Stable aqueous formulations of adalimumab
DCFirst Claim
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1. A stable aqueous pharmaceutical composition comprising:
- i) adalimumab;
ii) a single buffer;
iii) a surfactant; and
iv) a tonicity modifier,wherein the composition is free of mannitol and has a pH of about 5 to about 6.
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Abstract
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these compositions, methods of administration, and kits containing same.
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11 Claims
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1. A stable aqueous pharmaceutical composition comprising:
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i) adalimumab; ii) a single buffer; iii) a surfactant; and iv) a tonicity modifier, wherein the composition is free of mannitol and has a pH of about 5 to about 6. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification