Resettable drug delivery device

• US 10,195,354 B2
• Filed: 03/09/2015
• Issued: 02/05/2019
• Est. Priority Date: 06/01/2009
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Jones, Christopher
• Primary Examiner(s): Stigell, Theodore
• Application Number:
  US14/641,541
• Publication Number:
  US 20150190583A1
• Time in Patent Office: 1,429 Days
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31543 piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button

Abstract

A resettable dosing mechanism comprises a dose button and a dial grip operatively coupled to the dose button. A spindle acts on a bung of a cartridge and a driver is operatively coupled between the dose button and the spindle. During an injection of the dose, the dose button moves in an axial direction to cause the spindle to administer the dose. During resetting of the dose setting mechanism, the spindle is retracted back into the dose setting mechanism. An advantageous resetting mechanism is described.

Claims

1. A resettable dosing mechanism, wherein said dosing mechanism is removably connectable to a cartridge holder, said dosing mechanism comprising:

a dose button;

a dial grip operatively coupled to said dose button, said dial grip rotatable to set a dose;

a spindle for acting on a bung of a cartridge; and

a driver operatively coupled to said dose button and said spindle, wherein during an injection of said dose, said dose button moves in an axial direction to cause said spindle to administer said dose, and

a resetting mechanism for resetting of said dosing mechanism by retracting back said spindle into said dosing mechanism, wherein during said injection of said dose, said spindle rotates while advancing in said distal direction and wherein said dial grip must be moved axially in order to activate said resetting mechanism, wherein said dial grip must be pulled in a proximal direction in order to activate said resetting mechanism in order to retract said spindle back into said dosing mechanism.

2. The mechanism of claim 1 wherein said dial grip must be rotated to a predefined position before said resetting mechanism can be activated.

3. The mechanism of claim 2 wherein said dial grip must be rotated to an initial starting position, before said resetting mechanism can be activated by pulling said dial grip in said proximal direction to retract said spindle back into said dosing mechanism.

4. A resettable drug delivery device comprising:

a resettable dosing mechanism, wherein said dosing mechanism is removably connectable to a cartridge holder, said dosing mechanism comprising;

a dose button;

a dial grip operatively coupled to said dose button, said dial grip rotatable to set a dose;

a spindle for acting on a bung of a cartridge; and

a driver operatively coupled to said dose button and said spindle, wherein during an injection of said dose, said dose button moves in an axial direction to cause said spindle to administer said dose,

a resetting mechanism for resetting of said dosing mechanism by retracting back said spindle into said dosing mechanism, wherein during said injection of said dose, said spindle rotates while advancing in said distal direction and wherein said dial grip must be moved axially in order to activate said resetting mechanism,

an inner housing having at least one helical groove;

a dose dial sleeve rotationally engaged with the at least one helical groove of said inner housing;

a first clutch provided between said dose dial sleeve and said driver; and

a second clutch between said inner housing and said driver;

wherein when a dose is set with said dosing mechanism, said first clutch engages said dose dial sleeve and said driver to rotate together relative to said inner housing;

wherein when the set dose is injected, said first clutch disengages said dose dial sleeve from said driver while said second clutch couples said driver to said inner housing, so that said dose dial sleeve rotates and said driver is prevented from rotating but moves axially against a spindle to expel said set dose; and

wherein when resetting said dosing mechanism, said first clutch decouples said driver from said dose dial sleeve and said second clutch decouples said driver from said inner housing, allowing said driver to be moved to a reset position.

5. The drug delivery device of claim 4 wherein said driver is moved in an axial direction in order to place said driver in said reset position.

6. The drug delivery device of claim 4 wherein said driver is moved in a proximal direction in order to place and rotate said driver in said reset condition.

7. The drug delivery device of claim 4 further comprising a cartridge holder coupled to said dosing mechanism, wherein the cartridge holder comprises a cartridge containing a medicament.

8. The drug delivery device of claim 4, wherein the inner housing comprises the helical groove along an outer surface.

9. The drug delivery device of claim 4 wherein said driver is operatively coupled to the dial grip, wherein said dial grip is rotatable to set said dose of medication.

10. The drug delivery device of claim 4 wherein said dose dial sleeve comprises a scale arrangement, said scale arrangement indicative of said dose is set with said dosing mechanism.