Use of remote ischemic conditioning for traumatic injury
First Claim
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1. A method for treating a subject experiencing hemorrhagic shock to protect an organ of the subject from effects associated with hemorrhagic shock, comprising:
- performing non-invasive, individual or repeated remote ischemic conditioning (RIC) regimens on a subject experiencing hemorrhagic shock, before performance of resuscitation therapy, wherein the RIC regimens are performed on a limb of a subject remote from the organ, wherein each RIC regimen comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle of blood flow occlusion has duration of one minute or more and wherein each subsequent cycle begins upon conclusion of reperfusion of a previous cycle.
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Abstract
The invention provides methods for reducing traumatic injury through the use of ischemic conditioning.
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Citations
20 Claims
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1. A method for treating a subject experiencing hemorrhagic shock to protect an organ of the subject from effects associated with hemorrhagic shock, comprising:
performing non-invasive, individual or repeated remote ischemic conditioning (RIC) regimens on a subject experiencing hemorrhagic shock, before performance of resuscitation therapy, wherein the RIC regimens are performed on a limb of a subject remote from the organ, wherein each RIC regimen comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle of blood flow occlusion has duration of one minute or more and wherein each subsequent cycle begins upon conclusion of reperfusion of a previous cycle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for treating a subject for systemic effects associated with hemorrhagic shock caused to protect one or more organs of the subject, comprising:
performing two or more cycles of non-invasive remote blood flow occlusion followed by reperfusion on a subject experiencing hemorrhagic shock, before onset of ischemia and performance of resuscitation therapy, wherein the two or more cycles of non-invasive remote blood flow occlusion followed by reperfusion are performed on a limb of the subject remote from the one or more organs, wherein each cycle of blood flow occlusion has a duration of one minute or more and wherein each subsequent cycle begins upon conclusion of reperfusion of a previous cycle.
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20. A method for treating a subject who is experiencing hemorrhagic shock and ischemia to reduce or prevent systemic effects associated with hemorrhagic shock to protect one or more organs, comprising performing individual or repeated remote ischemic conditioning (RIC) regimens on the subject before onset of ischemia and performance of resuscitation therapy, wherein the RIC regimens are performed on a limb of the subject remote from the one or more organs, wherein each RIC regimen comprises two or more cycles of blood flow occlusion followed by reperfusion, wherein each cycle of blood flow occlusion has a duration of one minute or more and wherein each subsequent cycle begins upon conclusion of reperfusion of a previous cycle.
Specification