codes: A61B 2017/3405 using mechanical guide means
• CPC Class Codes: A61B 2017/3407 including a base for support on the body
• CPC Class Codes: A61B 2017/3411 with a plurality of holes, e.g. holes in matrix arrangement
• CPC Class Codes: A61B 2018/00517 Urinary bladder or urethra
• CPC Class Codes: A61B 2018/00523 Treatment of incontinence
• CPC Class Codes: A61B 5/1076 for measuring dimensions inside body cavities, e.g. using catheters A61B3/1005 takes precedence
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61M 2202/06 Solids
• CPC Class Codes: A61M 2210/1089 Urethra
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61M 25/01 Introducing, guiding, advancing, emplacing or holding catheters A61M25/10 takes precedence
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104
• CPC Class Codes: A61M 5/3287 Accessories for bringing the needle into the body; Automatic needle insertion A61M5/20, A61M5/31525 take precedence

Abstract

Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration of peri-urethral bulking agents.

Claims

1. A method for targeting administration of a therapeutic agent to a subject, comprising:

inserting a device including a sleeve defining a lumen and a frame disposed about an end of the sleeve into an organ lumen of an organ;

wherein the frame includes more than one arm extending from the end of the sleeve;

wherein the frame shapes a concavity into an outer wall of the organ between a first arm and a second arm of the frame;

guiding an administration device through a guide apparatus disposed on the sleeve so that the administration device is guided external to the organ lumen and the sleeve, between the first arm and the second arm, and proximate to the shaped concavity; and

administering a therapeutic agent into the shaped concavity.

2. The method of claim 1, wherein the frame has a first retracted configuration and a second extended configuration, the first retracted configuration adapted for insertion into the lumen and the second extended configuration adapted to shape the concavity into the outer wall of the organ;

and, further comprising;

actuating the frame from the first retracted configuration to the second extended configuration to cause the first arm and the second arm to shape the concavity into the outer wall of the organ;

wherein the administration device is guided through the guiding member when the frame is in the second extended configuration.

3. The method of claim 1, wherein the organ is a urethra, rectum or anus.

4. The method of claim 1, wherein the therapeutic agent is a bulking agent.

5. The method of claim 2, wherein the frame shapes a plurality of concavities into another wall of the organ in the second extended configuration.

6. The method of claim 5, further comprising administering a therapeutic agent into a plurality of the shaped concavities.

7. The method of claim 1, wherein the guide apparatus includes a guiding member that is slidable along the sleeve, the method further comprising:

determining a length of the organ; and

positioning the guiding member with respect to the sleeve using at least the length of the organ;

wherein the administration device is guided until a portion of the administration device abuts the guide apparatus.

8. A method for targeting administration of a therapeutic agent to a subject, comprising:

inserting a device including a sleeve defining a lumen and a frame disposed about an end of the sleeve into an organ lumen of an organ, the frame including more than one arm extending from the end;

expanding the frame from a first retracted configuration to a second extended configuration to shape a concavity into an outer wall of the organ between a first arm and a second arm of the frame;

guiding an administration device through a guide apparatus disposed on the sleeve so that the administration device is guided external to the organ lumen and the sleeve, between the first arm and the second arm, and proximate to the shaped concavity; and

administering a therapeutic agent into the shaped concavity.

9. The method of claim 8, wherein the organ is a urethra, rectum or anus.

10. The method of claim 8, wherein the therapeutic agent is a bulking agent.

11. The method of claim 8, wherein the frame shapes a plurality of concavities into another wall of the organ in the second extended configuration;

and the method further comprises;

administering a therapeutic agent into a plurality of the shaped concavities.

12. The method of claim 8, wherein the guide apparatus includes a guiding member that is slidable along the sleeve, the method further comprising:

determining a length of the organ; and

positioning the guiding member with respect to the sleeve using at least the length of the organ;

wherein the administration device is guided until a portion of the administration device abuts the guide apparatus.

13. The method of claim 8, further comprising:

inserting an optical device through the lumen of the sleeve.

14. The method of claim 13, wherein the frame is expanded when the optical device is advanced through the lumen of the sleeve.

15. A method for targeting administration of a therapeutic agent to a subject, comprising:

inserting a device including a sleeve defining a lumen and a frame disposed about an end of the sleeve into an organ lumen of an organ, the frame including more than one arm extending from the end;

advancing an actuator through the lumen of the sleeve to expand the frame from a first retracted configuration to a second extended configuration to shape a concavity into an outer wall of the organ between a first arm and a second arm of the frame;

guiding an administration device through a guide apparatus disposed on the sleeve so that the administration device is guided external to the organ lumen and the sleeve, between the first arm and the second arm, and proximate to the shaped concavity; and

administering a therapeutic agent into the shaped concavity.

16. The method of claim 15, wherein the organ is a urethra, rectum or anus.

17. The method of claim 15, wherein the therapeutic agent is a bulking agent.

18. The method of claim 15, wherein the frame shapes a plurality of concavities into another wall of the organ in the second extended configuration;

and the method further comprises;

administering a therapeutic agent into a plurality of the shaped concavities.

19. The method of claim 15, wherein the guide apparatus includes a guiding member that is slidable along the sleeve, the method further comprising:

determining a length of the organ; and

positioning the guiding member with respect to the sleeve using at least the length of the organ;

wherein the administration device is guided until a portion of the administration device abuts the guide apparatus.

20. The method of claim 15, wherein the actuator is an optical device.