Apparatus and associated methods for analyte detection

• US 10,203,303 B2
• Filed: 09/18/2014
• Issued: 02/12/2019
• Est. Priority Date: 10/09/2013
• Status: Active Grant

• Current Assignee: Nokia Technologies Oy (Nokia Corporation)
• Original Assignee: Nokia Technologies Oy (Nokia Corporation)
• Inventors: Astley, Michael, Wei, Di, Borini, Stefano, Kivioja, Jani
• Primary Examiner(s): Noguerola, Alexander S
• Application Number:
  US15/021,744
• Publication Number:
  US 20160223490A1
• Time in Patent Office: 1,608 Days
• CPC Class Codes: G01N 27/307 Disposable laminated or multilayered electrodes G01N27/3272 takes precedence
• CPC Class Codes: G01N 27/308 at least partially made of carbon
• CPC Class Codes: G01N 27/4071 using sensor elements of laminated structure
• CPC Class Codes: G01N 27/4074 for detection of gases other than oxygen
• CPC Class Codes: G01N 27/4075 Composition or fabrication of the electrodes and coatings thereon, e.g. catalysts
• CPC Class Codes: G01N 27/4166 measuring a particular property of an electrolyte
• CPC Class Codes: G01N 33/4836 using multielectrode arrays

Abstract

An apparatus comprising a plurality of first elongate electrodes (101) separated from a plurality of second transversely oriented elongate electrodes (102) by an electrolyte (103), the plurality of transversely oriented first (101) and second (102) electrodes forming an array of respective electrochemical sensor nodes at the spaced crossings thereof, wherein the first electrodes (101) are configured such that the interaction of an analyte with the first electrode (101) at a sensor node affects an electrical property of the sensor node, and wherein the apparatus comprises respective terminals connected to each electrode (101, 102) for electrical connection to a measurement circuit to enable determination of the presence and/or amount of analyte at a particular sensor node based on a measurement of the electrical property of that sensor node.

Claims

1. An apparatus comprising a plurality of first elongate electrodes separated from and electrically coupled to a plurality of second transversely oriented elongate electrodes by an electrolyte, the plurality of transversely oriented first and second electrodes forming an array of respective electrochemical sensor nodes at the spaced crossings thereof,

wherein the first electrodes are configured such that the interaction of an analyte from a surrounding environment with the first electrode at a sensor node affects an electrical property of the sensor node, and

wherein the apparatus comprises respective terminals connected to each electrode for electrical connection to a measurement circuit to enable determination of the presence and/or amount of analyte at a particular sensor node based on a measurement of the electrical property of that sensor node.

2. The apparatus of claim 1, wherein the first and second electrodes are configured to exhibit a potential difference therebetween, or a change in potential difference therebetween, on interaction of the first electrode with the analyte, the first electrodes configured such that one or more of their electrochemical potential and electrical conductance are dependent upon the amount of analyte present.

3. The apparatus of claim 2, wherein the measurement circuit forms part of the apparatus, the measurement circuit configured to measure the potential difference at the sensor nodes to enable determination of the presence and/or amount of analyte.

4. The apparatus of claim 1, wherein the apparatus is configured such that the first and second electrodes at a sensor node serve as the anode and cathode of an electrochemical sensor, and the second electrode serves as a reference electrode with respect to which the potential of the first electrode is measured.

5. The apparatus of claim 1, wherein the apparatus comprises a further electrode separated from the plurality of second electrodes by an electrolyte, and wherein the apparatus is configured such that the first and further electrode at a sensor node serve as the anode and cathode of an electrochemical sensor, and the second electrode serves as a reference electrode with respect to which the potential of the first electrode is measured.

6. The apparatus of claim 5, wherein the apparatus comprises a feedback loop between the second electrode and the further electrode to hold the second electrode at a reference potential.

7. The apparatus of claim 1, wherein the measurement circuit forms part of the apparatus, the measurement circuit configured to apply a varying potential difference between the first and second electrode at a sensor node and measure current peaks at the first electrode in response to the applied potential difference, and wherein the first electrode is configured such that the position and/or size of the current peaks are dependent upon the presence and/or amount of analyte.

8. The apparatus of claim 1, wherein the plurality of first electrodes are configured such that the electrical property of each sensor node is dependent upon the presence and/or amount of the same analyte.

9. The apparatus of claim 8, wherein the first electrode at each sensor node comprises the same material.

10. The apparatus of claim 1, wherein at least some of the plurality of first electrodes are configured such that the electrical property of the respective sensor nodes is dependent upon the presence and/or amount of different analytes.

11. The apparatus of claim 10, wherein the first electrodes at the respective sensor nodes comprise different materials or the same material with different functionalizations to allow the presence and/or amount of the different respective analytes to be determined.

12. The apparatus of claim 1, wherein the measurement circuit forms part of the apparatus, the measurement circuit comprising a first multiplexer connected to the terminals of the plurality of first electrodes and a second multiplexer connected to the terminals of the plurality of second electrodes, the first and second multiplexers configured to enable the electrical property of a particular sensor node to be selectively determined.

13. The apparatus of claim 1, wherein the apparatus is configured such that the plurality of first electrodes are arranged substantially parallel to one another, the plurality of second electrodes are arranged substantially parallel to one another, and the plurality of first electrodes are arranged substantially perpendicular to the plurality of second electrodes.

14. The apparatus of claim 1, wherein the apparatus comprises microfluidic channels and associated pumps configured to deliver fluid to the sensor nodes for determination of the presence and/or amount of analyte within the fluid.

15. The apparatus of claim 1, wherein one or more of the first electrodes comprise a graphene oxide film.

16. The apparatus of claim 1, wherein the analyte comprises water.

17. The apparatus of claim 1, wherein the apparatus is one or more of an electronic device, a portable electronic device, a portable telecommunications device, a sensor array, and a module for any of the aforementioned devices.

18. A method comprising determining the presence and/or amount of analyte using an apparatus and a measurement circuit, the method comprising:

providing the apparatus comprising a plurality of first elongate electrodes separated from and electrically coupled to a plurality of second transversely oriented elongate electrodes by an electrolyte, the plurality of transversely oriented first and second electrodes forming an array of respective electrochemical sensor nodes at the spaced crossings thereof,

configuring the first electrodes such that the interaction of an analyte from a surrounding environment with the first electrode at a sensor node affects an electrical property of the sensor node,

connecting respective terminals of the apparatus to each electrode for electrical connection to a measurement circuit; and

determining the presence and/or amount of analyte at a particular sensor node based on a measurement of the electrical property of that sensor node.

19. A method of making an apparatus for use in determining the presence and/or amount of analyte, the method comprising:

providing an electrolyte in a spacing between and electrically coupling a plurality of first elongate electrodes and a plurality of second transversely oriented elongate electrodes to form an array of respective electrochemical sensor nodes at spaced crossings of the first and second electrodes, wherein the first electrodes are configured such that the interaction of an analyte from a surrounding environment with the first electrode at a sensor node affects an electrical property of the sensor node; and

providing respective terminals connected to each electrode for electrical connection to a measurement circuit to enable determination of the presence and/or amount of analyte at a particular sensor node based on a measurement of the electrical property of that sensor node.