Computer implemented system and method for assessing a neuropsychiatric condition of a human subject

• US 10,204,707 B2
• Filed: 04/27/2010
• Issued: 02/12/2019
• Est. Priority Date: 04/27/2009
• Status: Active Grant

• Current Assignee: Children's Hospital & Medical Center, Cincinnati Children's Hospital Medical Center (University of Cincinnati)
• Original Assignee: Children's Hospital & Medical Center
• Inventors: Pestian, John, Glauser, Tracy A., Aronow, Bruce
• Primary Examiner(s): Chaki, Kakali
• Assistant Examiner(s): Nilsson, Eric
• Application Number:
  US13/266,272
• Publication Number:
  US 20120041911A1
• Time in Patent Office: 3,213 Days
• CPC Class Codes: G06N 20/00 Machine learning
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

A method for assessing a neuropsychiatric condition (such as, but not limited to, a risk that a subject may attempt to commit suicide or repeat an attempt to commit suicide, a risk that terminally ill patient is not being care-for or treated according to the patient'"'"'s true wishes, a risk that a subject may perform or repeat a criminal act and/or a harmful act, a risk of the subject having a psychiatric illness, and/or a risk of a subject feigning a psychiatric illness) may include a plurality of steps. A step may include receiving biomarker data associated from an analysis of the subject'"'"'s biological sample and a step of receiving thought-marker data obtained pertaining to one or more of the subject'"'"'s recorded thoughts, spoken words, transcribed speech, and writings. A step may include generating a biomarker score associated with the neuropsychiatric condition from the biomarker data. A step may include generating a thought-marker score associated with the neuropsychiatric condition from the thought-marker data. And a step may involve calculating a neuropsychiatric condition score based, at least in part, upon the biomarker score and the thought-marker score. Such method may be operating from one or more memory devices including computer-readable instructions configured to instruct a computerized system to perform the method, and the method may be operating on a computerized system including one or more computer servers (or other available devices) accessible over a computer network such as the Internet or over some other data network.

Claims

1. One or more non-transitory computer readable memory devices including computer-readable instructions configured to instruct a computerized system to perform a method for assessing a suicide attempt risk of a human subject, the method including the steps of:

obtaining a biological sample from the subject;

determining one or more suicide risk associated biological markers by a method comprising one or more of a polymerase chain reaction (PCR), a reverse transcription PCR reaction (RT-PCR), mass spectroscopy (MS), high pressure liquid chromatography (HPLC), LC-MS, DNA sequencing, and an enzyme-linked, bead based, or sandwich immunoassay to provide biomarker data for the subject;

receiving, using one or more processors, the biomarker data;

receiving, using one or more processors, thought-marker data including one or more of the subject'"'"'s recorded thoughts, spoken words, transcribed speech, and writings;

generating, using one or more processors, a numerical biomarker score from the biomarker data, said biomarker score generated by

normalizing, using the one or more processors, the one or more determined suicide risk associated biological markers,

generating a normalized score for each of the markers based on the strength of the marker'"'"'s association with suicide risk and

summing the individual normalized scores for the one or more determined suicide risk associated biological markers;

generating, using one or more processors, a thought-marker score associated with the suicide attempt risk from the thought-marker data by a method comprising the steps of

determining a correlation between (a) the thought marker data of the subject and (b) a corpus of thought data comprising a set of suicide notes language associated with prior completions of suicides,

the correlation determined using a machine learning method implementing a classification algorithm selected from the group consisting of decision trees, classification rules, function models, and instance-based learner methods,

the machine learning method comprising extracting and quantifying relevant content features of the thought marker data and creating a heterogeneous, multidimensional feature space, normalizing the feature values, and

generating the thought-marker score based upon the strength of the correlation,

and

generating a suicide attempt risk score based, at least in part, upon the biomarker score and the thought-marker score, and

generating, using the suicide attempt risk score, a treatment program for the subject.

2. The one or more non-transitory computer readable memory devices of claim 1, wherein the method'"'"'s step of determining one or more suicide risk associated biological markers includes a step of determining a level of a hydroxyindoleacetic acid (5HIAA).

3. The one or more non-transitory computer readable memory devices of claim 1, wherein the method'"'"'s step of determining one or more suicide risk associated biological markers includes a step of determining the presence of the S and L alleles of the 5′

upstream regulatory region of the serotonin transporter gene (5-HTTLPR).

4. The one or more non-transitory computer readable memory devices of claim 1, wherein the method'"'"'s step of determining one or more suicide risk associated biological markers includes a step of determining the presence of one or more single nucleotide polymorphisms taken from a group consisting of:

A218C of the TPH1 gene, A779C of the TPH1 gene, and A59G of the SLC6A3 gene.

5. The one or more non-transitory computer readable memory devices of claim 1, wherein the method'"'"'s step of determining one or more suicide risk associated biological markers includes a step of determining an mRNA level of 5-HT(2A) mRNA.

6. The one or more non-transitory computer readable memory devices of claim 1, wherein the method'"'"'s step of determining one or more suicide risk associated biological markers includes a step of determining a level of one or more cytokines taken from a group consisting of:

IL-6, IL-2, IFN-γ

, IL-4 and TGF-β

1.

7. The one or more non-transitory computer readable memory devices of claim 1, wherein the method'"'"'s step of determining one or more suicide risk associated biological markers includes a step of determining a level of serotonin (5-HT).

8. The one or more non-transitory computer readable memory devices of claim 1, wherein the method further includes:

a step of receiving clinical data of the subject associated with the suicide attempt risk and a step of generating a clinical data score from the clinical data, and

the method'"'"'s step of calculating a suicide attempt risk score is based, at least in further part, upon the clinical data score.

9. The one or more non-transitory computer readable memory devices of claim 8, wherein the clinical data of the subject associated with the suicide risk includes data pertaining to previous suicide attempts by the subject.

10. The one or more non-transitory computer readable memory devices of claim 9, wherein the clinical data of the subject associated with the suicide risk includes further includes one or more of, data pertaining to a level of interpersonal discord, data pertaining to a presence of a mood disorder, data pertaining to a history of substance use, data pertaining to a history of impulsive aggression, data pertaining to a family history of suicidal behavior, data pertaining to access to weapons such as firearms, and data pertaining to recent psychosocial stressors.

11. The one or more non-transitory computer readable memory devices of claim 8, wherein the method'"'"'s step of calculating a suicide risk score includes steps of:

normalizing the biomarker score;

normalizing the thought-marker score;

normalizing the clinical data score; and

calculating a mean of at least the normalized biomarker, thought-marker and clinical data scores.

12. The one or more non-transitory computer readable memory devices of claim 11, wherein the method'"'"'s normalizing steps, normalize between at least one of the following numerical scales:

(a) 0.0 and 1.0, and (b) 0.0 and 10^N, where N is an integer.

13. The one or more non-transitory computer readable memory devices of claim 8, wherein the method'"'"'s step of generating a clinical data score includes a step of calculating a percentage of risks associated with the suicide risk from the subject compared to a predetermined set of risks associated with the suicide risk.

14. The one or more non-transitory computer readable memory devices of claim 1, wherein the method'"'"'s step of generating a biomarker score includes a step of calculating a composite score related to two or more biological markers associated with the suicide risk from the biomarker data.

15. The one or more non-transitory computer readable memory devices of claim 1, wherein the method'"'"'s step of calculating a suicide risk score includes steps of:

normalizing the biomarker score;

normalizing the thought-marker score;

calculating a mean of at least the normalized biomarker and the thought-marker scores.

16. The one or more non-transitory computer readable memory devices of claim 15, wherein the method'"'"'s normalizing steps, normalize between at least one of the following numerical scales:

(a) 0.0 and 1.0, and (b) 0.0 and 10^N, where N is an integer.

17. One or more non-transitory computer readable memory devices including computer-readable instructions configured to instruct a computerized system to perform a method for assessing a suicide attempt risk of a human subject, the method including the steps of:

obtaining a biological sample from the subject;

determining one or more suicide risk associated biological markers based on the obtained biological sample by a method comprising one or more of a polymerase chain reaction (PCR), a reverse transcription PCR reaction (RT-PCR), mass spectroscopy (MS), high pressure liquid chromatography (HPLC), LC-MS, DNA sequencing, and an enzyme-linked, bead based, or sandwich immunoassay;

normalizing, using one or more processors, the one or more determined suicide risk associated biological markers and generating a normalized score for each based on the strength of marker'"'"'s association with suicide risk;

generating, using the one or more processors, a biomarker score based on a sum of individual normalized scores for the one or more determined suicide risk associated biological markers;

receiving, using the one or more processors, one or more thought markers of the subject, the one or more thought markers including one or more of the subject'"'"'s recorded thoughts, spoken words, transcribed speech, and writings;

executing, using the one or more processors, a first query and transmitting the first query to a suicide notes database to obtain a plurality of suicide notes associated with prior completions of suicides, the one or more processors being communicatively coupled to the suicide notes database using one or more communications networks;

comparing, using one or more machine learning methods, the one or more thought markers and the obtained plurality of suicide notes to determine a correlation between (a) the one or more thought markers of the subject and (b) the obtained plurality of suicide notes, the one or more machine learning methods implementing a classification algorithm including at least one of the following;

a decision tree, a classification rule, a function model, an instance-based learner method, and any combination thereof,

the one or more machine learning methods including

extracting and quantifying relevant content features of the one or more thought markers; and

generating, based on extracting and quantifying, a heterogeneous, multidimensional feature space containing a plurality of feature values corresponding to quantified content features;

normalizing the generated feature values; and

generating, using the normalized generated feature values, a thought-marker score based upon a strength of the correlation,

and

generating a suicide attempt risk score based on a combination of the biomarker score and the thought-marker score; and

generating, using the suicide attempt risk score, a treatment program for the subject.