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Dry powder compositions with magnesium stearate

  • US 10,195,147 B1
  • Filed: 09/26/2017
  • Issued: 02/05/2019
  • Est. Priority Date: 09/22/2017
  • Status: Active Grant
First Claim
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1. A dry powder composition for delivery to a subject by inhalation, comprising dry particles comprising acetylsalicylic acid (ASA), or a pharmaceutically acceptable salt thereof, co-micronized with magnesium stearate, wherein the magnesium stearate is in an amount of about 0.05% (w/w) to about 0.5% (w/w) of the dry powder composition, wherein ASA stability maintains 95% or above after exposure to a condition selected from the group consisting of 15-20°

  • C./35-45% RH, 20°

    C./40% RH, 30°

    C./60% RH, 40°

    C./75% RH, and 50°

    C./75% RH, for two weeks, four weeks, 30 days, a month, six weeks, eight weeks, or 12 months.

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