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Prostate cancer classification

  • US 10,196,697 B2
  • Filed: 12/12/2014
  • Issued: 02/05/2019
  • Est. Priority Date: 12/12/2013
  • Status: Active Grant
First Claim
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1. A method of treating prostate cancer in a subject in need thereof, comprising:

  • a) obtaining a prostate cancer sample of a tissue from a subject, wherein the tissue is already known to be a prostate cancer, wherein the prostate cancer sample comprises cancer cells and normal cells;

    b) measuring the expression level of p53 and DNA Damage-Regulated Protein 1 (PDRG1) in the cancer cells from the prostate cancer sample and in the normal cells from the same prostate cancer sample;

    c) comparing the expression levels of PDRG1 in the cancer cells to the normal cells;

    d) detecting a significant increase in expression of PDRG1 in the cancer cells relative to the normal cells;

    e) characterizing and/or prognosing the subject as having an increased likelihood of cancer recurrence and/or an increased likelihood of cancer metastasis; and

    f) administering a chemotherapeutic agent or radiotherapy to said subject of part (e), or carrying out prostate cancer removal surgery on said subject of part (e).

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