Aortic cannula for ex vivo organ care system

• US 10,194,655 B2
• Filed: 09/07/2016
• Issued: 02/05/2019
• Est. Priority Date: 09/09/2015
• Status: Active Grant

• Current Assignee: TransMedics, Inc. (TransMedics Group, Inc.)
• Original Assignee: TransMedics, Inc. (TransMedics Group, Inc.)
• Inventors: Ritchie, Greg, Lambert, II, Vincent, Bringham, Richard, Sullivan, John, Hassanein, Waleed H.
• Primary Examiner(s): Wiest, Philip R
• Application Number:
  US15/258,194
• Publication Number:
  US 20170064943A1
• Time in Patent Office: 881 Days
• Field of Search: 604 616
• CPC Class Codes: A01N 1/0247 for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts

Abstract

The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.

Claims

1. An aortic cannula for use in an ex vivo organ care system comprising:

a cannula body comprising;

a fitting adapted to connect to an organ care system, and

an aorta interface to contact an aorta;

a pivot arm strap operably connected to a pivot mount, wherein the pivot mount allows the pivot arm strap to uniformly contact the aorta to hold the aorta on the aorta interface; and

a spring which applies pressure to the pivot arm strap to hold the aorta on the aorta interface.

2. The aortic cannula of claim 1, further comprising a pivot arm connected to the pivot arm strap and to the pivot mount, such that when the pivot arm is moved toward the cannula body by rotation around the pivot mount the pivot arm strap moves away from the cannula body.

3. The aortic cannula of claim 2 wherein the pivot arm and the pivot arm strap are parts of a single piece.

4. The aortic cannula of claim 1 wherein a dowel pin communicates with the spring to allow the pivot arm to rotate around the dowel pin.

5. The aortic cannula of claim 2 wherein the pivot arm further comprises a grip pad used to depress the top of the pivot arm.

6. The aortic cannula of claim 5 wherein the grip pad is textured.

7. The aortic cannula of claim 5 wherein the grip pad is removable.

8. The aortic cannula of claim 1 wherein the pivot arm strap further comprises a loop and guide which retain a cable tie around the pivot arm strap.

9. The aortic cannula of claim 8 further comprising windows sized to normalize the compression exerted on the aorta by the cable tie such that the same amount of pressure will be exerted on the aorta regardless of the size of the pivot arm strap for a given cable tie tension.

10. The aortic cannula of claim 1 further comprising a connector used to reversibly secure the aortic cannula to an organ chamber.

11. The aortic cannula of claim 10 wherein the connector is a threaded locking nut.

12. The aortic cannula of claim 1 wherein the aorta interface is textured.

13. An aortic cannula for use in an ex vivo organ care system, comprising:

a locking nut configured to reversibly secure the aortic cannula to an organ chamber assembly;

a cannula body, comprising;

a tapered fitting sized to connect to an organ chamber assembly;

an aorta interface sized to fit within an aorta; and

a tapered midsection extending from the tapered fitting to the aorta interface; and

a pivot mount;

a pivot arm operably connected to the pivot mount, the pivot arm comprising;

a grip pad that can be used to depress a top of the pivot arm;

a pivot arm strap configured to hold the aorta against the aorta interface; and

a sliding pivot window configured to allow the pivot arm strap to maintain contact with the aorta through a range of motion; and

a dowel pin allows the pivot mount to connect to the sliding pivot window;

wherein the pivot arm is configured to rotate around the dowel pin.

14. The aortic cannula of claim 13 further comprising a tip holder configured to connect to the locking nut.

15. The aortic cannula of claim 13 wherein the aortic interface is textured.

16. The aortic cannula of claim 13 further comprising a spring which applies pressure to the pivot arm strap to hold the aorta on the aorta interface.

17. The aortic cannula of claim 16 wherein the grip pad compresses the spring when depressed.

18. The aortic cannula of claim 13 wherein the pivot arm strap further comprises a loop and guide which retain a cable tie around the pivot arm strap.

19. The aortic cannula of claim 18 further comprising windows sized to normalize the compression exerted on the aorta by the cable tie such that the same amount of pressure will be exerted on the aorta regardless of the size of the pivot arm strap for a given cable tie tension.

20. A method of using an aortic cannula to place a heart in fluid communication with an organ care system the method comprising:

selecting an aortic cannula sized to fit an aorta of the heart the aortic cannula comprising;

a cannula body comprising;

a fitting adapted to connect to an organ care system; and

an aorta interface to contact an aorta; and

a pivot arm strap operably connected to a pivot mount, wherein the pivot mount allows the pivot arm strap to uniformly contact the aorta to hold the aorta on the aorta interface;

depressing the pivot arm such that the pivot arm rotates around a dowel pin and the pivot arm strap moves away from the cannula body, wherein the dowel pin allows the pivot mount to operably connect to the pivot arm;

placing the aorta interface in the aorta;

releasing the pivot arm;

tightening a cable tie around the pivot arm strap to hold the aorta in place around the aorta interface; and

inserting the tapered fitting into an organ care system.

21. The method of claim 20 further comprising the step of suturing surgical felt pledgets on the aorta before placing the aorta on the aortic cannula.

22. The method of claim 20 further comprising using a locking nut to reversibly secure the aortic cannula to the organ care system.