Method of determining an analyte concentration

• US 10,196,512 B2
• Filed: 12/16/2016
• Issued: 02/05/2019
• Est. Priority Date: 10/28/2004
• Status: Active Grant

• Current Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Original Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Inventors: Valint, Jr., Paul, Williamson, Doug H., Zhu, Boru
• Primary Examiner(s): Cabral, Robert S
• Application Number:
  US15/381,578
• Publication Number:
  US 20170145203A1
• Time in Patent Office: 781 Days
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: C08L 2203/02 for biomedical use
• CPC Class Codes: C08L 33/24 Homopolymers or copolymers of amides or imides
• CPC Class Codes: C08L 33/26 Homopolymers or copolymers of acrylamide or methacrylamide
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: G01N 27/4166 measuring a particular property of an electrolyte
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.

Claims

1. A method of determining an analyte concentration, the method comprising the acts of:

placing a hydrogel composition on skin, the hydrogel composition contacting the working electrode, the hydrogel composition comprising a first monomer, a second monomer, a cross-linking agent, and a solvent, the first monomer being selected from Formula I

2. The method of claim 1, wherein the ratio of the first monomer to the second monomer is from about 40:

60 to about 60;

40.

3. The method of claim 1, wherein the analyte is glucose.

4. The method of claim 1, wherein the sensor is an electrochemical sensor.

5. The method of claim 1, wherein the first monomer is N-vinyl pyrrolidone and the second monomer is a vinyl ester.

6. The method of claim 1, wherein the first monomer is N-vinyl pyrrolidone.

7. The method of claim 1, wherein the first monomer is N-vinyl caprolactam.

8. The method of claim 1, wherein the hydrogel composition has a thickness of from about 0.1 mil to about 100 mils.

9. The method of claim 8, wherein the hydrogel composition has a thickness of from about 1 mil to about 30 mils.

10. An electrochemical sensor system comprising:

an electrochemical sensor having at least a counter electrode and a working electrode; and

a hydrogel composition contacting the working electrode, the hydrogel composition comprising a first monomer, a second monomer, a cross-linking agent, and a solvent, the first monomer being selected from Formula I

11. The electrochemical sensor system of claim 10, wherein the ratio of the first monomer to the second monomer is from about 40:

60 to about 60;

40.

12. The electrochemical sensor system of claim 10, wherein the analyte is glucose.

13. The electrochemical sensor system of claim 10, wherein the first monomer is N-vinyl pyrrolidone and the second monomer is a vinyl ester.

14. The electrochemical sensor system of claim 10, wherein the first monomer is N-vinyl pyrrolidone.

15. The electrochemical sensor system of claim 10, wherein the first monomer is N-vinyl caprolactam.

16. The electrochemical sensor system of claim 10, further including a mechanical support to assist in providing mechanical strength to the hydrogel composition.

17. The electrochemical sensor system of claim 15, wherein the mechanical support is polymeric mesh, woven fabric, non-woven fabric, cellulose, or combinations thereof.

18. The electrochemical sensor system of claim 10, wherein the hydrogel composition has a thickness of from about 0.1 mil to about 100 mils.

19. The electrochemical sensor system of claim 17, wherein the hydrogel composition has a thickness of from about 1 mil to about 30 mils.