Integrated electronics for photoplethysmography and electrocardiography

• US 10,194,809 B2
• Filed: 08/24/2015
• Issued: 02/05/2019
• Est. Priority Date: 08/24/2015
• Status: Active Grant

• Current Assignee: Google LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Mirov, Russell Norman, Joseph, John Navil
• Primary Examiner(s): Johnson, Nicole F
• Application Number:
  US14/833,195
• Publication Number:
  US 20170055845A1
• Time in Patent Office: 1,261 Days
• Field of Search: 600509, 600513
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02427 Details of sensor
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/332 Portable devices specially adapted therefor
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: A61B 5/7225 Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation A61B5/30, A61B5/316 take precedence; transformers for specific applications H01F38/00; amplifiers H03F
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

Devices and systems are provided to electrically and optically detect hemodynamic properties of a body. Such devices are configured to detect electrocardiographic signals and photoplethysmographic signals and to operate a single analog-to-digital converter (ADC) to sample one or more of each of such signals. This includes operating a multiplexer to connect electrical signals related to the detected optical and electrical properties to the single ADC during respective different sampling times or periods. This can include connecting the detected electrocardiographic signals and photoplethysmographic signals to the ADC during alternating periods of time. Using a single ADC to sample one or more of each of electrocardiographic signals and photoplethysmographic signals can provide samples of such signals that have a relative timing that is known, stable, and controllable.

Claims

1. A system comprising:

a light emitter, wherein the light emitter is configured to illuminate a portion of subsurface vasculature via an external body surface;

a photodetector, wherein the photodetector is configured to receive light emitted from the portion of subsurface vasculature responsive to illumination by the light emitter;

an electrocardiogram sensor, wherein the electrocardiogram sensor is configured to detect an electrocardiographic signal via the external body surface;

an amplifier;

a multiplexer, wherein the multiplexer is electrically connected to an output of the photodetector, an output of the electrocardiogram sensor, and an input of the amplifier, and wherein the multiplexer is controllable to selectively connect the output of the photodetector and the output of the electrocardiogram sensor to the input of the amplifier;

an analog-to-digital converter, wherein the analog-to-digital converter is configured to generate digital codes based on an output of the amplifier; and

a controller, wherein the controller is configured to perform controller operations comprising;

operating the light emitter, during a first plurality of specified periods of time, to illuminate the portion of subsurface vasculature;

operating the multiplexer, during the first plurality of specified periods of time, to connect the output of the photodetector to the input of the amplifier;

operating the analog-to-digital converter to generate a first plurality of digital codes based on the output of the amplifier during the first plurality of specified periods of time;

operating the multiplexer, during a second plurality of specified periods of time, to connect the output of the electrocardiogram sensor to the input of the amplifier, wherein the second plurality of specified periods of time are offset in time from the first plurality of specified periods of time; and

operating the analog-to-digital converter to generate a second plurality of digital codes based on the output of the amplifier during the second plurality of specified periods of time.

2. The system of claim 1, wherein the external body surface is a wrist location.

3. The system of claim 1, further comprising:

a display, wherein the controller operations further include operating the display to provide an indication based on at least one digital code generated by the analog-to-digital converter.

4. The system of claim 1, wherein the analog-to-digital converter is a sigma-delta analog-to-digital converter.

5. The system of claim 1, wherein the amplifier is a transimpedance amplifier and the photodetector is a photodiode.

6. The system of claim 1, further comprising at least one electrical contact connected to the electrocardiogram sensor and a mount configured to mount the light emitter, photodetector, and at least one electrical contact proximate to the external body surface.

7. The system of claim 1, further comprising:

a further light emitter, wherein the further light emitter is configured to illuminate the portion of subsurface vasculature via the external body surface, wherein the photodetector is configured to receive light emitted from the portion of subsurface vasculature responsive to illumination by the further light emitter, and wherein the controller operations further comprise;

operating the further light emitter, during a third plurality of specified periods of time, to illuminate the portion of subsurface vasculature;

operating the multiplexer, during the third plurality of specified periods of time, to connect the output of the photodetector to the input of the amplifier;

operating the analog-to-digital converter to generate a third plurality of digital codes based on the output of the amplifier during the third plurality of specified periods of time.

8. The system of claim 7, wherein the controller operations further comprise determining a blood oxygenation based on the first plurality of digital codes and the third plurality of digital codes.

9. The system of claim 1, wherein the controller operations further comprise determining a pulse transit time based on the first plurality of digital codes and the second plurality of digital codes.

10. The system of claim 1, wherein the amplifier and the analog-to-digital converter are provided on a single integrated circuit.

11. The system of claim 1, further comprising:

a transmitter, wherein the controller operations further include operating the transmitter to provide a wireless indication based on at least one digital code generated by the analog-to-digital converter.

12. The system of claim 1, wherein the controller operations further comprise determining a pulse rate based on the first plurality of digital codes or the second plurality of digital codes.

13. The system of claim 1, wherein the controller operations further comprise determining a blood pressure based on at least one of the first plurality of digital codes or the second plurality of digital codes.

14. A method comprising:

illuminating, by a light emitter operated by a controller during a first plurality of specified periods of time, a portion of subsurface vasculature via an external body surface;

connecting, by a multiplexer operated by the controller during the first plurality of specified periods of time, an output of a photodetector to an input of an amplifier, wherein the photodetector is configured to receive light emitted from the portion of subsurface vasculature responsive to illumination by the light emitter;

generating, by an analog-to-digital converter operated by the controller during the first plurality of specified periods of time, a first plurality of digital codes based on the output of the amplifier;

connecting, by the multiplexer operated by the controller during a second plurality of specified periods of time, an output of an electrocardiogram sensor to the input of the amplifier, wherein the second plurality of specified periods of time are offset in time from the first plurality of specified periods of time, and wherein the electrocardiogram sensor is configured to detect an electrocardiographic signal via the external body surface; and

generating, by the analog-to-digital converter operated by the controller during the second plurality of specified periods of time, a second plurality of digital codes based on the output of the amplifier.

15. The method of claim 14, further comprising:

providing an indication based on at least one digital code generated by the analog-to-digital converter.

16. The method of claim 14, further comprising:

illuminating, by a further light emitter operated by the controller during a third plurality of specified periods of time, the portion of subsurface vasculature via the external body surface;

connecting, by the multiplexer operated by the controller during the third plurality of specified periods of time, the output of the photodetector to the input of the amplifier, wherein the photodetector is configured to receive light emitted from the portion of subsurface vasculature responsive to illumination by the further light emitter; and

generating, by the analog-to-digital converter operated by the controller during the third plurality of specified periods of time, a third plurality of digital codes based on the output of the amplifier.

17. The method of claim 14, further comprising:

determining a pulse transit time based on the first plurality of digital codes and the second plurality of digital codes.

18. The method of claim 14, further comprising:

providing a wireless indication based on at least one digital code generated by the analog-to-digital converter.

19. The method of claim 14, further comprising:

determining a pulse rate based on the first plurality of digital codes or the second plurality of digital codes.

20. The method of claim 14, further comprising:

determining a blood pressure based on the first plurality of digital codes or the second plurality of digital codes.