Plasmonic assisted systems and methods for interior energy-activation from an exterior source

• US 10,201,796 B2
• Filed: 02/27/2017
• Issued: 02/12/2019
• Est. Priority Date: 04/08/2007
• Status: Active Grant

• Current Assignee: Duke University, Immunolight, LLC
• Original Assignee: Duke University, Immunolight, LLC
• Inventors: Bourke, Jr., Frederic Avery, Vo-Dinh, Tuan
• Primary Examiner(s): McClendon, Sanza L.
• Application Number:
  US15/443,656
• Publication Number:
  US 20170173350A1
• Time in Patent Office: 715 Days
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Abstract

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

Claims

1. A method for producing a change in a medium, comprising:

(1) placing inside the medium an activatable agent,

(2) placing inside the medium a plasmonics agent and a photon emitter which is capable of emitting therefrom at least one of ultraviolet and visible light into the medium to be treated, wherein said photon emitter comprises a member selected from the group consisting of an up converter and a light needle emitting said at least one of ultraviolet and visible light;

(3) emitting from said photon emitter said at least one of ultraviolet and visible light at one or more positions inside the medium to be treated, wherein the plasmonics agent enhances the at least one of ultraviolet and visible light emitted from said photon emitter; and

(4) inducing from the light emitted into the medium a photoreactive change inside the medium.

2. The method of claim 1, wherein said activatable agent is capable of producing a pharmacological, cellular, chemical, electrical, or mechanical effect in a medium.

3. The method of claim 1, wherein said photon emitter comprises an up converter excited by an infrared source.

4. The method of claim 1, wherein said photon emitter comprises a plasmonics agent for enhancing an intensity of the light emitted into the medium.

5. The method of claim 1, wherein said photon emitter comprises a light needle emitting said at least one of ultraviolet and visible light.

6. The method of claim 1, wherein placing inside the medium a photoactivatable agent comprises placing the photoactivatable agent inside a patient.

7. The method of claim 1, wherein placing inside the medium a photoactivatable agent comprises placing a psoralen, a coumarin, or a derivative thereof inside a patient.

8. The method of claim 1,

wherein placing inside the medium a photoactivatable agent comprises placing a psoralen, a coumarin, or a derivative thereof inside a patient, and

wherein the psoralen, the coumarin, or the derivative thereof is activated by said at least one of ultraviolet and visible light.

9. The method of claim 1, wherein the photoreactive change inside the medium treats a disorder.

10. The method of claim 1, wherein the photoreactive change inside the medium treats a cancer or a tumor.

11. The method of claim 1, wherein the photoreactive change inside the medium treats an autoimmune deficiency.

12. The method of claim 1, wherein the photoreactive change inside the medium sterilizes the medium.

13. The method of claim 1, wherein the photoreactive change inside the medium cures resins in the medium.

14. The method of claim 1, wherein the activatable agent placed inside the medium is a photocatalyst, and the photoreactive change inside the medium treats a fluid medium by interaction of the at least one of ultraviolet and visible light with the photocatalyst.

15. The method of claim 1, wherein the photoreactive change inside the medium treats a cancer by inducing an autovaccine response in a patient.

16. The method of claim 1, wherein the photoreactive change inside the medium treats a cancer by inducing apoptosis of cancer cells in a patient.

17. A method for producing a change in a medium, comprising:

(1) placing inside the medium an activatable agent capable of producing a pharmacological or cellular change in the medium,

(2) placing inside the medium a plasmonics agent and a photon emitter which is capable of emitting therefrom at least one of ultraviolet and visible light into the medium to be treated, wherein said photon emitter comprises a member selected from the group consisting of a down converter excited by x-ray or a high energy source, an up converter excited by an infrared source and a light needle emitting said at least one of ultraviolet and visible light;

(3) emitting from said photon emitter said at least one of ultraviolet and visible light at one or more positions inside the medium to be treated, wherein the plasmonics agent enhances the at least one of ultraviolet and visible light emitted from said photon emitter; and

(4) inducing from the light emitted into the medium a photoreactive change inside the medium.

18. The method of claim 17, wherein said photon emitter comprises a down converter excited by x-ray or a high energy source.

19. The method of claim 17, wherein said photon emitter comprises an up converter excited by an infrared source.

20. The method of claim 17, wherein said photon emitter comprises a plasmonics agent for enhancing an intensity of the light emitted into the medium.

21. The method of claim 17, wherein said photon emitter comprises a light needle emitting said at least one of ultraviolet and visible light.

22. The method of claim 17, wherein placing inside the medium a photoactivatable agent comprises placing the photoactivatable agent inside a patient.

23. The method of claim 17, wherein placing inside the medium a photoactivatable agent comprises placing a psoralen, a coumarin, or a derivative thereof inside a patient.

24. The method of claim 17,

wherein placing inside the medium a photoactivatable agent comprises placing a psoralen, a coumarin, or a derivative thereof inside a patient, and

wherein the psoralen, the coumarin, or the derivative thereof is activated by said at least one of ultraviolet and visible light.

25. The method of claim 24, wherein said at least one of ultraviolet and visible light is emitted into the patient from at least one of a down converter excited by x-ray or a high energy source, an up converter excited by an infrared source, a light needle, and a fiber optic.

26. The method of claim 17, wherein the photoreactive change inside the medium treats a disorder.

27. The method of claim 17, wherein the photoreactive change inside the medium treats a cancer or a tumor.

28. The method of claim 17, wherein the photoreactive change inside the medium treats an autoimmune deficiency.

29. The method of claim 17, wherein the photoreactive change inside the medium sterilizes the medium.

30. The method of claim 17, wherein the photoreactive change inside the medium treats a cancer by inducing an autovaccine response in a patient.

31. The method of claim 17, wherein the photoreactive change inside the medium treats a cancer by inducing apoptosis of cancer cells in a patient.

32. A method for producing a change in a medium, comprising:

(1) placing inside the medium an activatable agent,

(2) placing inside the medium a plasmonics agent and a photon emitter which is capable of emitting therefrom at least one of ultraviolet and visible light into the medium to be treated;

(3) emitting from said photon emitter said at least one of ultraviolet and visible light at one or more positions inside the medium to be treated, wherein the plasmonics agent enhances the at least one of ultraviolet and visible light emitted from said photon emitter; and

(4) inducing from the light emitted into the medium a photoreactive change inside the medium, wherein the photoreactive change inside the medium treats a cancer by inducing an autovaccine response in a patient or by inducing apoptosis of cancer cells in a patient or both.

33. The method of claim 32, wherein said photon emitter comprises a down converter excited by x-ray or a high energy source.

34. The method of claim 32, wherein said photon emitter comprises an up converter excited by an infrared source.

35. The method of claim 32, wherein said photon emitter comprises a plasmonics agent for enhancing an intensity of the light emitted into the medium.

36. The method of claim 32, wherein said photon emitter comprises a light needle emitting said at least one of ultraviolet and visible light.

37. The method of claim 32, wherein said photon emitter comprises a fiber optic emitting said at least one of ultraviolet and visible light.

38. The method of claim 32, wherein placing inside the medium a photoactivatable agent comprises placing the photoactivatable agent inside a patient.

39. The method of claim 32, wherein placing inside the medium a photoactivatable agent comprises placing a psoralen, a coumarin, or a derivative thereof inside a patient.

40. The method of claim 32,

wherein placing inside the medium a photoactivatable agent comprises placing a psoralen, a coumarin, or a derivative thereof inside a patient, and

wherein the psoralen, the coumarin, or the derivative thereof is activated by said at least one of ultraviolet and visible light.

41. The method of claim 40, wherein said at least one of ultraviolet and visible light is emitted into the patient from at least one of a down converter excited by x-ray or a high energy source, an up converter excited by an infrared source, a light needle, and a fiber optic.

42. The method of claim 32, wherein the photoreactive change inside the medium treats a cancer or a tumor.

43. The method of claim 32, wherein the photoreactive change inside the medium treats a cancer by inducing an autovaccine response in a patient.

44. The method of claim 32, wherein the photoreactive change inside the medium treats a cancer by inducing apoptosis of cancer cells in a patient.