Article comprising a microneedle

• US 10,201,691 B2
• Filed: 07/10/2014
• Issued: 02/12/2019
• Est. Priority Date: 07/16/2013
• Status: Active Grant

• Current Assignee: Kindeva Drug Delivery L.P.
• Original Assignee: 3M Innovative Properties Company (3M Company)
• Inventors: Berry, Dennis G., Martinson, Paul A., Ng, Chin-Yee, Simmers, Ryan Patrick
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): Fredrickson, Courtney
• Application Number:
  US14/904,998
• Publication Number:
  US 20160151616A1
• Time in Patent Office: 1,678 Days
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 having a lumen
• CPC Class Codes: A61M 2037/0061 Methods for using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

An article 100 comprising at least one microneedle 160 is provided. The article comprises a first side 112 and a second side 114 opposite the first side. The first side comprises a central cavity portion 120 and a platform portion 130, with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle 160 comprises a body comprising an outer surface 163; a base segment 166 having a base and a first shape; a tip segment 168 having a tip 164 and a second shape, wherein the second shape is distinct from the first shape; a transition plane 167 that delineates the base segment and the tip segment; and a central axis.

Claims

1. An article, comprising:

a first side comprising a central cavity portion and a platform portion that projects from the first side and that is not coplanar with the central cavity portion;

a second side opposite the first side; and

at least three hollow microneedles extending from the platform portion in a first direction;

wherein the platform portion substantially surrounds the central cavity portion;

wherein the platform portion comprises an inner perimeter proximate the central cavity portion and an outer perimeter distal the central cavity portion;

wherein the at least three hollow microneedles each comprise a body that comprises;

an outer surface;

a base segment having a base and a first shape that is defined by a first section of the outer surface;

a tip segment having a tip and a second shape that is defined by a second section of the outer surface, wherein the second shape is distinct from the first shape;

a transition plane that delineates the base segment and the tip segment; and

a central axis;

wherein a first angle, defined by the central axis of each of the at least three hollow microneedles and a shortest line extending from the outer perimeter of the platform and through the transition plane of the microneedle, is less than about 50°

.

2. The article of claim 1, wherein a second angle, defined by the central axis and a shortest line extending from the inner perimeter and through the transition plane, is less than about 50°

.

3. The article of claim 1, wherein the transition plane is disposed about 500 μ

m to about 800 μ

m away from the platform portion when measured along the central axis.

4. The article of claim 1, wherein the first side further comprises a microneedle-free peripheral portion extending laterally from at least a part of the outer perimeter of the platform portion, wherein the peripheral portion is canted away from the platform portion in a second direction opposite the first direction.

5. The article of claim 4;

wherein the article further comprises a side wall portion that extends from the platform portion or, if present, the peripheral portion;

wherein the sidewall portion extends substantially opposite the first direction.

6. The article of claim 1, wherein the central cavity portion is a closed cavity portion.

7. The article of claim 1, wherein the central cavity portion is a through-hole extending from the first side through the second side.

8. The article of claim 1, wherein the platform is circinate.

9. The article of claim 1, wherein the at least three hollow microneedles are disposed in a circinate arrangement.

10. The article of claim 1, wherein a unitary body comprises the platform portion, the peripheral portion, and the central cavity portion.

11. The article of claim 1, wherein at least one microneedle of the at least three hollow microneedles comprises:

a base;

an elongated body having a central axis and a body diameter; and

wherein

the tip portion of the at least one microneedle further comprises

a first bevel face oriented diagonally with respect to the central axis and extending through at least 75% of the body diameter, a second bevel face oriented substantially perpendicular to the central axis and intersecting the first bevel face, a bevel opening defined by a first edge of the first bevel face and a second edge of the second bevel face; and

wherein the at least one microneedle further comprises a hollow channel that extends axially into the body from the bevel opening.

12. The article of claim 1, wherein at least one microneedle of the at least three hollow microneedles comprises:

an elongated body having a central axis; and

further wherein

the tip portion of the at least one microneedle further comprises

a beveled surface, and a bevel opening in the beveled surface; and

wherein the at least one microneedle further comprises

a first channel that extends axially from the bevel opening through at least a portion of the elongated body, wherein the first channel has a first wall that is substantially aligned with the central axis; and

a second channel that extends radially from the first channel to the bevel opening, wherein the second channel has a second wall that is oriented substantially orthogonal to the central axis;

wherein the first channel and second channel merge to form the bevel opening.

13. The article of claim 1, wherein at least one microneedle of the at least three microneedles comprises a hollow channel extending through the article from a first opening proximate the tip to a second opening in the second side of the article.

14. The article of claim 1, wherein the article is capable of extracting fluid from a body.

15. The article of claim 1, wherein the article is capable of injecting fluid into a body.

16. The article of claim 15, wherein the article is operatively coupled to an actuator.