×

Multiple impact microprojection applicators and methods of use

  • US 10,195,409 B2
  • Filed: 03/10/2014
  • Issued: 02/05/2019
  • Est. Priority Date: 03/15/2013
  • Status: Active Grant
First Claim
Patent Images

1. A method of delivering a therapeutic agent to a subject, comprising:

  • applying to a skin site of a subject, an applicator comprising at least one plunger element, at least one microprojection retained on a distal surface of the plunger, and an actuator;

    actuating the actuator to convey an external force to the at least one plunger element such that an energy required for the at least one microprojection to penetrate the skin site is delivered in multiple, discrete quanta and/or impacts at the skin site;

    wherein, the multiple, discrete quanta and/or impacts are created by at leastthe plunger comprising multiple energy-mass systems, each system having a different time constant, wherein each of the energy-mass systems has a progressively higher time constant such that the plunger elements impact the skin site in a defined sequence.

View all claims
  • 10 Assignments
Timeline View
Assignment View
    ×
    ×