Implantation devices including hydrogel filaments

• US 10,194,915 B2
• Filed: 09/21/2016
• Issued: 02/05/2019
• Est. Priority Date: 12/21/2007
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Cruise, Gregory M., Constant, Michael J., Keeley, Edward Michael, Tran, Terrance T.
• Primary Examiner(s): Tran, Susan T
• Assistant Examiner(s): Craigo, William
• Application Number:
  US15/272,305
• Publication Number:
  US 20170007264A1
• Time in Patent Office: 867 Days
• Field of Search: None
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12181 formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable or resorptive
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61K 49/0404 containing barium sulfate
• CPC Class Codes: A61L 24/001 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 24/0031 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C08L 71/02 Polyalkylene oxides

Abstract

Described are devices for implantation comprising a hydrogel filament wherein the hydrogel filament includes a low molecular weight ethylenically unsaturated macromer, an ethylenically unsaturated monomer, and a visualization agent. Methods of making and using these devices are also described.

Claims

1. A device for implantation comprising:

a hydrogel filament attached to a coupler wherein the coupler is attached to a pusher,

wherein the hydrogel filament includes a low molecular weight ethylenically unsaturated macromer;

an ethylenically unsaturated monomer; and

visualization agent having a structure of 2,4,6-triiodophenyl penta-4-enoate,

wherein said device contains no support members.

2. The device of claim 1, wherein said macromer has a molecular weight of about 100 grams/mole to about 5000 grams/mole.

3. The device of claim 1, wherein said macromer comprises polyethylene glycol, propylene glycol, poly(tetramethylene oxide), poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) di methacrylate, derivatives thereof, or combinations thereof.

4. The device of claim 1, wherein said macromer and said monomer are crosslinked with N,N,N′

,N′

-tetramethylethylenediamine, ammonium persulfate, azobisisobutyronitrile, benzoyl peroxides, 2,2′

-azobis(2-methylpropionamidine) dihydrochloride, derivatives thereof, or combinations thereof.

5. The device of claim 1, wherein said hydrogel is substantially free of acrylamide.

6. The device of claim 1, wherein said hydrogel is substantially non-bioresorbable.

7. The device of claim 1, wherein said visualization agent is at a concentration of about 40% w/w to about 80% w/w of a prepolymer solution used to form the hydrogel filament.

8. A device for implantation comprising:

an introducer loaded with a hydrogel filament, wherein the introducer attaches to a catheter or microcatheter,

wherein the hydrogel filament includes a low molecular weight ethylenically unsaturated macromer;

an ethylenically unsaturated monomer; and

visualization agent having a structure of 2,4,6-triiodophenyl penta-4-enoate,

wherein said device contains no support members.

9. The device of claim 8, wherein said macromer has a molecular weight of about 100 grams/mole to about 5000 grams/mole.

10. The device of claim 8, wherein said macromer comprises polyethylene glycol, propylene glycol, poly(tetramethylene oxide), poly(ethylene glycol) diacrylamide, poly(ethylene glycol) diacrylate, poly(ethylene glycol) di methacrylate, derivatives thereof, or combinations thereof.

11. The device of claim 8, wherein said macromer and said monomer are crosslinked with N,N,N′

,N′

-tetramethylethylenediamine, ammonium persulfate, azobisisobutyronitrile, benzoyl peroxides, 2,2′

-azobis(2-methylpropionamidine) dihydrochloride, derivatives thereof, or combinations thereof.

12. The device of claim 8, wherein said hydrogel is substantially free of acrylamide.

13. The device of claim 8, wherein said hydrogel is substantially non-bioresorbable.

14. The device of claim 8, wherein said visualization agent is at a concentration of about 40% w/w to about 80% w/w of a prepolymer solution used to form the hydrogel filament.