Electrochemical cell and method of making an electrochemical cell

• US 10,203,298 B2
• Filed: 05/02/2016
• Issued: 02/12/2019
• Est. Priority Date: 05/21/2004
• Status: Active Grant

• Current Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Original Assignee: Agamatrix Incorporated (AgaMatrix Holdings LLC d/b/a WaveForm Diabetes)
• Inventors: Harding, Ian, Iyengar, Sridhar G.
• Primary Examiner(s): Noguerola, Alexander S
• Application Number:
  US15/144,024
• Publication Number:
  US 20160245776A1
• Time in Patent Office: 1,016 Days
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: G01N 27/30 Electrodes, e.g. test electrodes; Half-cells G01N27/414 takes precedence
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 27/403 Cells and electrode assemblies
• CPC Class Codes: Y10T 156/1052 with cutting, punching, tearing or severing
• CPC Class Codes: Y10T 156/1062 Prior to assembly
• CPC Class Codes: Y10T 156/1074 Separate cutting of separate sheets or webs
• CPC Class Codes: Y10T 29/49002 Electrical device making
• CPC Class Codes: Y10T 29/49114 including adhesively bonding
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing

Abstract

Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.

Claims

1. A multi-cell test device, comprising:

a sample receiving end;

a connector end having a plurality of connectors; and

a plurality of adjacent electrochemical cells, comprising, in sequence;

(a) a common first substrate having a layer of conductive material applied to a first surface thereof;

(b) a common electrically-resistive middle layer; and

(c) a common second substrate having a layer of conductive material applied to a first surface thereof, the first surface of the first substrate and the first surface of the second substrate are adhered to the electrically resistive middle layer,

wherein a vent hole passes through the electrically resistive middle layer, and

wherein each electrochemical cell comprises;

a plurality of sample spaces passing through the electrically resistive middle layer and being bounded on opposing sides by a portion of the conductive material of the first and second substrates, the first substrate forming an unpatterned first electrode and being connected with the sample-receiving end of the device and the second substrate forming a second electrode and being connected with the sample-receiving end of the device, the sample spaces being divided by scribes line running from the sample receiving end to the connector end of the multi-cell test device.

2. A multi-cell test device according to claim 1, wherein the sample spaces are co-planar.

3. A multi-cell test device according to claim 1, wherein a first sample space is configured to be filled from a first edge of the multi-cell test device and a second sample space is configured to be filled from a second edge of the multi-cell test device.

4. A multi-cell test device according to claim 1, further comprising a reagent disposed within each sample space.

5. The multi-cell test device according to claim 4, wherein the reagent comprises an enzyme and a redox mediator.

6. The multi-cell test device according to claim 5, wherein the enzyme is glucose oxidase.

7. A multi-cell test device, comprising:

a plurality of coplanar electrochemical cells, comprising, in sequence;

(a) a common first substrate having a layer of conductive material applied to a first surface thereof;

(b) a common electrically-resistive middle layer; and

(c) a common second substrate having a layer of conductive material applied to a first surface thereof, the first surface of the first substrate and the first surface of the second substrate are adhered to the electrically resistive middle layer,

wherein a vent hole passes through the electrically resistive middle layer,

wherein each electrochemical cell comprises;

a sample receiving end,

a connector end having a plurality of connectors, and

a sample space passing through the electrically resistive middle layer and being bounded on opposite sides by a portion of the conductive material of the first and second substrates, the first substrate forming an unpatterned first electrode and being connected with the sample-receiving end of the device and the second substrate forming a second electrode and being connected with the sample-receiving end of the device; and

wherein each sample space is electrically isolated from other sample spaces by one or more cuts or scribe lines in the conductive material.

8. The multi-cell test device of claim 7, wherein the plurality of coplanar electrochemical cells are arranged in a linear fashion.

9. The multi-cell test device of claim 7, wherein the plurality of electrochemical test devices are arranged in parallel.

10. The multi-cell test device of claim 7, wherein the plurality of electrochemical cells are arranged in a nose-to-tail arrangement.

11. The multi-cell test device of claim 7, wherein the first connector has two contact pads, the second connector has at least one contact pad, and the at least one contact pad of the second connector is between the two contact pads of the first connector when viewed in the plane of the test strip.

12. The multi-cell test device of claim 7, wherein, except for the sample spaces, the facing conductive portions of the common first substrate and the common second substrate are separated by the common electrically resistive middle layer.

13. The multi-cell test device of claim 7, wherein the plurality of connectors extend from a common edge of each of the electrochemical test cells.

14. The multi-cell test device of claim 7, wherein the plurality of connectors extend from a common edge of the multi-cell test device.