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Diagnosis of cardiovascular disease

  • US 10,203,339 B2
  • Filed: 05/01/2007
  • Issued: 02/12/2019
  • Est. Priority Date: 05/01/2006
  • Status: Active Grant
First Claim
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1. A method of diagnosing heart failure in a subject who has one or both of a body mass index (BMI) of greater than or equal to 25, and impaired renal function, and treating the subject, the method comprising:

  • (a) one or both of;

    (i) determining the subject'"'"'s BMI, and if the subject'"'"'s BMI is equal to or greater than 25, selecting the subject; and

    (ii) evaluating the subject'"'"'s renal function, and if the subject has impaired renal function, selecting the subject;

    (b) performing an immunoassay to determine a level of brain natriuretic peptide (BNP) and a level of soluble ST2 in a biological sample from the selected subject;

    (c) identifying a selected subject having a BNP level of between 100 pg/mL and 500 pg/mL, and an elevated level of soluble ST2 as compared to a reference level of soluble ST2 as having heart failure; and

    (d) administering a pharmaceutical treatment for heart failure to the identified subject.

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