Methods for providing sensor site rotation feedback and related infusion devices and systems

• US 10,201,657 B2
• Filed: 08/18/2016
• Issued: 02/12/2019
• Est. Priority Date: 08/21/2015
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Parikh, Neha J., Gottlieb, Rebecca K., Grosman, Benyamin, Roy, Anirban, Wu, Di
• Primary Examiner(s): Osinkski, Bradley J
• Application Number:
  US15/240,720
• Publication Number:
  US 20170049962A1
• Time in Patent Office: 908 Days
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/684 Indicating the position of the sensor on the body
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: A61B 5/748 Selection of a region of interest, e.g. using a graphics tablet
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/16877 Adjusting flow; Devices for setting a flow rate
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device to deliver fluid to a body of a user involves identifying a current site location on the body of the user associated with a sensing arrangement providing sensed measurements of a physiological condition in the body of the user at the current site location, determining one or more performance metrics associated with the current site location corresponding to operation of the infusion device to deliver the fluid in response to the sensed measurements, and providing sensor site feedback in a manner that is influenced by the one or more performance metrics. In one or more embodiments, the sensor site feedback includes recommended sensor site locations for rotation or replacement of the sensing arrangement determined based on historical data associated with the user for different sensor site locations.

Claims

1. A method of operating an infusion device to deliver a fluid influencing a physiological condition to a body of a user, the method comprising:

obtaining one or more reference measurements of the physiological condition in the body of the user;

determining a lag associated with a sensing arrangement providing sensed measurements of the physiological condition in the body of the user based on a relationship between the one or more reference measurements and one or more of the sensed measurements;

identifying a current site location on the body of the user associated with the sensing arrangement from among a plurality of site locations based on the lag;

determining one or more performance metrics associated with the current site location corresponding to operation of the infusion device to deliver the fluid in response to the sensed measurements; and

providing sensor site feedback in a manner that is influenced by the one or more performance metrics.

2. The method of claim 1, the current site location comprising one of the plurality of site locations, the method further comprising:

maintaining an association between the lag and the one of the plurality of site locations; and

thereafter;

obtaining one or more subsequent reference measurements of the physiological condition in the body of the user;

determining a second lag associated with a second sensing arrangement providing subsequent sensed measurements of the physiological condition in the body of the user based on a relationship between the one or more subsequent reference measurements and the subsequent sensed measurements; and

identifying a site location associated with the second sensing arrangement as the one of the plurality of site locations based on the second lag, the lag, and the association between the lag and the one of the plurality of site locations.

3. The method of claim 1, wherein determining the lag comprises:

generating a plurality of time shifted representations of the one or more of the sensed measurements having different amounts of time shifting;

determining a correlation metric for each of the plurality of time shifted representations based on the one or more reference measurements; and

identifying the lag as an amount of time shifting associated with a respective one of the plurality of time shifted representations having a highest value for the correlation metric.

4. The method of claim 1, further comprising autonomously operating the infusion device to regulate the physiological condition based on the sensed measurements and a target value for the physiological condition in the body of the user, wherein the one or more performance metrics are determined based on the sensed measurements during the autonomous operation.

5. The method of claim 1, wherein providing the sensor site feedback comprises generating a graphical representation of one or more recommended site locations different from the current site location.

6. The method of claim 5, further comprising determining the one or more recommended site locations based on historical data associated with each of a plurality of site locations.

7. The method of claim 6, further comprising determining the one or more recommended site locations based on site recommendation criteria associated with the user.

8. The method of claim 1, further comprising:

determining a calibration factor associated with the sensed measurements based on the one or more reference measurements in a manner that is influenced by the lag; and

autonomously operating the infusion device to regulate the physiological condition based on the sensed measurements, the calibration factor, and a target value for the physiological condition in the body of the user.

9. The method of claim 1, further comprising:

adjusting one or more control parameters in a manner that is influenced by the lag; and

autonomously operating the infusion device to regulate the physiological condition based on the sensed measurements, the one or more control parameters, and a target value for the physiological condition in the body of the user.

10. The method of claim 1, further comprising:

receiving, by a server coupled to a network, the sensed measurements from one of the sensing arrangement and the infusion device via the network; and

determining, by the server, one or more recommended site locations based on historical data associated with the user stored in a database, wherein;

identifying the current site location comprises the server identifying the current site location based on the sensed measurements and the historical data associated with the user stored in the database; and

providing the sensor site feedback comprises the server generating, on a client device coupled to the server via the network, a graphical indication of the one or more recommended site locations in response to the one or more performance metrics failing to satisfy a threshold.

11. The method of claim 1, further comprising receiving, by a server coupled to a network, the sensed measurements from one of the sensing arrangement and the infusion device via the network, wherein:

identifying the current site location comprises the server identifying the current site location based on the sensed measurements and historical data associated with the user stored in a database; and

providing the sensor site feedback comprises the server generating, on a client device coupled to the server via the network, a graphical representation of the one or more performance metrics associated with the current site location.

12. A computer-readable medium having computer-executable instructions stored thereon that, when executed by a processing system of an electronic device, cause the processing system to perform the method of claim 1.

13. An infusion system comprising:

a sensing arrangement to obtain sensed measurement values for a physiological condition from a body of a user;

an infusion device including;

an actuation arrangement operable to deliver fluid influencing the physiological condition to the body of the user;

a user interface; and

a control system coupled to the actuation arrangement and the sensing arrangement to;

autonomously operate the actuation arrangement to deliver the fluid based on the sensed measurement values;

obtain one or more reference measurements of the physiological condition in the body of the user;

determine a lag associated with the sensing arrangement based on a relationship between the one or more reference measurements and one or more of the sensed measurement values;

identify a current site location on the body of the user associated with the sensing arrangement from among a plurality of site locations based on the lag;

determine one or more performance metrics associated with the current site location based on the sensed measurement values; and

provide sensor site feedback via the user interface in a manner that is influenced by the one or more performance metrics.

14. The infusion system of claim 13, wherein the control system updates a calibration factor associated with the sensed measurement values in a manner that is influenced by the lag.

15. The infusion system of claim 13, wherein the sensor site feedback comprises generating a graphical representation of one or more recommended site locations different from the current site location.

16. A system comprising:

a sensing arrangement to obtain sensed measurement values for a physiological condition from a body of a user;

an infusion device communicatively coupled to the sensing arrangement and including an actuation arrangement operable to deliver fluid influencing the physiological condition to the body of the user in response to the sensed measurement values;

a database to maintain historical data associated with the user; and

a server coupled to the database and a network to;

obtain one or more reference measurements of the physiological condition in the body of the user;

determine a lag associated with the sensing arrangement based on a relationship between the one or more reference measurements and one or more of the sensed measurement values;

identify a current site location on the body of the user associated with the sensing arrangement from among a plurality of site locations based on the lag and one or more of the sensed measurement values and the historical data;

determine one or more performance metrics associated with the current site location based on the sensed measurement values associated with autonomous operation of the infusion device to deliver the fluid; and

provide site rotation feedback in a manner that is influenced by the one or more performance metrics and the historical data.

17. The system of claim 16, wherein the site rotation feedback comprises a graphical representation of one or more recommended site locations different from the current site location presented on a client device coupled to the server via the network in response to the one or more performance metrics failing to satisfy a threshold, wherein the server determines the one or more recommended site locations based on the historical data.

18. The system of claim 16, the historical data including sensor lags associated with respective ones of a plurality of site locations, wherein the server obtains one or more reference measurements of the physiological condition in the body of the user, determines a current lag associated with the sensing arrangement based on a relationship between the one or more reference measurements and the one or more of the sensed measurement values, and identifies the current site location as one of the plurality of site locations based on a relationship between the current lag and the sensor lags.