Systems and methods of improving an inflammatory disorder
First Claim
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1. A method of improving an inflammatory disorder in a subject suffering therefrom comprising:
- positioning a therapy delivery device in communication with a neural target site, comprising at least a part of the enteric nervous system, that contributes to immune activity of the subject;
sensing, by at least one of an electrical sensor and a biological sensor, at least one physiological parameter of immune activity of the enteric nervous system that is indicative of an inflammatory disorder of the subject, wherein the at least one of the electrical sensor and biological sensor is disposed at an enteric plexus or ganglion;
delivering, by the therapy delivery device, a therapy signal to the neural target site, wherein delivery parameters of the therapy signal are selected based on the sensed at least one physiological parameter to modulate an immune response of the subject to treat the subject'"'"'s inflammatory disorder.
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Abstract
Methods for improving an inflammatory disorder in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. The therapy delivery device is activated to deliver a therapy signal to the neural target site to improve the subject'"'"'s inflammatory disorder.
32 Citations
19 Claims
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1. A method of improving an inflammatory disorder in a subject suffering therefrom comprising:
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positioning a therapy delivery device in communication with a neural target site, comprising at least a part of the enteric nervous system, that contributes to immune activity of the subject; sensing, by at least one of an electrical sensor and a biological sensor, at least one physiological parameter of immune activity of the enteric nervous system that is indicative of an inflammatory disorder of the subject, wherein the at least one of the electrical sensor and biological sensor is disposed at an enteric plexus or ganglion; delivering, by the therapy delivery device, a therapy signal to the neural target site, wherein delivery parameters of the therapy signal are selected based on the sensed at least one physiological parameter to modulate an immune response of the subject to treat the subject'"'"'s inflammatory disorder. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of improving an inflammatory disorder in a subject comprising:
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sensing, by at least one of an electrical sensor and biological sensor, the level of at least one physiological parameter that is indicative of immune activity of the enteric nervous system of the subject, wherein the at least one of the electrical sensor and biological sensor is disposed at an enteric plexus or ganglion; predicting dysfunction of the subject'"'"'s immune system by comparing the determined level of the at least one physiological parameter with a control value and determining, based on the comparison, that the level of the at least one physiological parameter is indicative of an inflammatory disorder of the subject; placing a therapy delivery device into communication with a neural target site, comprising at least a part of the enteric nervous system, that contributes to immune activity of the subject; and delivering, by the therapy delivery device, a therapy signal to the neural target site, wherein delivery parameters of the therapy signal are selected based on the sensed at least one physiological parameter to modulate an immune response of the subject to treat the subject'"'"'s inflammatory disorder.
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Specification