Adjustable intraocular implant

• US 10,195,079 B2
• Filed: 05/17/2016
• Issued: 02/05/2019
• Est. Priority Date: 02/19/2013
• Status: Active Grant

• Current Assignee: AqueSys, Inc. (Abbvie Incorporated)
• Original Assignee: AqueSys, Inc. (Abbvie Incorporated)
• Inventors: Horvath, Christopher, Romoda, Laszlo O., Hamstrom, Brian, Bache, Ronald D., Grabner, Guenther, Reitsamer, Herbert A.
• Primary Examiner(s): Zalukaeva, Tatyana
• Assistant Examiner(s): Weng, Kai
• Application Number:
  US15/157,240
• Publication Number:
  US 20160256322A1
• Time in Patent Office: 994 Days
• CPC Class Codes: A61F 2009/00891 Glaucoma
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00736 Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments A61F9/008 takes precedence
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61L 31/08 Materials for coatings
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202

Abstract

Methods and devices for adjusting or configuring the flow rate of an intraocular shunt are provided whereby hypotony can be avoided by increasing the flow rate through the device. In some embodiments, the device is a shunt that can have a first flow that can be modified to a second flow by modifying the shunt, such as by cutting the shunt. Additionally, one or more dissolvable portions can be present to provide an initial flow restriction and subsequent increase in flow over time.

Claims

1. A shunt for draining fluid from an anterior chamber of an eye, the shunt comprising:

a main section having an inlet, an outlet, and a wall defining a lumen with a first cross-sectional area and being configured to direct the fluid from the anterior chamber through the inlet toward the outlet such that, when positioned in the eye, fluid is released through the outlet at a location having lower pressure than the anterior chamber;

a first detachable flow restriction section, positioned at the outlet, in fluid communication with the main section, the first detachable flow restriction section having a second cross-sectional area that is less that the first cross-sectional area;

a second, permanent, detachable flow restriction section, positioned at the inlet, in fluid communication with the main section, the second detachable flow restriction section having a third cross-sectional area that is less that the first cross-sectional area, the second detachable flow restriction section being severable to adjust a flow of fluid through the shunt; and

a pharmaceutical or biological agent deliverable to the eye.

2. The shunt of claim 1, wherein the main section is formed from a separate material from the first and second detachable flow restriction sections.

3. The shunt of claim 1, wherein the first detachable flow restriction section is dissolvable.

4. The shunt of claim 1, wherein the first detachable flow restriction section comprises first and second portions that are concentrically layered within the lumen.

5. The shunt of claim 1, wherein the first detachable flow restriction section comprises first and second portions, the first portion having a first dissolution rate, and the second portion having a second dissolution rate different from the first dissolution rate.

6. The shunt of claim 1, wherein the first or second detachable flow restriction section comprises the pharmaceutical or biological agent.

7. The shunt of claim 1, wherein the pharmaceutical or biological agent comprises a coating on an exterior surface of the main section.

8. The shunt of claim 1, wherein the pharmaceutical or biological agent comprises a coating on an interior surface of the main section.

9. The shunt of claim 1, wherein a portion of the shunt is impregnated with the pharmaceutical or biological agent.

10. The shunt of claim 1, wherein the pharmaceutical or biological agent comprises a time-release pharmaceutical or biological agent.

11. The shunt of claim 1, wherein the second, permanent, detachable flow restriction section comprises a cross-linked gelatin.

12. The shunt of claim 11, wherein the second, permanent, detachable flow restriction section comprises a cross-linked gelatin subjected to a crosslinker.