Devices and methods for removal of acute blockages from blood vessels

• US 10,201,360 B2
• Filed: 03/12/2014
• Issued: 02/12/2019
• Est. Priority Date: 03/14/2013
• Status: Active Grant

• Current Assignee: Neuravi Limited (Johnson & Johnson)
• Original Assignee: Neuravi Limited (Johnson & Johnson)
• Inventors: Vale, David, Brady, Eamon, Gilvarry, Michael, Hardiman, David, Casey, Brendan
• Primary Examiner(s): Stransky, Katrina
• Assistant Examiner(s): Rwego, Kankindi
• Application Number:
  US14/207,069
• Publication Number:
  US 20140371780A1
• Time in Patent Office: 1,798 Days
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/00942 hydrophilic
• CPC Class Codes: A61B 2017/00951 adhesive
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/2212 having a closed distal end, e.g. a loop
• CPC Class Codes: A61B 2017/2217 single wire changing shape to a gripping configuration
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: B05D 1/322 Removable films used as masks
• CPC Class Codes: B05D 3/12 by mechanical means

Abstract

A clot retrieval device may include an elongate shaft and an expandable section. The expandable section may include a framework of interconnected strut elements. The connection region between adjacent strut elements may include crown elements. Additionally, the framework may be formed from a substrate material and at least a portion of a plurality of said strut elements may be coated with a coating material. Further, at least a portion of a plurality of said crown elements may not be coated with said coating material.

Claims

1. A clot retrieval device, comprising:

a shaft with a proximal end and a distal end; and

an expandable network of struts having a proximal end coupled to and extending distally of a distal-most end of the shaft, the expandable network including;

a plurality of strut members that form an outer expandable body and an inner expandable body, each body being joined at the proximal end coupled to the distal-most end of the shaft, wherein the inner and outer expandable bodies are distally pushable by the shaft from a collapsed delivery configuration to an expanded deployed configuration,

at least a portion of some of said plurality of strut members including;

a first coating of radiopaque material defining a plurality of discrete micro-columns, wherein each micro-column includes a length extending between a first end coupled to one of the plurality of strut members and a second free end, opposite the first end, and

wherein the second free end is capable of moving further apart when a convex bend is applied to the respective strut member during use;

wherein the length of each micro-column of the plurality of discrete micro-columns is longer than a width of each micro-column of the plurality of discrete micro-columns; and

a second coating; and

a plurality of connections, each connection being between adjacent strut members.

2. The clot retrieval device of claim 1, wherein the expandable network is formed of Nitinol.

3. The clot retrieval device of claim 1, wherein the radiopaque material includes one of Barium Sulphate, Bismuth SubCarbonate, Barium OxyChloride, Gold, Tungsten, Platinum, or Tantalum.

4. The clot retrieval device of claim 1, wherein the second coating includes one of a polymer material, a hydrophilic material, or a hydrogel material.

5. The clot retrieval device of claim 1, wherein in the expanded deployed configuration, an outer diameter of the outer expandable body is greater than an outer diameter of the inner expandable body.

6. The clot retrieval device of claim 1, wherein in the shaft is separate from the expandable network of struts.

7. The clot retrieval device of claim 1, wherein the plurality of connections form at least one crown;

and

wherein each micro-column of the plurality of discrete micro-columns has minimal connectivity between each.

8. The clot retrieval device of claim 7, wherein the at least one crown is at least partially coated with the first coating of radiopaque material.

9. The clot retrieval device of claim 1, wherein in a first unstressed configuration, the second free end of a first micro-column is spaced a first distance from the second free end of an adjacent second micro-column.

10. The clot retrieval device of claim 9, wherein in a second stressed configuration, the second free end of the first micro-column is spaced a second distance from the second free end of the adjacent second micro-column.

11. The clot retrieval device of claim 10, wherein the second distance is greater than the first distance.

12. A clot retrieval device, comprising:

a shaft; and

an expandable network of struts coupled to a distal end of the shaft, the expandable network including;

an outer expandable body, an inner expandable body, and a pair of side wall surfaces, each body comprising a plurality of strut members, wherein a distal end of the shaft is connected to a proximal end of the inner and outer expandable bodies, wherein the inner and outer expandable bodies are pushable into a clot by the shaft from a collapsed delivery configuration to an expanded deployed configuration; and

a plurality of connections, each connection being between adjacent strut members, at least one of the surfaces of the expandable network having;

a first coating of radiopaque material defining a plurality of discrete micro-columns, wherein each micro-column includes a length extending between a first end coupled to one of the plurality of strut members and a second free end, opposite the first end, and

wherein the second free end is capable of moving further apart when a convex bend is applied to the respective strut member without a high strain being induced in the first coating;

wherein the length of each micro-column of the plurality of discrete micro-columns is longer than a width of each micro-column of the plurality of discrete micro-columns; and

a second coating including one of a polymer material, a hydrophilic material, or a hydrogel material.

13. The clot retrieval device of claim 12, wherein the first coating is located on a side wall surface of each of the plurality of strut members.

14. The clot retrieval device of claim 12, wherein the expandable network is formed of Nitinol.

15. The clot retrieval device of claim 12, wherein the radiopaque material includes one of Barium Sulphate, Bismuth SubCarbonate, Barium OxyChloride, Gold, Tungsten, Platinum, or Tantalum.

16. The clot retrieval device of claim 12, wherein in a first unstressed configuration, the second free end of a first micro-column is spaced a first distance from the second free end of an adjacent second micro-column.

17. The clot retrieval device of claim 16, wherein in a second stressed configuration, the second free end of the first micro-column is spaced a second distance from the second free end of the adjacent second micro-column.

18. A clot retrieval device, comprising:

a shaft;

an inner expandable body distally movable by the shaft from a collapsed delivery configuration to an expanded deployed configuration, wherein a distal end of the shaft is connected to a proximal end of the inner expandable body; and

an outer body at least partially overlying the inner expandable body, wherein the distal end of the shaft is connected to a proximal end of the outer body, the shaft also being capable of distally moving the outer body, the outer body including a plurality of struts and connectors connecting the struts, at least a portion of some of said plurality of struts including;

a first coating of radiopaque material defining a plurality of discrete micro-columns wherein each micro-column includes a length extending between a first end coupled to one of the plurality of strut members and a second free end, opposite the first end, the second free end being capable of moving further apart without a high strain being induced in the first coating; and

a second coating, wherein the second coating is disposed on the first coating over and between at least some of the plurality of discrete micro-columns.

19. The clot retrieval device of claim 18, wherein the second coating includes one of a polymer material, a hydrophilic material, or a hydrogel material.

20. The clot retrieval device of claim 18, wherein each micro-column includes a first end coupled to one of the plurality of struts and a second free end, opposite the first end, wherein in a first unstressed configuration, the second free end of a first micro-column is spaced a first distance from the second free end of an adjacent second micro-column, and wherein in a second stressed configuration, the second free end of the first micro-column is spaced a second distance, greater than the first distance, from the second free end of the adjacent second micro-column.