Cardiovascular prostheses

• US 10,201,636 B2
• Filed: 12/21/2016
• Issued: 02/12/2019
• Est. Priority Date: 12/20/2010
• Status: Active Grant

• Current Assignee: Elutia Med LLC
• Original Assignee: Cormatrix Cardiovascular, Inc.
• Inventors: Matheny, Robert G
• Primary Examiner(s): Zhang, Yanzhi
• Application Number:
  US15/386,750
• Publication Number:
  US 20170100522A1
• Time in Patent Office: 783 Days
• Field of Search: 424400
• CPC Class Codes: A61F 2/0095 Packages or dispensers for prostheses or other implants for intraocular lenses A61F2/1691; for dental surgery A61C19/02
• CPC Class Codes: A61F 2/2445 Annuloplasty rings in direct contact with the valve annulus
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2430/20 for reconstruction of the heart, e.g. heart valves
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: C08L 67/02 Polyesters derived from dicarboxylic acids and dihydroxy compounds C08L67/06 takes precedence

Abstract

Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.

Claims

1. A cardiovascular prosthesis consisting of:

a sheet member consisting of an antibiotic augmented ECM-mimicking composition, said antibiotic augmented ECM-mimicking composition consisting of poly(glycerol sebacate) (PGS), vancomycin and gentamicin,

said sheet member, when disposed proximate damaged biological tissue, being adapted to induce anti-microbial and anti-biofilm activity and, thereby, enhanced inflammation modulation.

2. A cardiovascular prosthesis consisting of:

a sheet member consisting of an antibiotic augmented ECM-mimicking composition, said antibiotic augmented ECM-mimicking composition consisting of poly(glycerol sebacate) (PGS), vancomycin, gentamicin and a basic fibroblast growth factor (bFGF).