Accuracy of continuous glucose sensors
First Claim
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1. A method for improving accuracy of a continuous glucose sensor (CGS), comprising:
- calibrating the CGS at a first time;
dynamically monitoring a CGS value and a rate of CGS change over time;
determining, at a second time, whether a first condition is met, wherein the first condition is met if an absolute value of the rate of CGS change at the second time is less than a first predetermined value, and wherein the absolute value of the rate of CGS change is an absolute value of a first order time derivative of the CGS value;
in response to the first condition not being met, maintaining the calibration of the CGS at the first time;
in response to the first condition being met, determining whether a second condition is met;
in response to a determination that the first condition and the second condition are met, calibrating the CGS at the second time.
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Abstract
A method, apparatus, and a kit are capable of improving accuracy of CGS devices using dynamic outputs of continuous glucose sensors.
793 Citations
16 Claims
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1. A method for improving accuracy of a continuous glucose sensor (CGS), comprising:
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calibrating the CGS at a first time; dynamically monitoring a CGS value and a rate of CGS change over time; determining, at a second time, whether a first condition is met, wherein the first condition is met if an absolute value of the rate of CGS change at the second time is less than a first predetermined value, and wherein the absolute value of the rate of CGS change is an absolute value of a first order time derivative of the CGS value; in response to the first condition not being met, maintaining the calibration of the CGS at the first time; in response to the first condition being met, determining whether a second condition is met; in response to a determination that the first condition and the second condition are met, calibrating the CGS at the second time. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for improving the accuracy of a glucose sensor, comprising:
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requesting and receiving a first blood glucose reference value when the glucose sensor measures a first in vivo glucose value; calibrating the glucose sensor using the first blood glucose reference value and the first in vivo glucose value; measuring, by the glucose sensor, a second in vivo glucose value and a rate of in vivo glucose change; determining if an absolute rate of in vivo glucose change value is less than a first predetermined value; determining if an absolute difference between the second in vivo glucose value and the first in vivo glucose value is greater than a second predetermined value; in response to a determination that the absolute rate of in vivo glucose change value is less than the first predetermined value, and a determination that the absolute difference between the second in vivo glucose value and the first in vivo glucose value is greater than the second predetermined value, requesting and receiving a second blood glucose reference value; and calibrating the glucose sensor using the second blood glucose reference value and the second in vivo glucose value, wherein the absolute rate of in vivo glucose change value is based on a first order time derivative of the second in vivo glucose value.
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14. A system for improving an accuracy of a glucose sensor, comprising:
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at least one processing unit; memory coupled to the at least one processing unit, wherein the memory is configured to store program modules and instructions comprising; an accuracy improving module accessible to an output of the glucose sensor, further comprising; a decision making mechanism capable of determining a calibration at a second time based upon at least one of a dynamically monitored output of the glucose sensor, wherein the decision making mechanism is configured to; determine if an absolute rate of in vivo glucose change value at the second time is less than a first predetermined value, determine if an absolute difference between an in vivo glucose value at the second time and an in vivo glucose value at a first time is greater than a second predetermined value, and in response to a determination that the absolute rate is less than the first predetermined value, and the absolute difference is greater than the second predetermined value, calibrating the glucose sensor, wherein the absolute rate of in vivo glucose change value is based on a first order time derivative of the in vivo glucose value at the second time. - View Dependent Claims (15, 16)
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Specification