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Activin-ActRII antagonists and uses for treating bone and other disorders

  • US 10,195,249 B2
  • Filed: 11/01/2013
  • Issued: 02/05/2019
  • Est. Priority Date: 11/02/2012
  • Status: Active Grant
First Claim
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1. A method for treating vascular calcification in a subject in need thereof, wherein the method comprises administering a therapeutically effective amount of an ActRIIA inhibitor to the subject, wherein the ActRIIA inhibitor is a polypeptide comprising an amino acid sequence selected from the group consisting of:

  • a. 90% identical to SEQ ID NO;

    2;

    b. 95% identical to SEQ ID NO;

    2;

    c. 98% identical to SEQ ID NO;

    2;

    d. SEQ ID NO;

    2;

    e. 90% identical to SEQ ID NO;

    3;

    f. 95% identical to SEQ ID NO;

    3;

    g. 98% identical to SEQ ID NO;

    3;

    h. SEQ ID NO;

    3;

    i. 90% identical to SEQ ID NO;

    6;

    j. 95% identical to SEQ ID NO;

    6;

    k. 98% identical to SEQ ID NO;

    6;

    l. SEQ ID NO;

    6;

    m. 90% identical to SEQ ID NO;

    7;

    n. 95% identical to SEQ ID NO;

    7;

    o. 98% identical to SEQ ID NO;

    7;

    p. SEQ ID NO;

    7;

    q. 90% identical to SEQ ID NO;

    12;

    r. 95% identical to SEQ ID NO;

    12;

    s. 98% identical to SEQ ID NO;

    12; and

    t. SEQ ID NO;

    12.

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