Automated diagnostic analyzers having vertically arranged carousels and related methods

• US 10,197,585 B2
• Filed: 07/25/2016
• Issued: 02/05/2019
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Abbott Laboratories Incorporated, Toshiba Medical Systems Corporation (Canon Inc.)
• Original Assignee: Abbott Laboratories Incorporated, Toshiba Medical Systems Corporation (Canon Inc.)
• Inventors: Ochranek, Brian L., Arnquist, David C., Oonuma, Takehiko, Tahara, Hirotoshi, Sato, Naoto
• Primary Examiner(s): Mui, Christine T
• Application Number:
  US15/218,833
• Publication Number:
  US 20160334430A1
• Time in Patent Office: 925 Days
• Field of Search: 422 63, 422 64, 422 65, 220200, 220253
• CPC Class Codes: G01N 2035/0444 for cuvettes or reaction vessels
• CPC Class Codes: G01N 2035/0455 Coaxial carousels
• CPC Class Codes: G01N 35/02 using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations G01N35/0098 and G01N35/0099 take precedence
• CPC Class Codes: G01N 35/025 having a carousel or turntable for reaction cells or cuvettes
• CPC Class Codes: G01N 35/04 Details of the conveyor system G01N35/021 - G01N35/028 take precedence
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/119163 with aspirator of claimed structure

Abstract

Example automated diagnostic analyzers and methods for using the same are disclosed herein. An example apparatus described herein includes a first carousel rotatably coupled to a base and having a first axis of rotation. The example apparatus includes a second carousel rotatably coupled to the base and vertically spaced over the first carousel such that at least a portion of the second carousel is disposed over the first carousel. In the example apparatus, the second carousel has a second axis of rotation and a plurality of vessels. The example apparatus also includes a pipetting mechanism offset from the second axis of rotation. The example pipetting mechanism is to access the first carousel and the second carousel.

Claims

1. An apparatus comprising:

a first carousel rotatably coupled to a base, the first carousel rotatable about a first axis of rotation;

a second carousel rotatably coupled to the base and vertically spaced from the first carousel such that at least a portion of the second carousel is disposed over the first carousel, the second carousel rotatable about a second axis of rotation; and

a first pipetting mechanism rotatable about a third axis of rotation, the third axis of rotation offset from the second axis of rotation, the third axis of rotation disposed within a circumference of the first carousel, the first pipetting mechanism to access the first carousel and the second carousel.

2. The apparatus of claim 1, wherein the second carousel has a smaller diameter than the first carousel.

3. The apparatus of claim 1, wherein, from a top plan view, the second carousel is disposed within the circumference of the first carousel.

4. The apparatus of claim 1 further including a second pipetting mechanism to access the first carousel and the second carousel.

5. The apparatus of claim 4, wherein the first carousel includes an outer annular array of containers and an inner annular array of containers concentric with the outer annular array of containers.

6. The apparatus of claim 5, wherein the outer annular array of containers include a first type of reagent and the inner annular array of containers include a second type of reagent different than the first type of reagent.

7. The apparatus of claim 5, wherein the first pipetting mechanism is to access the inner annular array of containers and the second pipetting mechanism is to access the outer annular array of containers.

8. The apparatus of claim 4, wherein the second pipetting mechanism is rotatable about a fourth axis of rotation, the fourth axis of rotation offset from the second axis of rotation.

9. The apparatus of claim 8, wherein the fourth axis of rotation is disposed within the circumference of the first carousel.

10. The apparatus of claim 8 further including a third pipetting mechanism rotatable about a fifth axis of rotation, the fifth axis of rotation disposed outside of the circumference of the first carousel.

11. The apparatus of claim 1, wherein the circumference is a first circumference and the third axis of rotation is disposed within a second circumference of the second carousel.

12. The apparatus of claim 1, wherein the second carousel includes an annular rack having a bore, wherein the first pipetting mechanism includes a base assembly extending through the bore, and wherein the third axis of rotation is defined by the base assembly.

13. The apparatus of claim 12, wherein a pipette of the first pipetting mechanism is movable through the bore of the second carousel to access the first carousel.

14. The apparatus of claim 13 further including a second pipetting mechanism rotatable about a fourth axis of rotation, the fourth axis of rotation disposed within the circumference of the first carousel and outside of the circumference of the second carousel.

15. The apparatus of claim 14 further including a third pipetting mechanism rotatable about a fifth axis of rotation, the fifth axis of rotation disposed outside of the circumference of the first carousel and outside of the circumference of the second carousel.

16. The apparatus of claim 15, wherein the first pipetting mechanism and the second pipetting mechanism are to access the second carousel.

17. The apparatus of claim 9, wherein the fourth axis of rotation is further disposed within a circumference of the second carousel.

18. The apparatus of claim 1, wherein the first carousel includes a plurality of reagent containers and the second carousel includes a plurality of reaction vessels, the first pipetting mechanism is to aspirate a reagent from one of the reagent containers on the first carousel and dispense the reagent into one of the reaction vessels on the second carousel.

19. The apparatus of claim 18, further including a second pipetting mechanism rotatable about a fourth axis of rotation disposed outside of the circumference of the first carousel and outside of a circumference of the second carousel, the second pipetting mechanism to aspirate a sample and dispense the sample into the reaction vessel on the second carousel.

20. The apparatus of claim 19, wherein the second pipetting mechanism is to aspirate the sample from a sample container disposed outside of the circumference of the first carousel and the circumference of the second carousel.

21. The apparatus of claim 1, further including a computer processor including software programmed to control the first pipetting mechanism to aspirate a liquid from a container on the first carousel and dispense the liquid into a container on the second carousel.